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Q3IZN1

- NADK_RHOS4

UniProt

Q3IZN1 - NADK_RHOS4

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Protein
NAD kinase
Gene
nadK, RHOS4_24350, RSP_0825
Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Proton acceptor By similarity
Binding sitei144 – 1441NAD By similarity
Binding sitei152 – 1521NAD; via carbonyl oxygen By similarity
Binding sitei179 – 1791NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 452NAD By similarity
Nucleotide bindingi114 – 1152NAD By similarity
Nucleotide bindingi155 – 1606NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSPH272943:GJAS-2495-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:RHOS4_24350, RSP_0825
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
ProteomesiUP000002703: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254NAD kinaseUniRule annotation
PRO_1000005435Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_0825.

Structurei

3D structure databases

ProteinModelPortaliQ3IZN1.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000139847.
KOiK00858.
OMAiMNGYAED.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ3IZN1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IZN1-1 [UniParc]FASTAAdd to Basket

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MTPQRIGFVA SNAPVAQEAL NVMAARYGQC PLPEADAIVA LGGDGFMLQT    50
LHETQSLDIP VYGMNRGTVG FLMNGYAEDG LRERLAEAEE EILNPLAMTA 100
VTGAGEVFHR IAINEVSLLR AGPQAAWLKI SVDGKVRMEE LVCDGALVCT 150
PAGSTAYNYS AHGPILPIGA DVLALTAIAP FRPRRWRGAL LPKTALVRFD 200
VIDAQKRPVM ADADGRSVRD VVSVEIRTEP AVRHRLLFDP GHGLEERLIR 250
EQFV 254
Length:254
Mass (Da):27,522
Last modified:November 8, 2005 - v1
Checksum:i4619AA5A6AE18F1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA80003.1.
RefSeqiWP_011338520.1. NZ_AKVW01000001.1.
YP_353904.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA80003; ABA80003; RSP_0825.
GeneIDi3718403.
KEGGirsp:RSP_0825.
PATRICi23154833. VBIRhoSph57909_2786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000143 Genomic DNA. Translation: ABA80003.1 .
RefSeqi WP_011338520.1. NZ_AKVW01000001.1.
YP_353904.1. NC_007493.2.

3D structure databases

ProteinModelPortali Q3IZN1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272943.RSP_0825.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABA80003 ; ABA80003 ; RSP_0825 .
GeneIDi 3718403.
KEGGi rsp:RSP_0825.
PATRICi 23154833. VBIRhoSph57909_2786.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000139847.
KOi K00858.
OMAi MNGYAED.
OrthoDBi EOG6PZXDR.
PhylomeDBi Q3IZN1.

Enzyme and pathway databases

BioCyci RSPH272943:GJAS-2495-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Entry informationi

Entry nameiNADK_RHOS4
AccessioniPrimary (citable) accession number: Q3IZN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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