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Reviewed, UniProtKB/Swiss-Prot Q3J079 (HISX1_RHOS4)

Last modified November 25, 2008. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Histidinol dehydrogenase 1
      Short name=HDH 1
    EC=1.1.1.23
Gene names
Name: hisD1
Ordered Locus Names: RHOS4_22370
ORF Names: RSP_0632
OrganismRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Complete proteome] [HAMAP]
Taxonomic identifier272943 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

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Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.

Catalytic activity

L-histidinol + 2 NAD(+) = L-histidine + 2 NADH.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.

Sequence similarities

Belongs to the histidinol dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Histidinol dehydrogenase 1
PRO_0000229863

Sites

Active site3271Proton acceptor By similarity
Active site3281Proton acceptor By similarity
Metal binding2591Zinc By similarity
Metal binding2621Zinc By similarity
Metal binding3611Zinc By similarity
Metal binding4201Zinc By similarity
Binding site1301NAD By similarity
Binding site1911NAD By similarity
Binding site2141NAD By similarity
Binding site2371Substrate By similarity
Binding site2591Substrate By similarity
Binding site2621Substrate By similarity
Binding site3281Substrate By similarity
Binding site3611Substrate By similarity
Binding site4151Substrate By similarity
Binding site4201Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q3J079-1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 5B5E5AE935E404B4

FASTA43445,962
        10         20         30         40         50         60 
MPQFLDTRRP GFEADFTALL GMKREDSPDV DAVVAGIIAD VRARGDAAVI ELTARFDRLE 

        70         80         90        100        110        120 
LTPERLAFSE AEIEAEIATV SAEDRAALEL AAERIRAYHA RQMPENARWT DAAGAELGWR 

       130        140        150        160        170        180 
WGPIASAGLY VPGGLASYPS SVLMNAIPAR VAGVERLVVA CPTPGGVVNP LVLLAARLAG 

       190        200        210        220        230        240 
VDAVYRIGGA QAVAALAYGT ETIRPVDKIT GPGNAYVAAA KRRVFGRVGI DMIAGPSEIL 

       250        260        270        280        290        300 
VIAEGAVDPD WIALDLLSQA EHDESAQSIL VTPDEALGRA VVQAVEARLE TLERRAIAGA 

       310        320        330        340        350        360 
SWRDYGAVIV TRDLEEAAAL SDRVAPEHLE LCVADPEALA ARIRHAGAIF LGGWTPEAIG 

       370        380        390        400        410        420 
DYVGGPNHVL PTARSARFSS GLSVMDFLKR TTLARMTPAA LRAVGPAAER LAISESLEAH 

       430 
GLSVRARLDR LNEG

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References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

CP000143 Genomic DNA. Translation: ABA79805.1.
RefSeqYP_353706.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID3718260.
GenomeReviewsGene locus RHOS4_22370 in contig CP000143_GR.
KEGGrsp:RSP_0632.
NMPDRfig|272943.3.peg.2857.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ3J079.

Enzyme and pathway databases

BioCycRSPH272943:RSP_0632-MON.

Family and domain databases

HAMAPMF_01024.
[Tree]
InterProIPR001692. Histidinol_DHase.
IPR012131. Hstdl_DHase_prok.
[Graphical view]
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSPR00083. HOLDHDRGNASE.
ProDomPD002680. Histidinol_dh. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR00069. hisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameHISX1_RHOS4
AccessionPrimary (citable) accession number: Q3J079
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: November 25, 2008
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents