Reviewed, UniProtKB/Swiss-Prot Q3IYX7 (PGSA_RHOS4)

Names and origin

Protein names

Recommended name:
    CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
    EC=2.7.8.5
Alternative name(s):
    Phosphatidylglycerophosphate synthase
      Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	RHOS4_26890
ORF Names:	RSP_1073

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) [Complete proteome] [HAMAP]

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids. Ref.1
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein Ref.1.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000239137
Regions
	Transmembrane	8 – 28	21	Potential
	Transmembrane	34 – 54	21	Potential
	Transmembrane	75 – 95	21	Potential
	Transmembrane	133 – 153	21	Potential
	Transmembrane	187 – 207	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3IYX7-1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: CD9E26A04270B411	FASTA	221	24,683
	10 20 30 40 50 60 MNWSIPNILT VLRLLAAPGV AVMFLYFHRP WADWFALTLF ILAAVTDFFD GYLARLWKQE 70 80 90 100 110 120 SKFGAMLDPI ADKAMVVIAL VIITGYSGMN PWLILPVTLI LFREVFVSGL REFLGAKASL 130 140 150 160 170 180 LKVTKLAKWK TTAQMVAIAI LFLGTGLEHL EGIARQGMTW EQYARAVSAG EADPIRSCGM 190 200 210 220 HGCSSYATWL GLALIWIAAA LTFITGWDYF RKALPYLKDE K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and expression of the Rhodobacter sphaeroides gene (pgsA) encoding phosphatidylglycerophosphate synthase." Dryden S.C., Dowhan W. J. Bacteriol. 178:1030-1038(1996) [PubMed: 8576035] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION.
[2]	"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U29587 Genomic DNA. Translation: AAC44003.1. Different initiation. CP000143 Genomic DNA. Translation: ABA80257.1.
RefSeq	YP_354158.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IYX7.
Genome annotation databases
GeneID	3720888.
GenomeReviews	Gene locus RHOS4_26890 in contig CP000143_GR.
KEGG	rsp:RSP_1073.
NMPDR	fig|272943.3.peg.2293.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0558.
HOGENOM	HBG686655.
OMA	TSNIGRM.
PhylomeDB	Q3IYX7.
Enzyme and pathway databases
BioCyc	RSPH272943:RSP_1073-MONOMER.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. pgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_RHOS4

Accession

Primary (citable) accession number: Q3IYX7
Secondary accession number(s): Q53090

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2006
Last sequence update:	November 8, 2005
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)