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Protein

Cytochrome c oxidase subunit 1

Gene

coxI

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54CalciumCombined sources1
Metal bindingi57Calcium; via carbonyl oxygenCombined sources1
Metal bindingi59Calcium; via carbonyl oxygenCombined sources1
Metal bindingi61CalciumCombined sources1
Metal bindingi102Iron (heme 1 axial ligand); via tele nitrogenCombined sources1
Metal bindingi284Copper; via pros nitrogenCombined sources1
Metal bindingi333Copper; via tele nitrogenCombined sources1
Metal bindingi334Copper; via tele nitrogenCombined sources1
Metal bindingi419Iron (heme 2 axial ligand); via tele nitrogenCombined sources1
Metal bindingi421Iron (heme 1 axial ligand); via tele nitrogenCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCalciumCombined sources, CopperUniRule annotationCombined sources, HemeUniRule annotationCombined sources, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:coxIImported
ORF Names:RSP_1877Imported
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)Imported
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 51HelicalUniRule annotationAdd BLAST23
Transmembranei104 – 123HelicalUniRule annotationAdd BLAST20
Transmembranei143 – 162HelicalUniRule annotationAdd BLAST20
Transmembranei189 – 215HelicalUniRule annotationAdd BLAST27
Transmembranei227 – 254HelicalUniRule annotationAdd BLAST28
Transmembranei287 – 306HelicalUniRule annotationAdd BLAST20
Transmembranei313 – 334HelicalUniRule annotationAdd BLAST22
Transmembranei346 – 369HelicalUniRule annotationAdd BLAST24
Transmembranei381 – 400HelicalUniRule annotationAdd BLAST20
Transmembranei420 – 440HelicalUniRule annotationAdd BLAST21
Transmembranei452 – 473HelicalUniRule annotationAdd BLAST22
Transmembranei493 – 519HelicalUniRule annotationAdd BLAST27

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 88Combined sources

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_1877

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OM3X-ray2.60A/C17-551[»]
3OMAX-ray2.30A/C17-551[»]
3OMIX-ray2.15A/C17-551[»]
3OMNX-ray2.15A/C17-551[»]
ProteinModelPortaliQ3J5A7
SMRiQ3J5A7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ3J5A7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 558COX1InterPro annotationAdd BLAST539

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
HOGENOMiHOG000085274
KOiK02274
OMAiYLMILPI
OrthoDBiPOG091H042R
PhylomeDBiQ3J5A7

Family and domain databases

CDDicd01663 Cyt_c_Oxidase_I, 1 hit
Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR033944 Cyt_c_oxase_su1_dom
IPR014241 Cyt_c_oxidase_su1_bac
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q3J5A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAAIHGHE HDRRGFFTRW FMSTNHKDIG VLYLFTGGLV GLISVAFTVY
60 70 80 90 100
MRMELMAPGV QFMCAEHLES GLVKGFFQSL WPSAVENCTP NGHLWNVMIT
110 120 130 140 150
GHGILMMFFV VIPALFGGFG NYFMPLHIGA PDMAFPRMNN LSYWLYVAGT
160 170 180 190 200
SLAVASLFAP GGNGQLGSGI GWVLYPPLST SESGYSTDLA IFAVHLSGAS
210 220 230 240 250
SILGAINMIT TFLNMRAPGM TMHKVPLFAW SIFVTAWLIL LALPVLAGAI
260 270 280 290 300
TMLLTDRNFG TTFFQPSGGG DPVLYQHILW FFGHPEVYII VLPAFGIVSH
310 320 330 340 350
VIATFAKKPI FGYLPMVYAM VAIGVLGFVV WAHHMYTAGL SLTQQSYFMM
360 370 380 390 400
ATMVIAVPTG IKIFSWIATM WGGSIELKTP MLWALGFLFL FTVGGVTGIV
410 420 430 440 450
LSQASVDRYY HDTYYVVAHF HYVMSLGAVF GIFAGIYFWI GKMSGRQYPE
460 470 480 490 500
WAGKLHFWMM FVGANLTFFP QHFLGRQGMP RRYIDYPEAF ATWNFVSSLG
510 520 530 540 550
AFLSFASFLF FLGVIFYTLT RGARVTANNY WNEHADTLEW TLTSPPPEHT
560
FEQLPKREDW ERAPAH
Length:566
Mass (Da):63,147
Last modified:November 8, 2005 - v1
Checksum:i65A74DBCC5C550B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA Translation: ABA78027.1
RefSeqiWP_011337048.1, NZ_AKVW01000001.1
YP_351928.1, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA78027; ABA78027; RSP_1877
GeneIDi3719145
KEGGirsp:RSP_1877
PATRICifig|272943.9.peg.767

Similar proteinsi

Entry informationi

Entry nameiQ3J5A7_RHOS4
AccessioniPrimary (citable) accession number: Q3J5A7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

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