Q3IX44 (IOLG_RHOS4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	RHOS4_33220
ORF Names:	RSP_3283

Organism

Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

Taxonomic identifier

272943 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Rhodobacter

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.
Sequence caution	The sequence ABA80890.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352586

Sequences

	Sequence		Length	Mass (Da)
	Q3IX44 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: D7D8F11181FB1432	FASTA	334	36,118
	10 20 30 40 50 60 MTLRIGIIGT GAIGTDHARR INRVLSGAEV TAVTDVNRDS AEACVAGVAP GAQILGSAEE 70 80 90 100 110 120 VIAASDAVLV CSWGTAHETQ VLAAIAAGKP CFCEKPLATE AYGARRIVEA EEAMGRRLVQ 130 140 150 160 170 180 VGFMRRYDRG YVALKETVRT RLGPPLMIHA AHRNPSVPGR YRTPMAIHDT LIHEIDVLRW 190 200 210 220 230 240 LLDDEYVSAQ VIFPRATRHT HAGLRDPQIV LLETAKGVRI DVEIFVNCRY GYDIQCEVVG 250 260 270 280 290 300 EEGTARLPEP TAIPTRLGAV FGQPILMDWK DRFIDSYDVE LQDFLKAAAQ GTAAGPSAWD 310 320 330 GYAAAITADV CVQAQERPGA ILPVTLPARP ALYA

References

[1]

"Complete sequence of chromosome 2 of Rhodobacter sphaeroides 2.4.1." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000144 Genomic DNA. Translation: ABA80890.1. Different initiation.
RefSeq	YP_354791.1. NC_007494.1.
3D structure databases
ProteinModelPortal	Q3IX44.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IX44.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3721883.
GenomeReviews	Gene locus RHOS4_33220 in contig CP000144_GR.
KEGG	rsp:RSP_3283.
NMPDR	fig|272943.3.peg.3556.
PATRIC	23156723. VBIRhoSph57909_3709.
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
ProtClustDB	CLSK800746.
Enzyme and pathway databases
BioCyc	RSPH272943:RSP_3283-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RHOS4

Accession

Primary (citable) accession number: Q3IX44

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 14, 2008
Last modified:	January 25, 2012
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program