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Q3J047

- FTHS_RHOS4

UniProt

Q3J047 - FTHS_RHOS4

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-2327-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:RHOS4_22690
ORF Names:RSP_0663
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 557557Formate--tetrahydrofolate ligasePRO_0000300534Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_0663.

Structurei

3D structure databases

ProteinModelPortaliQ3J047.
SMRiQ3J047. Positions 6-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIANSVSM.
OrthoDBiEOG6PCPSP.
PhylomeDBiQ3J047.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3J047-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVQTDIEIA RAARKKPIQE IGAGLGIPAE ALIPYGHDKA KVGQGFIRGL
60 70 80 90 100
EGRPDGKLIL VTAINPTPAG EGKTTTTVGL GDGLNRIGKK AVICIREASL
110 120 130 140 150
GPNFGMKGGA AGGGRAQVVP MEDMNLHFTG DFHAITAAHN LLAAMIDNHI
160 170 180 190 200
YWGNALELDA RRITWRRVMD MNDRALRDTV VNLGGVANGF PRQTGFDITV
210 220 230 240 250
ASEVMAILCL ADDLEDLERR LGRIVVGYRR DKSPVYCRDL KAAGAMAVLL
260 270 280 290 300
KDAMQPNLVQ TIENNPAFVH GGPFANIAHG CNSVIATRTA LKLADYVVTE
310 320 330 340 350
AGFGADLGAE KFFDIKCRLA GLKPSAAVVV ATVRALKMNG GVAREDLGRE
360 370 380 390 400
DVAALRRGCA NLGRHIANVK GFGVPVVVAI NHFTTDTEAE IEAVRAYAAG
410 420 430 440 450
QGAEAFLCRH WAEGSAGIED LAQKVVELAE TPSMFAPLYP DDMPLFEKME
460 470 480 490 500
TVARRIYHAH DVIADHVIRD QLRTWEEAGY GALPVCMAKT QYSFTTDAAI
510 520 530 540 550
RGAPEGHSIP IREVRLAAGA GFVVAICGEI RTMPGLPSQP AAELIHLDEE

GRIEGLF
Length:557
Mass (Da):59,619
Last modified:November 8, 2005 - v1
Checksum:i70FA3F19090AF783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA79837.1.
RefSeqiYP_353738.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA79837; ABA79837; RSP_0663.
GeneIDi3718273.
KEGGirsp:RSP_0663.
PATRICi23154485. VBIRhoSph57909_2613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA79837.1 .
RefSeqi YP_353738.1. NC_007493.2.

3D structure databases

ProteinModelPortali Q3J047.
SMRi Q3J047. Positions 6-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272943.RSP_0663.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA79837 ; ABA79837 ; RSP_0663 .
GeneIDi 3718273.
KEGGi rsp:RSP_0663.
PATRICi 23154485. VBIRhoSph57909_2613.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IANSVSM.
OrthoDBi EOG6PCPSP.
PhylomeDBi Q3J047.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RSPH272943:GJAS-2327-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiFTHS_RHOS4
AccessioniPrimary (citable) accession number: Q3J047
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3