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Reviewed, UniProtKB/Swiss-Prot Q3IYX7 (PGSA_RHOS4)

Last modified February 9, 2010. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase
Gene names
Name: pgsA
Ordered Locus Names: RHOS4_26890
ORF Names: RSP_1073
OrganismRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Complete proteome] [HAMAP]
Taxonomic identifier272943 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter

Protein attributes

Sequence length221 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

This protein catalyzes the committed step to the synthesis of the acidic phospholipids. Ref.1

Catalytic activity

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Pathway

Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionCDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 221221CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
PRO_0000239137

Regions

Transmembrane8 – 2821 Potential
Transmembrane34 – 5421 Potential
Transmembrane75 – 9521 Potential
Transmembrane133 – 15321 Potential
Transmembrane187 – 20721 Potential

Sequences

Sequence LengthMass (Da)Tools
Q3IYX7-1 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: CD9E26A04270B411

FASTA22124,683
        10         20         30         40         50         60 
MNWSIPNILT VLRLLAAPGV AVMFLYFHRP WADWFALTLF ILAAVTDFFD GYLARLWKQE 

        70         80         90        100        110        120 
SKFGAMLDPI ADKAMVVIAL VIITGYSGMN PWLILPVTLI LFREVFVSGL REFLGAKASL 

       130        140        150        160        170        180 
LKVTKLAKWK TTAQMVAIAI LFLGTGLEHL EGIARQGMTW EQYARAVSAG EADPIRSCGM 

       190        200        210        220 
HGCSSYATWL GLALIWIAAA LTFITGWDYF RKALPYLKDE K 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and expression of the Rhodobacter sphaeroides gene (pgsA) encoding phosphatidylglycerophosphate synthase."
Dryden S.C., Dowhan W.
J. Bacteriol. 178:1030-1038(1996) [PubMed: 8576035] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29587 Genomic DNA. Translation: AAC44003.1. Different initiation.
CP000143 Genomic DNA. Translation: ABA80257.1.
RefSeqYP_354158.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ3IYX7.

Genome annotation databases

GeneID3720888.
GenomeReviewsGene locus RHOS4_26890 in contig CP000143_GR.
KEGGrsp:RSP_1073.
NMPDRfig|272943.3.peg.2293.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0558.
HOGENOMHBG686655.
OMATSNIGRM.
PhylomeDBQ3IYX7.

Enzyme and pathway databases

BioCycRSPH272943:RSP_1073-MONOMER.

Family and domain databases

InterProIPR000462. CDP-OH_P_trans.
IPR004570. Phosphatidylglycerol_P_synth.
[Graphical view]
PfamPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFPIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMsTIGR00560. pgsA. 1 hit.
PROSITEPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGSA_RHOS4
AccessionPrimary (citable) accession number: Q3IYX7
Secondary accession number(s): Q53090
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 8, 2005
Last modified: February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents