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Q3J4E9

- BETB_RHOS4

UniProt

Q3J4E9 - BETB_RHOS4

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi27 – 271Potassium 1; via carbonyl oxygenUniRule annotation
    Metal bindingi93 – 931Potassium 1UniRule annotation
    Active sitei161 – 1611Charge relay systemUniRule annotation
    Metal bindingi179 – 1791Potassium 1; via carbonyl oxygenUniRule annotation
    Binding sitei208 – 2081NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi243 – 2431Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei249 – 2491Proton acceptorUniRule annotation
    Binding sitei283 – 2831NAD/NADPUniRule annotation
    Binding sitei380 – 3801NAD/NADPUniRule annotation
    Metal bindingi450 – 4501Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi453 – 4531Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei457 – 4571Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi149 – 1524NAD/NADPUniRule annotation
    Nucleotide bindingi175 – 1784NAD/NADPUniRule annotation
    Nucleotide bindingi227 – 2326NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciRSPH272943:GJAS-790-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:RHOS4_07670
    ORF Names:RSP_2183
    OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
    Taxonomic identifieri272943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002703: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000047055Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei283 – 2831Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi272943.RSP_2183.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3J4E9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiCEHQLVA.
    OrthoDBiEOG6BS8QW.
    PhylomeDBiQ3J4E9.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3J4E9-1 [UniParc]FASTAAdd to Basket

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    MRAQPAASHF VDGRPLEDET GAPIPVIYPA TGEEIARLHE ATPAVIEAAL    50
    ASGARAQAAW AAMRPVERAR ILRRASDLIR AHNEELSLLE TLDTGKPLQE 100
    TLVADWASGA DALEFFAGLA PVVTGETVPL GQDFVYTIRE PLGLCVGIGA 150
    WNYPSQIACW KAAPALALGN AMVFKPSEVT PLGALKLAEI LIEAGLPPGL 200
    FNVVQGRGAV GASLVTDSRV AKVSLTGSVP TGRRVYAAAA EGVRHVTMEL 250
    GGKSPLIVFD DADLESAIGA AMLGNFYSAG QICSNGTRVF VQKGIKEAFL 300
    ARLAERADAI RMGDPLDPEV QMGPLVSQAQ LEKVLAYIEK ARAEGGRLVC 350
    GGEASVSPGC YVQPTVFADV TDAMTLAREE VFGPVMAVLD FETEEEAIAR 400
    ANATDFGLAA GVFTADLTRA HRVVAQLQAG TCWINAYNLT PVEAPFGGVK 450
    LSGVGRENGR AAVQHYTQVK SVYVGMGPVD APY 483
    Length:483
    Mass (Da):50,804
    Last modified:November 8, 2005 - v1
    Checksum:i9BFC75AA2D687748
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA78335.1.
    RefSeqiWP_011337293.1. NZ_AKVW01000001.1.
    YP_352236.1. NC_007493.2.

    Genome annotation databases

    EnsemblBacteriaiABA78335; ABA78335; RSP_2183.
    GeneIDi3719653.
    KEGGirsp:RSP_2183.
    PATRICi23151370. VBIRhoSph57909_1079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA78335.1 .
    RefSeqi WP_011337293.1. NZ_AKVW01000001.1.
    YP_352236.1. NC_007493.2.

    3D structure databases

    ProteinModelPortali Q3J4E9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272943.RSP_2183.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA78335 ; ABA78335 ; RSP_2183 .
    GeneIDi 3719653.
    KEGGi rsp:RSP_2183.
    PATRICi 23151370. VBIRhoSph57909_1079.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi CEHQLVA.
    OrthoDBi EOG6BS8QW.
    PhylomeDBi Q3J4E9.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci RSPH272943:GJAS-790-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

    Entry informationi

    Entry nameiBETB_RHOS4
    AccessioniPrimary (citable) accession number: Q3J4E9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3