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Protein

NAD kinase

Gene

nadK

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44Proton acceptorUniRule annotation1
Binding sitei144NADUniRule annotation1
Binding sitei152NAD; via carbonyl oxygenUniRule annotation1
Binding sitei179NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 45NADUniRule annotation2
Nucleotide bindingi114 – 115NADUniRule annotation2
Nucleotide bindingi155 – 160NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:RHOS4_24350, RSP_0825
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000054351 – 254NAD kinaseAdd BLAST254

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_0825.

Structurei

3D structure databases

ProteinModelPortaliQ3IZN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000139847.
KOiK00858.
OMAiNGIERMS.
OrthoDBiPOG091H02D1.
PhylomeDBiQ3IZN1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiView protein in Pfam
PF01513. NAD_kinase. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IZN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPQRIGFVA SNAPVAQEAL NVMAARYGQC PLPEADAIVA LGGDGFMLQT
60 70 80 90 100
LHETQSLDIP VYGMNRGTVG FLMNGYAEDG LRERLAEAEE EILNPLAMTA
110 120 130 140 150
VTGAGEVFHR IAINEVSLLR AGPQAAWLKI SVDGKVRMEE LVCDGALVCT
160 170 180 190 200
PAGSTAYNYS AHGPILPIGA DVLALTAIAP FRPRRWRGAL LPKTALVRFD
210 220 230 240 250
VIDAQKRPVM ADADGRSVRD VVSVEIRTEP AVRHRLLFDP GHGLEERLIR

EQFV
Length:254
Mass (Da):27,522
Last modified:November 8, 2005 - v1
Checksum:i4619AA5A6AE18F1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA80003.1.
RefSeqiWP_011338520.1. NZ_AKVW01000001.1.
YP_353904.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA80003; ABA80003; RSP_0825.
GeneIDi3718403.
KEGGirsp:RSP_0825.
PATRICifig|272943.9.peg.2786.

Similar proteinsi

Entry informationi

Entry nameiNADK_RHOS4
AccessioniPrimary (citable) accession number: Q3IZN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families