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Protein

Xylose isomerase

Gene

xylA

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99UniRule annotation1
Active sitei102UniRule annotation1
Metal bindingi230Magnesium 1UniRule annotation1
Metal bindingi266Magnesium 1UniRule annotation1
Metal bindingi266Magnesium 2UniRule annotation1
Metal bindingi269Magnesium 2UniRule annotation1
Metal bindingi294Magnesium 1UniRule annotation1
Metal bindingi305Magnesium 2UniRule annotation1
Metal bindingi307Magnesium 2UniRule annotation1
Metal bindingi337Magnesium 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:RHOS4_27920
ORF Names:RSP_1176
OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Taxonomic identifieri272943 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
Proteomesi
  • UP000002703 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002369691 – 433Xylose isomeraseAdd BLAST433

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272943.RSP_1176.

Structurei

3D structure databases

ProteinModelPortaliQ3IYM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.
PhylomeDBiQ3IYM4.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3IYM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDFFAGIPQ IRYEGEGSSN EFAFRHYNPD EVILGKRMED HLRFAVAWWH
60 70 80 90 100
SFAWPGGDPF GGQTFDRPWF GDTLDLAKLK ADVAFEMFDI LGAPFFCFHD
110 120 130 140 150
ADIRPEGATF AESKRNLEEI VDHIGIRMEG SKTKLLWGTA NLFSHRRFMS
160 170 180 190 200
GAATNPDPDV FAWSAATVKG CMDATMKLGG ANYVLWGGRE GYETLLNTDL
210 220 230 240 250
TREAENAGRF LQMVVDYKHK IGFQGTILIE PKPQEPSKHQ YDYDVATVYG
260 270 280 290 300
FLKRFGLEKE VKLNIEQGHA ILAGHSFEHE LALAASLGIL GSIDMNRNDY
310 320 330 340 350
QSGWDTDQFP HNHPEMALAY YEILRAGGFT TGGTNFDAKI RRQSLDPEDL
360 370 380 390 400
VLAHVGGMDT CARALKAAAR LYEDGSLETA RAARYAGWET PEAQAMLASS
410 420 430
LEKIEARVLA EGINPEPRSG RQERLENLWN RFV
Length:433
Mass (Da):48,563
Last modified:November 8, 2005 - v1
Checksum:i9577F5D500649F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA80360.1.
RefSeqiWP_011338767.1. NZ_AKVW01000001.1.
YP_354261.1. NC_007493.2.

Genome annotation databases

EnsemblBacteriaiABA80360; ABA80360; RSP_1176.
GeneIDi3718169.
KEGGirsp:RSP_1176.
PATRICi23155581. VBIRhoSph57909_3155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000143 Genomic DNA. Translation: ABA80360.1.
RefSeqiWP_011338767.1. NZ_AKVW01000001.1.
YP_354261.1. NC_007493.2.

3D structure databases

ProteinModelPortaliQ3IYM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272943.RSP_1176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABA80360; ABA80360; RSP_1176.
GeneIDi3718169.
KEGGirsp:RSP_1176.
PATRICi23155581. VBIRhoSph57909_3155.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.
OrthoDBiPOG091H07LC.
PhylomeDBiQ3IYM4.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_RHOS4
AccessioniPrimary (citable) accession number: Q3IYM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.