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Q3J4E9 (BETB_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase

Short name=BADH
EC=1.2.1.8
Gene names
Name:betB
Ordered Locus Names:RHOS4_07670
ORF Names:RSP_2183
OrganismRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Reference proteome] [HAMAP]
Taxonomic identifier272943 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity. HAMAP-Rule MF_00804

Catalytic activity

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00804

Cofactor

Binds 2 potassium ions per subunit By similarity. HAMAP-Rule MF_00804

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP-Rule MF_00804

Subunit structure

Dimer of dimers By similarity. HAMAP-Rule MF_00804

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483NAD/NADP-dependent betaine aldehyde dehydrogenase HAMAP-Rule MF_00804
PRO_1000047055

Regions

Nucleotide binding149 – 1524NAD/NADP By similarity
Nucleotide binding175 – 1784NAD/NADP By similarity
Nucleotide binding227 – 2326NAD/NADP By similarity

Sites

Active site1611Charge relay system By similarity
Active site2491Proton acceptor By similarity
Active site4571Charge relay system By similarity
Metal binding271Potassium 1; via carbonyl oxygen By similarity
Metal binding931Potassium 1 By similarity
Metal binding1791Potassium 1; via carbonyl oxygen By similarity
Metal binding2431Potassium 2; via carbonyl oxygen By similarity
Metal binding4501Potassium 2; via carbonyl oxygen By similarity
Metal binding4531Potassium 2; via carbonyl oxygen By similarity
Binding site2081NAD/NADP; via amide nitrogen By similarity
Binding site2831NAD/NADP By similarity
Binding site3801NAD/NADP By similarity

Amino acid modifications

Modified residue2831Cysteine sulfenic acid (-SOH) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3J4E9 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 9BFC75AA2D687748

FASTA48350,804
        10         20         30         40         50         60 
MRAQPAASHF VDGRPLEDET GAPIPVIYPA TGEEIARLHE ATPAVIEAAL ASGARAQAAW 

        70         80         90        100        110        120 
AAMRPVERAR ILRRASDLIR AHNEELSLLE TLDTGKPLQE TLVADWASGA DALEFFAGLA 

       130        140        150        160        170        180 
PVVTGETVPL GQDFVYTIRE PLGLCVGIGA WNYPSQIACW KAAPALALGN AMVFKPSEVT 

       190        200        210        220        230        240 
PLGALKLAEI LIEAGLPPGL FNVVQGRGAV GASLVTDSRV AKVSLTGSVP TGRRVYAAAA 

       250        260        270        280        290        300 
EGVRHVTMEL GGKSPLIVFD DADLESAIGA AMLGNFYSAG QICSNGTRVF VQKGIKEAFL 

       310        320        330        340        350        360 
ARLAERADAI RMGDPLDPEV QMGPLVSQAQ LEKVLAYIEK ARAEGGRLVC GGEASVSPGC 

       370        380        390        400        410        420 
YVQPTVFADV TDAMTLAREE VFGPVMAVLD FETEEEAIAR ANATDFGLAA GVFTADLTRA 

       430        440        450        460        470        480 
HRVVAQLQAG TCWINAYNLT PVEAPFGGVK LSGVGRENGR AAVQHYTQVK SVYVGMGPVD 


APY 

« Hide

References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000143 Genomic DNA. Translation: ABA78335.1.
RefSeqYP_352236.1. NC_007493.2.

3D structure databases

ProteinModelPortalQ3J4E9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272943.RSP_2183.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABA78335; ABA78335; RSP_2183.
GeneID3719653.
KEGGrsp:RSP_2183.
PATRIC23151370. VBIRhoSph57909_1079.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00130.
OMAAHRTIHR.
OrthoDBEOG6BS8QW.
ProtClustDBPRK13252.

Enzyme and pathway databases

BioCycRSPH272943:GJAS-790-MONOMER.
UniPathwayUPA00529; UER00386.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_00804. BADH.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR01804. BADH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETB_RHOS4
AccessionPrimary (citable) accession number: Q3J4E9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways