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Q3IZR5 (PQQC_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyrroloquinoline-quinone synthase
EC=1.3.3.11
Alternative name(s):
Coenzyme PQQ synthesis protein C
Pyrroloquinoline quinone biosynthesis protein C
Gene names
Name:pqqC
Ordered Locus Names:RHOS4_24010
ORF Names:RSP_0792
OrganismRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifier272943 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ By similarity. HAMAP MF_00654

Catalytic activity

6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O. HAMAP MF_00654

Pathway

Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis. HAMAP MF_00654

Sequence similarities

Belongs to the pqqC family.

Ontologies

Keywords
   Biological processPQQ biosynthesis
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpyrroloquinoline quinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionpyrroloquinoline-quinone synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 255255Pyrroloquinoline-quinone synthase HAMAP MF_00654
PRO_1000061678

Sequences

Sequence LengthMass (Da)Tools
Q3IZR5 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 639782EE9707EF16

FASTA25529,104
        10         20         30         40         50         60 
MSLDLSTSLS PARPLESADA MEERLREIGA ARYHDRHPFH HMLHGGELTK GQVQAWALNR 

        70         80         90        100        110        120 
YYYQCTIPVK DAVVISRFRD RATRIEWRHR LEDHDGAEGA EGGIDRWLIL TDGLGLDRAY 

       130        140        150        160        170        180 
VESTEGILPA TRFAVEAYVH FVRDRSPLEA IASCLTELFA PNIHATRISG MLSHYDFINP 

       190        200        210        220        230        240 
TVMAYFQRRL TQAPRDADYA LRYVRDHART PEERAAVCNA LIFKTQVLWT QLDALHHAYV 

       250 
LGHVPPGAFV PEEMR

« Hide

References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000143 Genomic DNA. Translation: ABA79969.1.
RefSeqYP_353870.1. NC_007493.1.

3D structure databases

ProteinModelPortalQ3IZR5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3IZR5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3718408.
GenomeReviewsGene locus RHOS4_24010 in contig CP000143_GR.
KEGGrsp:RSP_0792.
NMPDRfig|272943.3.peg.2379.
PATRIC23154761. VBIRhoSph57909_2750.

Phylogenomic databases

eggNOGCOG5424.
HOGENOMHBG288944.
OMAFRDRATR.
ProtClustDBPRK05157.

Enzyme and pathway databases

BioCycRSPH272943:RSP_0792-MONOMER.

Family and domain databases

HAMAPMF_00654. PQQ_syn_PqqC.
[Tree]
InterProIPR016084. Haem_Oase-like_multi-hlx.
IPR011845. PQQ_synth_PqqC.
IPR004305. TENA/THI4/PQQ_synthPqqC_dom.
[Graphical view]
Gene3DG3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
KOK06137.
PfamPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMSSF48613. Heme_oxygenase. 1 hit.
TIGRFAMsTIGR02111. PQQ_syn_pqqC. 1 hit.
ProtoNetSearch...

Entry information

Entry namePQQC_RHOS4
AccessionPrimary (citable) accession number: Q3IZR5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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