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Q3IYK5 (Q3IYK5_RHOS4) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323
EC=4.99.1.1 HAMAP MF_00323
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:HemH EMBL ABA80379.1
Synonyms:hemH HAMAP MF_00323
Ordered Locus Names:RHOS4_28110
ORF Names:RSP_1197 EMBL ABA80379.1
OrganismRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158) EMBL ABA80379.1
Taxonomic identifier272943 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323

Ontologies

Keywords
   Biological processHeme biosynthesis HAMAP MF_00323
Porphyrin biosynthesis HAMAP MF_00323
   Cellular componentCytoplasm HAMAP MF_00323
   LigandIron HAMAP MF_00323
Metal-binding HAMAP MF_00323
   Molecular functionLyase HAMAP MF_00323 EMBL ABA80379.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2441Iron By similarity HAMAP MF_00323
Metal binding3251Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
Q3IYK5 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 262885529923749F

FASTA37742,580
        10         20         30         40         50         60 
MSGSGMTPML QATPEQARTL GAEEPIRPGQ DRLAHAPADH PELPQPKIGI LLANLGTPDN 

        70         80         90        100        110        120 
YDYWSMRRYL NEFLSDKRVI DYPAWKWQPL LQILILSKRP FSSGANYKLI WNHDKGESPL 

       130        140        150        160        170        180 
MTITKDQTAA IAAEIRSLYG NRVMVDFCMR YGNPSTESRV RAMVEAGCEK ILFFPLYPHY 

       190        200        210        220        230        240 
AGATSATAND EFFRAMMKEK RQPAVRTVPE YYDNPLYIDA LAQSVERAYA QLDHRPDVLV 

       250        260        270        280        290        300 
ASYHGMPKRY LMAGDPYHCQ CAKTSRLLRE RLGWEKGAID TTFQSVFGPE EWLKPYTVEH 

       310        320        330        340        350        360 
VAELARAGKK RIAVIAPAFS ADCIETLEEI NGEIREAFEE AGGEEFTYIP CLNDDEAHIR 

       370 
ALVSVIEDNL AGWLARG

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References

[1]"Complete sequence of chromosome 1 of Rhodobacter sphaeroides 2.4.1."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000143 Genomic DNA. Translation: ABA80379.1.
RefSeqYP_354280.1. NC_007493.1.

3D structure databases

ProteinModelPortalQ3IYK5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ3IYK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3718861.
GenomeReviewsGene locus RHOS4_28110 in contig CP000143_GR.
KEGGrsp:RSP_1197.
NMPDRfig|272943.3.peg.2650.
PATRIC23155625. VBIRhoSph57909_3177.

Phylogenomic databases

eggNOGCOG0276.
HOGENOMHBG697135.
OMATIEEIGM.
PhylomeDBQ3IYK5.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycRSPH272943:RSP_1197-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ3IYK5_RHOS4
AccessionPrimary (citable) accession number: Q3IYK5
Entry history
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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