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Q3J0X4

- SYT_RHOS4

UniProt

Q3J0X4 - SYT_RHOS4

Protein

Threonine--tRNA ligase

Gene

thrS

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi344 – 3441Zinc; catalyticUniRule annotation
    Metal bindingi395 – 3951Zinc; catalyticUniRule annotation
    Metal bindingi521 – 5211Zinc; catalyticUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. threonine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. threonyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciRSPH272943:GJAS-2045-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Threonine--tRNA ligaseUniRule annotation (EC:6.1.1.3UniRule annotation)
    Alternative name(s):
    Threonyl-tRNA synthetaseUniRule annotation
    Short name:
    ThrRSUniRule annotation
    Gene namesi
    Name:thrSUniRule annotation
    Ordered Locus Names:RHOS4_19920
    ORF Names:RSP_0385
    OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
    Taxonomic identifieri272943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002703: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 646646Threonine--tRNA ligasePRO_1000020490Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272943.RSP_0385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3J0X4.
    SMRiQ3J0X4. Positions 246-641.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni247 – 544298CatalyticAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0441.
    HOGENOMiHOG000003880.
    KOiK01868.
    OMAiMNCPSHH.
    OrthoDBiEOG61KBFJ.
    PhylomeDBiQ3J0X4.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_00184. Thr_tRNA_synth.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view]
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view]
    PRINTSiPR01047. TRNASYNTHTHR.
    SMARTiSM00863. tRNA_SAD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsiTIGR00418. thrS. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3J0X4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQISLTFPD GKAREFPAGI TPAEVAASIS TSLGKKAISA SVDGRHYDLQ    50
    WPIETDAKIA IHTMADEAQA LELIRHDLAH IMARAVQELW PDVKVTIGPV 100
    VANGWYYDFD REETFTPEDL GAIEKRMKEI INAREAVKTE LWERARAIAY 150
    YEERGEPFKV ELVQAIPEDQ SIRMYWHGGW QDLCRGPHLQ HTGQVPADAF 200
    KLMSVAGAYW RGDSANKQLQ RIYGVAFKTR DELKAYLHML EEAAKRDHRK 250
    LGREMELFHL QEEAPGMVFW HPNGWQIYRT LEDYMRGRLR QAGYKEIRTP 300
    QVVDRKLWEA SGHWEAYKEN MFIVEVEEEH AKEKRINALK PMNCPCHVQV 350
    YNQGLKSYRD LPLRLAEFGS CHRYESSGSM HGLMRVRGFV QDDAHIFCTE 400
    DQIESECAAF IELLSSVYKD LGFDSFEIKL STRPEVRIGS DEAWDKVETA 450
    LENAIRKVGA AYEIDPGEGA FYGPKLDFKL TDAIGRKWQC GTFQVDPNLP 500
    TRLGAEYIGE DGAKHRPYML HRAILGSFER FIGILIENYA GKLPFWLAPR 550
    QVVVASIVSD ADPYVAEVVA ALRARGVRAE ADTRNEKINY KVREHSVGKV 600
    PVILAIGMQE VEARSVSVRR LGETRTESMG LDQVVDQLAA DARIPG 646
    Length:646
    Mass (Da):73,352
    Last modified:November 8, 2005 - v1
    Checksum:iBEC094BCB08C81DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA79560.1.
    RefSeqiWP_011338194.1. NZ_AKVW01000001.1.
    YP_353461.1. NC_007493.2.

    Genome annotation databases

    EnsemblBacteriaiABA79560; ABA79560; RSP_0385.
    GeneIDi3718893.
    KEGGirsp:RSP_0385.
    PATRICi23153912. VBIRhoSph57909_2331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA79560.1 .
    RefSeqi WP_011338194.1. NZ_AKVW01000001.1.
    YP_353461.1. NC_007493.2.

    3D structure databases

    ProteinModelPortali Q3J0X4.
    SMRi Q3J0X4. Positions 246-641.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272943.RSP_0385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA79560 ; ABA79560 ; RSP_0385 .
    GeneIDi 3718893.
    KEGGi rsp:RSP_0385.
    PATRICi 23153912. VBIRhoSph57909_2331.

    Phylogenomic databases

    eggNOGi COG0441.
    HOGENOMi HOG000003880.
    KOi K01868.
    OMAi MNCPSHH.
    OrthoDBi EOG61KBFJ.
    PhylomeDBi Q3J0X4.

    Enzyme and pathway databases

    BioCyci RSPH272943:GJAS-2045-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_00184. Thr_tRNA_synth.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR012675. Beta-grasp_dom.
    IPR004095. TGS.
    IPR012676. TGS-like.
    IPR002320. Thr-tRNA-ligase_IIa.
    IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
    IPR012947. tRNA_SAD.
    [Graphical view ]
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF02824. TGS. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    PF07973. tRNA_SAD. 1 hit.
    [Graphical view ]
    PRINTSi PR01047. TRNASYNTHTHR.
    SMARTi SM00863. tRNA_SAD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF55186. SSF55186. 1 hit.
    SSF81271. SSF81271. 1 hit.
    TIGRFAMsi TIGR00418. thrS. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

    Entry informationi

    Entry nameiSYT_RHOS4
    AccessioniPrimary (citable) accession number: Q3J0X4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3