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Protein

Cytochrome c oxidase subunit 1

Gene

coxI

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541CalciumCombined sources
Metal bindingi57 – 571Calcium; via carbonyl oxygenCombined sources
Metal bindingi59 – 591Calcium; via carbonyl oxygenCombined sources
Metal bindingi61 – 611CalciumCombined sources
Metal bindingi102 – 1021Iron (heme 1 axial ligand); via tele nitrogenCombined sources
Metal bindingi284 – 2841Copper; via pros nitrogenCombined sources
Metal bindingi333 – 3331Copper; via tele nitrogenCombined sources
Metal bindingi334 – 3341Copper; via tele nitrogenCombined sources
Metal bindingi419 – 4191Iron (heme 2 axial ligand); via tele nitrogenCombined sources
Metal bindingi421 – 4211Iron (heme 1 axial ligand); via tele nitrogenCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transport, Respiratory chainUniRule annotation, Transport

Keywords - Ligandi

CalciumCombined sources, CopperUniRule annotationCombined sources, HemeUniRule annotationCombined sources, Iron, Metal-binding

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-472-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:coxIImported
ORF Names:RSP_1877Imported
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)Imported
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 5123HelicalUniRule annotationAdd
BLAST
Transmembranei104 – 12320HelicalUniRule annotationAdd
BLAST
Transmembranei143 – 16220HelicalUniRule annotationAdd
BLAST
Transmembranei189 – 21527HelicalUniRule annotationAdd
BLAST
Transmembranei227 – 25428HelicalUniRule annotationAdd
BLAST
Transmembranei287 – 30620HelicalUniRule annotationAdd
BLAST
Transmembranei313 – 33422HelicalUniRule annotationAdd
BLAST
Transmembranei346 – 36924HelicalUniRule annotationAdd
BLAST
Transmembranei381 – 40020HelicalUniRule annotationAdd
BLAST
Transmembranei420 – 44021HelicalUniRule annotationAdd
BLAST
Transmembranei452 – 47322HelicalUniRule annotationAdd
BLAST
Transmembranei493 – 51927HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 88Combined sources

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_1877.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OM3X-ray2.60A/C17-551[»]
3OMAX-ray2.30A/C17-551[»]
3OMIX-ray2.15A/C17-551[»]
3OMNX-ray2.15A/C17-551[»]
ProteinModelPortaliQ3J5A7.
SMRiQ3J5A7. Positions 14-560.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3J5A7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 558539COX1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiEOG6B35XR.
PhylomeDBiQ3J5A7.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J5A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAAIHGHE HDRRGFFTRW FMSTNHKDIG VLYLFTGGLV GLISVAFTVY
60 70 80 90 100
MRMELMAPGV QFMCAEHLES GLVKGFFQSL WPSAVENCTP NGHLWNVMIT
110 120 130 140 150
GHGILMMFFV VIPALFGGFG NYFMPLHIGA PDMAFPRMNN LSYWLYVAGT
160 170 180 190 200
SLAVASLFAP GGNGQLGSGI GWVLYPPLST SESGYSTDLA IFAVHLSGAS
210 220 230 240 250
SILGAINMIT TFLNMRAPGM TMHKVPLFAW SIFVTAWLIL LALPVLAGAI
260 270 280 290 300
TMLLTDRNFG TTFFQPSGGG DPVLYQHILW FFGHPEVYII VLPAFGIVSH
310 320 330 340 350
VIATFAKKPI FGYLPMVYAM VAIGVLGFVV WAHHMYTAGL SLTQQSYFMM
360 370 380 390 400
ATMVIAVPTG IKIFSWIATM WGGSIELKTP MLWALGFLFL FTVGGVTGIV
410 420 430 440 450
LSQASVDRYY HDTYYVVAHF HYVMSLGAVF GIFAGIYFWI GKMSGRQYPE
460 470 480 490 500
WAGKLHFWMM FVGANLTFFP QHFLGRQGMP RRYIDYPEAF ATWNFVSSLG
510 520 530 540 550
AFLSFASFLF FLGVIFYTLT RGARVTANNY WNEHADTLEW TLTSPPPEHT
560
FEQLPKREDW ERAPAH
Length:566
Mass (Da):63,147
Last modified:November 8, 2005 - v1
Checksum:i65A74DBCC5C550B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA78027.1.
RefSeqiWP_011337048.1. NZ_AKVW01000001.1.
YP_351928.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA78027; ABA78027; RSP_1877.
GeneIDi3719145.
KEGGirsp:RSP_1877.
PATRICi23150734. VBIRhoSph57909_0767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA78027.1.
RefSeqiWP_011337048.1. NZ_AKVW01000001.1.
YP_351928.1. NC_007493.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3OM3X-ray2.60A/C17-551[»]
3OMAX-ray2.30A/C17-551[»]
3OMIX-ray2.15A/C17-551[»]
3OMNX-ray2.15A/C17-551[»]
ProteinModelPortaliQ3J5A7.
SMRiQ3J5A7. Positions 14-560.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_1877.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA78027; ABA78027; RSP_1877.
GeneIDi3719145.
KEGGirsp:RSP_1877.
PATRICi23150734. VBIRhoSph57909_0767.

Phylogenomic databases

eggNOGiENOG4105BZ9. Bacteria.
COG0843. LUCA.
HOGENOMiHOG000085274.
KOiK02274.
OMAiPYHTFEE.
OrthoDBiEOG6B35XR.
PhylomeDBiQ3J5A7.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciRSPH272943:GJAS-472-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ3J5A7.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 2 hits.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158Imported.
  2. "Crystallographic and online spectral evidence for role of conformational change and conserved water in cytochrome oxidase proton pump."
    Liu J., Qin L., Ferguson-Miller S.
    Proc. Natl. Acad. Sci. U.S.A. 108:1284-1289(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 17-551 IN COMPLEX WITH CALCIUM; COPPER AND HEME, DISULFIDE BONDS.

Entry informationi

Entry nameiQ3J5A7_RHOS4
AccessioniPrimary (citable) accession number: Q3J5A7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.