Reviewed, UniProtKB/Swiss-Prot Q3J4H6 (HISX2_RHOS4)

Names and origin

Protein names

Recommended name:
    Putative histidinol dehydrogenase 2
      Short name=HDH 2
    EC=1.1.1.23

Gene names

Name:	hisD2
Ordered Locus Names:	RHOS4_07400
ORF Names:	RSP_2155

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Complete proteome] [HAMAP]

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.
Catalytic activity	L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
Sequence similarities	Belongs to the histidinol dehydrogenase family.
Caution	Could lack activity as the potential substrate and zinc-binding sites are missing.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro histidinol dehydrogenase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Putative histidinol dehydrogenase 2		PRO_0000229864
Sites
	Active site	334	1	Proton acceptor By similarity
	Active site	335	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3J4H6-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: B1481F195AAEA18E	FASTA	441	46,882
	10 20 30 40 50 60 MVQVNFQVLA ELDAAGRAAL LRRSETDLSM FLEKVGPILE AVRTEGDAAL VRFGRELDRA 70 80 90 100 110 120 EGLTREGLKV TEAEFDEAFG LVEPEIVAAI RFAIGNIRTF HEEQAPEPMW LKELRPGAFA 130 140 150 160 170 180 GDRFTPIRSV ALYVPRGKGS FPSVTMMTSV PAVVAKVPQI AIFTPPAPDG RVDAATLVAA 190 200 210 220 230 240 RLAGVETVYK VGGAQAVAAA AYGTETVTPA LKIVGPGSPW VVAAKRLLAG VIDPGLPAGP 250 260 270 280 290 300 SESIILADET VHGGLAALDL LIEAEHGPDS SAWLVTHSRQ VAEEALAALP GHWSAMTPQR 310 320 330 340 350 360 VDFSQAVLCG RAGGIVLTGS AEESHAFVND YAPEHLQILS EKPFEHLGRI TEAAEVLMGP 370 380 390 400 410 420 HTPITIANFC LGPNAVLPTS RGARTWGPLS VHDFLRRSSV GYVTAPAYPE LAEVAKRLAE 430 440 YEGFSSHANA VGPMRDAYLK R

References

[1]

"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000143 Genomic DNA. Translation: ABA78308.1.
RefSeq	YP_352209.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3719625.
GenomeReviews	Gene locus RHOS4_07400 in contig CP000143_GR.
KEGG	rsp:RSP_2155.
NMPDR	fig|272943.3.peg.1346.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3J4H6.
Enzyme and pathway databases
BioCyc	RSPH272943:RSP_2155-MON.
Family and domain databases
HAMAP	MF_01024. Divergent sequence. [Tree]
InterPro	IPR001692. Histidinol_DHase. IPR012131. Hstdl_DHase_prok. [Graphical view]
PANTHER	PTHR21256:SF2. Hstdl_DH_prok. 1 hit.
Pfam	PF00815. Histidinol_dh. 1 hit. [Graphical view]
PRINTS	PR00083. HOLDHDRGNASE.
ProDom	PD002680. Histidinol_dh. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00069. hisD. 1 hit.
PROSITE	PS00611. HISOL_DEHYDROGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HISX2_RHOS4

Accession

Primary (citable) accession number: Q3J4H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 8, 2005
Last modified:	November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)