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Q3J4H6

- HISX2_RHOS4

UniProt

Q3J4H6 - HISX2_RHOS4

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Protein
Putative histidinol dehydrogenase 2
Gene
hisD2, RHOS4_07400, RSP_2155
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei334 – 3341Proton acceptor By similarity
Active sitei335 – 3351Proton acceptor By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-762-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histidinol dehydrogenase 2 (EC:1.1.1.23)
Short name:
HDH 2
Gene namesi
Name:hisD2
Ordered Locus Names:RHOS4_07400
ORF Names:RSP_2155
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Putative histidinol dehydrogenase 2UniRule annotation
PRO_0000229864Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_2155.

Structurei

3D structure databases

ProteinModelPortaliQ3J4H6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYEGFSSH.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ3J4H6.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J4H6-1 [UniParc]FASTAAdd to Basket

« Hide

MVQVNFQVLA ELDAAGRAAL LRRSETDLSM FLEKVGPILE AVRTEGDAAL    50
VRFGRELDRA EGLTREGLKV TEAEFDEAFG LVEPEIVAAI RFAIGNIRTF 100
HEEQAPEPMW LKELRPGAFA GDRFTPIRSV ALYVPRGKGS FPSVTMMTSV 150
PAVVAKVPQI AIFTPPAPDG RVDAATLVAA RLAGVETVYK VGGAQAVAAA 200
AYGTETVTPA LKIVGPGSPW VVAAKRLLAG VIDPGLPAGP SESIILADET 250
VHGGLAALDL LIEAEHGPDS SAWLVTHSRQ VAEEALAALP GHWSAMTPQR 300
VDFSQAVLCG RAGGIVLTGS AEESHAFVND YAPEHLQILS EKPFEHLGRI 350
TEAAEVLMGP HTPITIANFC LGPNAVLPTS RGARTWGPLS VHDFLRRSSV 400
GYVTAPAYPE LAEVAKRLAE YEGFSSHANA VGPMRDAYLK R 441
Length:441
Mass (Da):46,882
Last modified:November 8, 2005 - v1
Checksum:iB1481F195AAEA18E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA78308.1.
RefSeqiWP_011337274.1. NZ_AKVW01000001.1.
YP_352209.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA78308; ABA78308; RSP_2155.
GeneIDi3719625.
KEGGirsp:RSP_2155.
PATRICi23151312. VBIRhoSph57909_1051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA78308.1 .
RefSeqi WP_011337274.1. NZ_AKVW01000001.1.
YP_352209.1. NC_007493.2.

3D structure databases

ProteinModelPortali Q3J4H6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272943.RSP_2155.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA78308 ; ABA78308 ; RSP_2155 .
GeneIDi 3719625.
KEGGi rsp:RSP_2155.
PATRICi 23151312. VBIRhoSph57909_1051.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YEGFSSH.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q3J4H6.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci RSPH272943:GJAS-762-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiHISX2_RHOS4
AccessioniPrimary (citable) accession number: Q3J4H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Could lack activity as the potential substrate and zinc-binding sites are missing.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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