Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei67 – 671UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-1163-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:RHOS4_11350
ORF Names:RSP_2544
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Protein-L-isoaspartate O-methyltransferasePRO_0000351920Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_2544.

Structurei

3D structure databases

ProteinModelPortaliQ3J3D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiCFARYIH.
OrthoDBiEOG644ZP2.
PhylomeDBiQ3J3D1.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J3D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEADGEDP AERKMRFLFA VRSRGVTDAR VLAAMERIDR GAFVRGIFAD
60 70 80 90 100
RAYEDMPLPI ACGQTISQPS VVGLMSQALA VNPRDKVLEV GTGSGYQAAV
110 120 130 140 150
LSQLARRVYT VDRHRRLVRE ATEVFHRLSL TNITALIADG SFGLPEQAPF
160 170 180 190 200
DRILVTAAAE DPPGPLLAQL KIGGIMVVPV GQTDAVQNLI KVTRLEQGYD
210
YEELRPVRFV PLVEGIGSD
Length:219
Mass (Da):23,874
Last modified:November 8, 2005 - v1
Checksum:iD0AA21ED7084DD49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA78703.1.
RefSeqiWP_002719695.1. NZ_AKVW01000001.1.
YP_352604.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA78703; ABA78703; RSP_2544.
GeneIDi3720179.
KEGGirsp:RSP_2544.
PATRICi23152145. VBIRhoSph57909_1464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA78703.1.
RefSeqiWP_002719695.1. NZ_AKVW01000001.1.
YP_352604.1. NC_007493.2.

3D structure databases

ProteinModelPortaliQ3J3D1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_2544.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA78703; ABA78703; RSP_2544.
GeneIDi3720179.
KEGGirsp:RSP_2544.
PATRICi23152145. VBIRhoSph57909_1464.

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiCFARYIH.
OrthoDBiEOG644ZP2.
PhylomeDBiQ3J3D1.

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-1163-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiPS01279. PCMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiPIMT_RHOS4
AccessioniPrimary (citable) accession number: Q3J3D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: November 8, 2005
Last modified: May 11, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.