Q3IYR6 (DXS2_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase 2
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase 2
Short name=DXP synthase 2
Short name=DXPS 2

Gene names

Name:	dxs2
Ordered Locus Names:	RHOS4_27500
ORF Names:	RSP_1134

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	637 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 637	637	1-deoxy-D-xylulose-5-phosphate synthase 2 HAMAP MF_00315		PRO_0000256476

Sequences

	Sequence		Length	Mass (Da)
	Q3IYR6 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: CEAB91AF70FD410D	FASTA	637	67,517
	10 20 30 40 50 60 MTDRPCTPTL DRVTLPVDIK GLTDRELRSL ADELRAETIS AVSVTGGHLG AGLGVVELTV 70 80 90 100 110 120 ALHAIFDAPR DKIIWDVGHQ CYPHKILTGR RDRIRTLRQG GGLSGFTKRS ESPYDCFGAG 130 140 150 160 170 180 HSSTSISAAV GFAAAREMGG DTGDAVAVIG DGSMSAGMAF EALNHGGHLK NRVIVILNDN 190 200 210 220 230 240 EMSIAPPVGA LSSYLSRLYA GAPFQDFKAA AKGALGLLPE PFQEGARRAK EMLKSVTVGG 250 260 270 280 290 300 TLFEELGFSY VGPIDGHDLD QLLPVLRTVK QRAHAPVLIH VITKKGRGYA PAEAARDRGH 310 320 330 340 350 360 ATNKFNVLTG AQVKPVSNAP SYTKVFAQSL IKEAEVDERI CAVTAAMPDG TGLNLFGERF 370 380 390 400 410 420 PKRTFDVGIA EQHAVTFSAA LAAGGMRPFC AIYSTFLQRG YDQIVHDVAI QRLPVRFAID 430 440 450 460 470 480 RAGLVGADGA THAGSFDVAF LSNLPGIVVM AAADEAELVH MVATAAAHDE GPIAFRYPRG 490 500 510 520 530 540 DGVGVEMPVK GVPLQIGRGR VVSEGTRIAL LSFGTRLAEV QVAAEALAAR GISPTVADAR 550 560 570 580 590 600 FAKPLDRDLI LQLAAHHEAL ITIEEGAIGG FGSHVAQLLA EAGVFDRGFR YRSMVLPDTF 610 620 630 IDHNSAEVMY ATAGLNAADI ERKALETLGV EVLARRA

References

[1]

"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000143 Genomic DNA. Translation: ABA80318.1.
RefSeq	YP_354219.1. NC_007493.1.
3D structure databases
ProteinModelPortal	Q3IYR6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IYR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3720832.
GenomeReviews	Gene locus RHOS4_27500 in contig CP000143_GR.
KEGG	rsp:RSP_1134.
NMPDR	fig|272943.3.peg.2463.
PATRIC	23155493. VBIRhoSph57909_3112.
Phylogenomic databases
eggNOG	COG1154.
HOGENOM	HBG571647.
OMA	EAMNAHA.
PhylomeDB	Q3IYR6.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	RSPH272943:RSP_1134-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS2_RHOS4

Accession

Primary (citable) accession number: Q3IYR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program