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Protein

Putative histidinol dehydrogenase 2

Gene

hisD2

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Proton acceptorUniRule annotation
Active sitei335 – 3351Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-762-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histidinol dehydrogenase 2 (EC:1.1.1.23UniRule annotation)
Short name:
HDH 2UniRule annotation
Gene namesi
Name:hisD2UniRule annotation
Ordered Locus Names:RHOS4_07400
ORF Names:RSP_2155
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Putative histidinol dehydrogenase 2PRO_0000229864Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_2155.

Structurei

3D structure databases

ProteinModelPortaliQ3J4H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWVVAAKR.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ3J4H6.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J4H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQVNFQVLA ELDAAGRAAL LRRSETDLSM FLEKVGPILE AVRTEGDAAL
60 70 80 90 100
VRFGRELDRA EGLTREGLKV TEAEFDEAFG LVEPEIVAAI RFAIGNIRTF
110 120 130 140 150
HEEQAPEPMW LKELRPGAFA GDRFTPIRSV ALYVPRGKGS FPSVTMMTSV
160 170 180 190 200
PAVVAKVPQI AIFTPPAPDG RVDAATLVAA RLAGVETVYK VGGAQAVAAA
210 220 230 240 250
AYGTETVTPA LKIVGPGSPW VVAAKRLLAG VIDPGLPAGP SESIILADET
260 270 280 290 300
VHGGLAALDL LIEAEHGPDS SAWLVTHSRQ VAEEALAALP GHWSAMTPQR
310 320 330 340 350
VDFSQAVLCG RAGGIVLTGS AEESHAFVND YAPEHLQILS EKPFEHLGRI
360 370 380 390 400
TEAAEVLMGP HTPITIANFC LGPNAVLPTS RGARTWGPLS VHDFLRRSSV
410 420 430 440
GYVTAPAYPE LAEVAKRLAE YEGFSSHANA VGPMRDAYLK R
Length:441
Mass (Da):46,882
Last modified:November 8, 2005 - v1
Checksum:iB1481F195AAEA18E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA78308.1.
RefSeqiWP_011337274.1. NZ_AKVW01000001.1.
YP_352209.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA78308; ABA78308; RSP_2155.
GeneIDi3719625.
KEGGirsp:RSP_2155.
PATRICi23151312. VBIRhoSph57909_1051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA78308.1.
RefSeqiWP_011337274.1. NZ_AKVW01000001.1.
YP_352209.1. NC_007493.2.

3D structure databases

ProteinModelPortaliQ3J4H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_2155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA78308; ABA78308; RSP_2155.
GeneIDi3719625.
KEGGirsp:RSP_2155.
PATRICi23151312. VBIRhoSph57909_1051.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiWVVAAKR.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ3J4H6.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciRSPH272943:GJAS-762-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiHISX2_RHOS4
AccessioniPrimary (citable) accession number: Q3J4H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: April 1, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could lack activity as the potential substrate and zinc-binding sites are missing.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.