Q3J5D3 (GCH4_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	RHOS4_04330
ORF Names:	RSP_1852

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Reference proteome] [HAMAP]

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter › Rhodobacter sphaeroides

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_0000289518
Sites
	Site	218	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3J5D3 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: FFD98B7D831BBBE2	FASTA	359	40,175
	10 20 30 40 50 60 MNILTPVAER LPSREEAEEA LAVLRRWATH TPASDVAALA PEAPALVYPD LSRAYPRTFT 70 80 90 100 110 120 VDEAYKASLP DLQNGPASLI VGAKAVIQHV GISNFRLPIR YHTRDNGDLQ LETSVTGTVS 130 140 150 160 170 180 LEAEKKGINM SRIMRSFYAH AEQAFSFEVI ERALEDYKRD LESFDARIQM RFSFPVKVPS 190 200 210 220 230 240 LRSGLTGWQY YDIALELVDR GGVRKEIMHL DFVYSSTCPC SLELSEHARR ERGQLATPHS 250 260 270 280 290 300 QRSVARISVE VRQGKCLWFE DLLDLVRSAV PTETQVMVKR EDEQAFAELN AANPIFVEDA 310 320 330 340 350 ARSFCQALQS DPRIGDFRVV ASHQESLHSH DAVSVLTEGP TFAAESLDPR LFSSLYHVG

References

[1]

"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000143 Genomic DNA. Translation: ABA78001.1.
RefSeq	YP_351902.1. NC_007493.1.
3D structure databases
ProteinModelPortal	Q3J5D3.
ModBase	Search...
Protein-protein interaction databases
STRING	272943.RSP_1852.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3719119.
KEGG	rsp:RSP_1852.
PATRIC	23150680. VBIRhoSph57909_0740.
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000247517.
KO	K09007.
OMA	INMYVDL.
ProtClustDB	PRK13674.
Enzyme and pathway databases
BioCyc	RSPH272943:GJAS-446-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH4_RHOS4

Accession

Primary (citable) accession number: Q3J5D3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program