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Protein

Malate dehydrogenase

Gene

mdh

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:RHOS4_25830
ORF Names:RSP_0968
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419611 – 320Malate dehydrogenaseAdd BLAST320

Interactioni

Protein-protein interaction databases

STRINGi272943.RSP_0968

Structurei

3D structure databases

ProteinModelPortaliQ3IZ83
SMRiQ3IZ83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiQCTPKVE
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q3IZ83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPKIALIG AGQIGGTLAH LAAIKELGDV VLFDIAEGTP QGKALDIAQS
60 70 80 90 100
GPSEGFDAVM KGANSYEEIA GADVCIVTAG VPRKPGMSRD DLIGINLKVM
110 120 130 140 150
KSVGEGIKAH APNAFVICIT NPLDAMVWAL QQFSGLPAEK VVGMAGVLDS
160 170 180 190 200
ARFRHFLSVE FNVSMRDVTA FVLGGHGDTM VPLVRYSTVA GIPLPDLVQM
210 220 230 240 250
GWTTQEKLDQ IVQRTRDGGA EIVGLLKTGS AFYAPATSAI EMAEAYLKDQ
260 270 280 290 300
KRLLPCAAYV DGAFGLNGMY VGVPTIIGAG GIEKIVDIKL NDDEQAMFDK
310 320
SVNAVKGLVE ACKGIDSSLA
Length:320
Mass (Da):33,564
Last modified:June 27, 2006 - v2
Checksum:i98384A81FDD12753
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA Translation: ABA80151.2
RefSeqiWP_002721256.1, NZ_AKVW01000001.1
YP_354052.4, NC_007493.2

Genome annotation databases

EnsemblBacteriaiABA80151; ABA80151; RSP_0968
GeneIDi3720759
KEGGirsp:RSP_0968
PATRICifig|272943.9.peg.2940

Similar proteinsi

Entry informationi

Entry nameiMDH_RHOS4
AccessioniPrimary (citable) accession number: Q3IZ83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: March 28, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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