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Protein

S-adenosylmethionine:tRNA ribosyltransferase-isomerase

Gene

queA

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 7-aminomethyl-7-carbaguanosine(34) in tRNA = L-methionine + adenine + epoxyqueuosine(34) in tRNA.UniRule annotation

Pathwayi: tRNA-queuosine biosynthesis

This protein is involved in the pathway tRNA-queuosine biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tRNA-queuosine biosynthesis and in tRNA modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processQueuosine biosynthesis
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00392

Names & Taxonomyi

Protein namesi
Recommended name:
S-adenosylmethionine:tRNA ribosyltransferase-isomeraseUniRule annotation (EC:2.4.99.17UniRule annotation)
Alternative name(s):
Queuosine biosynthesis protein QueAUniRule annotation
Gene namesi
Name:queAUniRule annotation
Ordered Locus Names:RHOS4_15640
ORF Names:RSP_2971
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002313641 – 346S-adenosylmethionine:tRNA ribosyltransferase-isomeraseAdd BLAST346

Proteomic databases

PRIDEiQ3J252

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272943.RSP_2971

Structurei

3D structure databases

ProteinModelPortaliQ3J252
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2N Bacteria
COG0809 LUCA
HOGENOMiHOG000004401
KOiK07568
OMAiYSYGDGM
OrthoDBiPOG091H00ZG
PhylomeDBiQ3J252

Family and domain databases

HAMAPiMF_00113 QueA, 1 hit
InterProiView protein in InterPro
IPR003699 QueA
IPR036100 QueA_sf
PANTHERiPTHR30307 PTHR30307, 1 hit
PfamiView protein in Pfam
PF02547 Queuosine_synth, 1 hit
SUPFAMiSSF111337 SSF111337, 1 hit
TIGRFAMsiTIGR00113 queA, 1 hit

Sequencei

Sequence statusi: Complete.

Q3J252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLSDFDFDL PERLIATRPA RPRTAARLLL AEGDRIEDRH VRDLVGIFRP
60 70 80 90 100
GDRLVLNNTR VIPARLTGTR TRGEAEARVE VTLMEPAAAG GWRAMAKPLR
110 120 130 140 150
KLKPGETIRF SDALSAEVAE KGETDLRLVF DRAGAAFDAA LAEAGAMPLP
160 170 180 190 200
PYIAARRAPD TQDDEDYQTV FARHAGAVAA PTASLHFDRP LLEALAARGV
210 220 230 240 250
GFTEVTLHVG AGTFLPVKVE DVTTHRMHAE WGEVTETAAA EIAATKAAGG
260 270 280 290 300
RVIPVGTTAL RLIESAAASG AIRPWRGETD IFIYPGYRFR VTDALMTNFH
310 320 330 340
LPKSTLLMLV SALMGQERIR AIYDHAVRHD YRFFSYGDAS LLIPGG
Length:346
Mass (Da):37,704
Last modified:November 8, 2005 - v1
Checksum:i3A09EECD9AA4D11A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA Translation: ABA79132.1
RefSeqiWP_011337883.1, NZ_AKVW01000001.1
YP_353033.1, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA79132; ABA79132; RSP_2971
GeneIDi3720385
KEGGirsp:RSP_2971
PATRICifig|272943.9.peg.1911

Similar proteinsi

Entry informationi

Entry nameiQUEA_RHOS4
AccessioniPrimary (citable) accession number: Q3J252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health