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Q3J4H6

- HISX2_RHOS4

UniProt

Q3J4H6 - HISX2_RHOS4

Protein

Putative histidinol dehydrogenase 2

Gene

hisD2

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei334 – 3341Proton acceptorUniRule annotation
    Active sitei335 – 3351Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciRSPH272943:GJAS-762-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative histidinol dehydrogenase 2 (EC:1.1.1.23UniRule annotation)
    Short name:
    HDH 2UniRule annotation
    Gene namesi
    Name:hisD2UniRule annotation
    Ordered Locus Names:RHOS4_07400
    ORF Names:RSP_2155
    OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
    Taxonomic identifieri272943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002703: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Putative histidinol dehydrogenase 2PRO_0000229864Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272943.RSP_2155.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3J4H6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYEGFSSH.
    OrthoDBiEOG6CVVCR.
    PhylomeDBiQ3J4H6.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3J4H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQVNFQVLA ELDAAGRAAL LRRSETDLSM FLEKVGPILE AVRTEGDAAL    50
    VRFGRELDRA EGLTREGLKV TEAEFDEAFG LVEPEIVAAI RFAIGNIRTF 100
    HEEQAPEPMW LKELRPGAFA GDRFTPIRSV ALYVPRGKGS FPSVTMMTSV 150
    PAVVAKVPQI AIFTPPAPDG RVDAATLVAA RLAGVETVYK VGGAQAVAAA 200
    AYGTETVTPA LKIVGPGSPW VVAAKRLLAG VIDPGLPAGP SESIILADET 250
    VHGGLAALDL LIEAEHGPDS SAWLVTHSRQ VAEEALAALP GHWSAMTPQR 300
    VDFSQAVLCG RAGGIVLTGS AEESHAFVND YAPEHLQILS EKPFEHLGRI 350
    TEAAEVLMGP HTPITIANFC LGPNAVLPTS RGARTWGPLS VHDFLRRSSV 400
    GYVTAPAYPE LAEVAKRLAE YEGFSSHANA VGPMRDAYLK R 441
    Length:441
    Mass (Da):46,882
    Last modified:November 8, 2005 - v1
    Checksum:iB1481F195AAEA18E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA78308.1.
    RefSeqiWP_011337274.1. NZ_AKVW01000001.1.
    YP_352209.1. NC_007493.2.

    Genome annotation databases

    EnsemblBacteriaiABA78308; ABA78308; RSP_2155.
    GeneIDi3719625.
    KEGGirsp:RSP_2155.
    PATRICi23151312. VBIRhoSph57909_1051.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA78308.1 .
    RefSeqi WP_011337274.1. NZ_AKVW01000001.1.
    YP_352209.1. NC_007493.2.

    3D structure databases

    ProteinModelPortali Q3J4H6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272943.RSP_2155.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA78308 ; ABA78308 ; RSP_2155 .
    GeneIDi 3719625.
    KEGGi rsp:RSP_2155.
    PATRICi 23151312. VBIRhoSph57909_1051.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YEGFSSH.
    OrthoDBi EOG6CVVCR.
    PhylomeDBi Q3J4H6.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci RSPH272943:GJAS-762-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

    Entry informationi

    Entry nameiHISX2_RHOS4
    AccessioniPrimary (citable) accession number: Q3J4H6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Could lack activity as the potential substrate and zinc-binding sites are missing.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3