Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q3IYX7 (PGSA_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

EC=2.7.8.5
Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase
Gene names
Name:pgsA
Ordered Locus Names:RHOS4_26890
ORF Names:RSP_1073
OrganismRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifier272943 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein catalyzes the committed step to the synthesis of the acidic phospholipids. Ref.1

Catalytic activity

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Sequence caution

The sequence AAC44003.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
PRO_0000239137

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane34 – 5421Helical; Potential
Transmembrane75 – 9521Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane187 – 20721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q3IYX7 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: CD9E26A04270B411

FASTA22124,683
        10         20         30         40         50         60 
MNWSIPNILT VLRLLAAPGV AVMFLYFHRP WADWFALTLF ILAAVTDFFD GYLARLWKQE 

        70         80         90        100        110        120 
SKFGAMLDPI ADKAMVVIAL VIITGYSGMN PWLILPVTLI LFREVFVSGL REFLGAKASL 

       130        140        150        160        170        180 
LKVTKLAKWK TTAQMVAIAI LFLGTGLEHL EGIARQGMTW EQYARAVSAG EADPIRSCGM 

       190        200        210        220 
HGCSSYATWL GLALIWIAAA LTFITGWDYF RKALPYLKDE K 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and expression of the Rhodobacter sphaeroides gene (pgsA) encoding phosphatidylglycerophosphate synthase."
Dryden S.C., Dowhan W.
J. Bacteriol. 178:1030-1038(1996) [PubMed: 8576035] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29587 Genomic DNA. Translation: AAC44003.1. Different initiation.
CP000143 Genomic DNA. Translation: ABA80257.1.
RefSeqYP_354158.1. NC_007493.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ3IYX7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3720888.
GenomeReviewsGene locus RHOS4_26890 in contig CP000143_GR.
KEGGrsp:RSP_1073.
NMPDRfig|272943.3.peg.2293.
PATRIC23155363. VBIRhoSph57909_3047.

Phylogenomic databases

eggNOGCOG0558.
HOGENOMHBG686655.
OMAIDYTIKY.
PhylomeDBQ3IYX7.
ProtClustDBCLSK934237.

Enzyme and pathway databases

BioCycRSPH272943:RSP_1073-MONOMER.

Family and domain databases

InterProIPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
KOK00995.
PfamPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsTIGR00560. PgsA. 1 hit.
PROSITEPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGSA_RHOS4
AccessionPrimary (citable) accession number: Q3IYX7
Secondary accession number(s): Q53090
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 8, 2005
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families