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Protein

Pyrroloquinoline-quinone synthase

Gene

pqqC

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ.UniRule annotation

Catalytic activityi

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O.UniRule annotation

Pathwayi: pyrroloquinoline quinone biosynthesis

This protein is involved in the pathway pyrroloquinoline quinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pyrroloquinoline quinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

PQQ biosynthesis

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-2461-MONOMER.
UniPathwayiUPA00539.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyrroloquinoline-quinone synthaseUniRule annotation (EC:1.3.3.11UniRule annotation)
Alternative name(s):
Coenzyme PQQ synthesis protein CUniRule annotation
Pyrroloquinoline quinone biosynthesis protein CUniRule annotation
Gene namesi
Name:pqqCUniRule annotation
Ordered Locus Names:RHOS4_24010
ORF Names:RSP_0792
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255Pyrroloquinoline-quinone synthasePRO_1000061678Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_0792.

Structurei

3D structure databases

ProteinModelPortaliQ3IZR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PqqC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiPOG091H0KR9.
PhylomeDBiQ3IZR5.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IZR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDLSTSLS PARPLESADA MEERLREIGA ARYHDRHPFH HMLHGGELTK
60 70 80 90 100
GQVQAWALNR YYYQCTIPVK DAVVISRFRD RATRIEWRHR LEDHDGAEGA
110 120 130 140 150
EGGIDRWLIL TDGLGLDRAY VESTEGILPA TRFAVEAYVH FVRDRSPLEA
160 170 180 190 200
IASCLTELFA PNIHATRISG MLSHYDFINP TVMAYFQRRL TQAPRDADYA
210 220 230 240 250
LRYVRDHART PEERAAVCNA LIFKTQVLWT QLDALHHAYV LGHVPPGAFV

PEEMR
Length:255
Mass (Da):29,104
Last modified:November 8, 2005 - v1
Checksum:i639782EE9707EF16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA79969.1.
RefSeqiWP_011338492.1. NZ_AKVW01000001.1.
YP_353870.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA79969; ABA79969; RSP_0792.
GeneIDi3718408.
KEGGirsp:RSP_0792.
PATRICi23154761. VBIRhoSph57909_2750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA79969.1.
RefSeqiWP_011338492.1. NZ_AKVW01000001.1.
YP_353870.1. NC_007493.2.

3D structure databases

ProteinModelPortaliQ3IZR5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_0792.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA79969; ABA79969; RSP_0792.
GeneIDi3718408.
KEGGirsp:RSP_0792.
PATRICi23154761. VBIRhoSph57909_2750.

Phylogenomic databases

eggNOGiENOG41086XE. Bacteria.
COG5424. LUCA.
HOGENOMiHOG000217947.
KOiK06137.
OMAiCNALIFK.
OrthoDBiPOG091H0KR9.
PhylomeDBiQ3IZR5.

Enzyme and pathway databases

UniPathwayiUPA00539.
BioCyciRSPH272943:GJAS-2461-MONOMER.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
HAMAPiMF_00654. PQQ_syn_PqqC. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. Thiaminase-2/PQQC.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPQQC_RHOS4
AccessioniPrimary (citable) accession number: Q3IZR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.