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Q3J047

- FTHS_RHOS4

UniProt

Q3J047 - FTHS_RHOS4

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSPH272943:GJAS-2327-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:RHOS4_22690
    ORF Names:RSP_0663
    OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
    Taxonomic identifieri272943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002703: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000300534Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272943.RSP_0663.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3J047.
    SMRiQ3J047. Positions 6-555.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIANSVSM.
    OrthoDBiEOG6PCPSP.
    PhylomeDBiQ3J047.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3J047-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVQTDIEIA RAARKKPIQE IGAGLGIPAE ALIPYGHDKA KVGQGFIRGL    50
    EGRPDGKLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKK AVICIREASL 100
    GPNFGMKGGA AGGGRAQVVP MEDMNLHFTG DFHAITAAHN LLAAMIDNHI 150
    YWGNALELDA RRITWRRVMD MNDRALRDTV VNLGGVANGF PRQTGFDITV 200
    ASEVMAILCL ADDLEDLERR LGRIVVGYRR DKSPVYCRDL KAAGAMAVLL 250
    KDAMQPNLVQ TIENNPAFVH GGPFANIAHG CNSVIATRTA LKLADYVVTE 300
    AGFGADLGAE KFFDIKCRLA GLKPSAAVVV ATVRALKMNG GVAREDLGRE 350
    DVAALRRGCA NLGRHIANVK GFGVPVVVAI NHFTTDTEAE IEAVRAYAAG 400
    QGAEAFLCRH WAEGSAGIED LAQKVVELAE TPSMFAPLYP DDMPLFEKME 450
    TVARRIYHAH DVIADHVIRD QLRTWEEAGY GALPVCMAKT QYSFTTDAAI 500
    RGAPEGHSIP IREVRLAAGA GFVVAICGEI RTMPGLPSQP AAELIHLDEE 550
    GRIEGLF 557
    Length:557
    Mass (Da):59,619
    Last modified:November 8, 2005 - v1
    Checksum:i70FA3F19090AF783
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA79837.1.
    RefSeqiYP_353738.1. NC_007493.2.

    Genome annotation databases

    EnsemblBacteriaiABA79837; ABA79837; RSP_0663.
    GeneIDi3718273.
    KEGGirsp:RSP_0663.
    PATRICi23154485. VBIRhoSph57909_2613.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000143 Genomic DNA. Translation: ABA79837.1 .
    RefSeqi YP_353738.1. NC_007493.2.

    3D structure databases

    ProteinModelPortali Q3J047.
    SMRi Q3J047. Positions 6-555.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272943.RSP_0663.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA79837 ; ABA79837 ; RSP_0663 .
    GeneIDi 3718273.
    KEGGi rsp:RSP_0663.
    PATRICi 23154485. VBIRhoSph57909_2613.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IANSVSM.
    OrthoDBi EOG6PCPSP.
    PhylomeDBi Q3J047.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RSPH272943:GJAS-2327-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

    Entry informationi

    Entry nameiFTHS_RHOS4
    AccessioniPrimary (citable) accession number: Q3J047
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3