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Q3J5E8

- MTAP_RHOS4

UniProt

Q3J5E8 - MTAP_RHOS4

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Protein
S-methyl-5'-thioadenosine phosphorylase
Gene
mtnP, RHOS4_04180, RSP_1837
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates By similarity.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111Phosphate By similarity
Sitei166 – 1661Important for substrate specificity By similarity
Binding sitei184 – 1841Substrate; via amide nitrogen By similarity
Binding sitei185 – 1851Phosphate By similarity
Sitei221 – 2211Important for substrate specificity By similarity

GO - Molecular functioni

  1. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. L-methionine salvage from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-431-MONOMER.
UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylase (EC:2.4.2.28)
Alternative name(s):
5'-methylthioadenosine phosphorylase
Short name:
MTA phosphorylase
Short name:
MTAP
Gene namesi
Name:mtnP
Ordered Locus Names:RHOS4_04180
ORF Names:RSP_1837
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290S-methyl-5'-thioadenosine phosphorylaseUniRule annotation
PRO_0000415098Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272943.RSP_1837.

Structurei

3D structure databases

ProteinModelPortaliQ3J5E8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Phosphate binding By similarity
Regioni86 – 872Phosphate binding By similarity
Regioni208 – 2103Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000228986.
KOiK00772.
OMAiISTTACG.
OrthoDBiEOG6KHFXC.
PhylomeDBiQ3J5E8.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3J5E8-1 [UniParc]FASTAAdd to Basket

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MKTMIGVIGG SGVYEIDGLE DAVWTKVETP WGDPSDEILT GRLDGVPMAF    50
LPRHGRGHVH SPTTVPYRAN IDALKRLGVT DLVSVSACGS FREEMAPGDF 100
VIVDQFIDRS FARAKSFFGS GCVAHVSLAH PTCGRLSALC AEAARATGVT 150
VHEGGTYLCM EGPQFSTLAE SLLYKSWGCH VIGMTNMPEA KLAREAEICY 200
ASVAMVTDYD SWHPHHGEVD ITAIIATLGT NADHARGLVA GLPARLGTER 250
DLCPHGCDRA LDHALMTAPA KRDPELLAKL DAVAGRVLKG 290
Length:290
Mass (Da):30,950
Last modified:November 8, 2005 - v1
Checksum:i35B46FAB615584CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA77986.1.
RefSeqiYP_351887.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA77986; ABA77986; RSP_1837.
GeneIDi3719104.
KEGGirsp:RSP_1837.
PATRICi23150648. VBIRhoSph57909_0724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA77986.1 .
RefSeqi YP_351887.1. NC_007493.2.

3D structure databases

ProteinModelPortali Q3J5E8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272943.RSP_1837.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA77986 ; ABA77986 ; RSP_1837 .
GeneIDi 3719104.
KEGGi rsp:RSP_1837.
PATRICi 23150648. VBIRhoSph57909_0724.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000228986.
KOi K00772.
OMAi ISTTACG.
OrthoDBi EOG6KHFXC.
PhylomeDBi Q3J5E8.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .
BioCyci RSPH272943:GJAS-431-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiMTAP_RHOS4
AccessioniPrimary (citable) accession number: Q3J5E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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