Reviewed, UniProtKB/Swiss-Prot Q3IZR5 (PQQC_RHOS4)

Names and origin

Protein names

Recommended name:
    Pyrroloquinoline-quinone synthase
    EC=1.3.3.11
Alternative name(s):
    Coenzyme PQQ synthesis protein C
    Pyrroloquinoline quinone biosynthesis protein C

Gene names

Name:	pqqC
Ordered Locus Names:	RHOS4_24010
ORF Names:	RSP_0792

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Complete proteome] [HAMAP]

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity.
Catalytic activity	6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O(2) = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H(2)O(2) + 2 H(2)O.
Pathway	Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
Sequence similarities	Belongs to the pqqC family.

Ontologies

Keywords
Biological process	PQQ biosynthesis
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyrroloquinoline quinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	pyrroloquinoline-quinone synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	Pyrroloquinoline-quinone synthase		PRO_1000061678

Sequences

	Sequence		Length	Mass (Da)
	Q3IZR5-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 639782EE9707EF16	FASTA	255	29,104
	10 20 30 40 50 60 MSLDLSTSLS PARPLESADA MEERLREIGA ARYHDRHPFH HMLHGGELTK GQVQAWALNR 70 80 90 100 110 120 YYYQCTIPVK DAVVISRFRD RATRIEWRHR LEDHDGAEGA EGGIDRWLIL TDGLGLDRAY 130 140 150 160 170 180 VESTEGILPA TRFAVEAYVH FVRDRSPLEA IASCLTELFA PNIHATRISG MLSHYDFINP 190 200 210 220 230 240 TVMAYFQRRL TQAPRDADYA LRYVRDHART PEERAAVCNA LIFKTQVLWT QLDALHHAYV 250 LGHVPPGAFV PEEMR

References

[1]

"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000143 Genomic DNA. Translation: ABA79969.1.
RefSeq	YP_353870.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3718408.
GenomeReviews	Gene locus RHOS4_24010 in contig CP000143_GR.
KEGG	rsp:RSP_0792.
NMPDR	fig|272943.3.peg.2379.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q3IZR5.
Enzyme and pathway databases
BioCyc	RSPH272943:RSP_0792-MON.
Family and domain databases
HAMAP	MF_00654. [Tree]
InterPro	IPR016084. Haem_Oase-like_multi-hlx. IPR011845. PQQ_synth_PqqC. IPR004305. TENA/THI4/PQQ_synth_PqqC. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
Pfam	PF03070. TENA_THI-4. 1 hit. [Graphical view]
TIGRFAMs	TIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PQQC_RHOS4

Accession

Primary (citable) accession number: Q3IZR5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 8, 2005
Last modified:	November 4, 2008
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)