Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q3J5D3 (GCH4_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:RHOS4_04330
ORF Names:RSP_1852
OrganismRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Reference proteome] [HAMAP]
Taxonomic identifier272943 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289518

Sites

Site2181May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3J5D3 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: FFD98B7D831BBBE2

FASTA35940,175
        10         20         30         40         50         60 
MNILTPVAER LPSREEAEEA LAVLRRWATH TPASDVAALA PEAPALVYPD LSRAYPRTFT 

        70         80         90        100        110        120 
VDEAYKASLP DLQNGPASLI VGAKAVIQHV GISNFRLPIR YHTRDNGDLQ LETSVTGTVS 

       130        140        150        160        170        180 
LEAEKKGINM SRIMRSFYAH AEQAFSFEVI ERALEDYKRD LESFDARIQM RFSFPVKVPS 

       190        200        210        220        230        240 
LRSGLTGWQY YDIALELVDR GGVRKEIMHL DFVYSSTCPC SLELSEHARR ERGQLATPHS 

       250        260        270        280        290        300 
QRSVARISVE VRQGKCLWFE DLLDLVRSAV PTETQVMVKR EDEQAFAELN AANPIFVEDA 

       310        320        330        340        350 
ARSFCQALQS DPRIGDFRVV ASHQESLHSH DAVSVLTEGP TFAAESLDPR LFSSLYHVG 

« Hide

References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000143 Genomic DNA. Translation: ABA78001.1.
RefSeqYP_351902.1. NC_007493.2.

3D structure databases

ProteinModelPortalQ3J5D3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272943.RSP_1852.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA78001; ABA78001; RSP_1852.
GeneID3719119.
KEGGrsp:RSP_1852.
PATRIC23150680. VBIRhoSph57909_0740.

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000247517.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.
PhylomeDBQ3J5D3.

Enzyme and pathway databases

BioCycRSPH272943:GJAS-446-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_RHOS4
AccessionPrimary (citable) accession number: Q3J5D3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 8, 2005
Last modified: July 9, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways