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Q3IW88

- TRMB_RHOS4

UniProt

Q3IW88 - TRMB_RHOS4

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei76 – 761S-adenosyl-L-methionineUniRule annotation
    Binding sitei101 – 1011S-adenosyl-L-methionineUniRule annotation
    Binding sitei128 – 1281S-adenosyl-L-methionineUniRule annotation
    Active sitei150 – 1501By similarity
    Binding sitei150 – 1501S-adenosyl-L-methionineUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Binding sitei186 – 1861SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRSPH272943:GJAS-3722-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:RHOS4_36280
    ORF Names:RSP_3593
    OrganismiRhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
    Taxonomic identifieri272943 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodobacteralesRhodobacteraceaeRhodobacter
    ProteomesiUP000002703: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 241241tRNA (guanine-N(7)-)-methyltransferasePRO_0000229191Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272943.RSP_3593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IW88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni219 – 2224Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073969.
    KOiK03439.
    OMAiYLTFIKK.
    OrthoDBiEOG6K6VBC.
    PhylomeDBiQ3IW88.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3IW88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDDDAPESL RGAADGPAWR NFYGRRSGKT LRPSQKVYLS EDLGRLRPEG    50
    ITREENPERR PLDLGALFGG RPVWLEIGFG GGEHMVHMAA RNPGIGLIGC 100
    EPFVNGVAML LGKIRAAGVE NLLVHPGDVR DLFDVLPEAS VSKAFLNYPD 150
    PWPKKRHHRR RFVTQGYLGP LARVLAPGAT FRVATDIPDY VRQTLEEVPQ 200
    AGFDLVSESG EAWEDWLSTR YEQKALREGR VPHYMTFRRQ G 241
    Length:241
    Mass (Da):26,988
    Last modified:November 8, 2005 - v1
    Checksum:iEC1B6E25470EFBB3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000144 Genomic DNA. Translation: ABA81196.1.
    RefSeqiWP_011339440.1. NZ_AKVW01000002.1.
    YP_355097.1. NC_007494.2.

    Genome annotation databases

    EnsemblBacteriaiABA81196; ABA81196; RSP_3593.
    GeneIDi3722110.
    KEGGirsp:RSP_3593.
    PATRICi23157369. VBIRhoSph57909_4029.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000144 Genomic DNA. Translation: ABA81196.1 .
    RefSeqi WP_011339440.1. NZ_AKVW01000002.1.
    YP_355097.1. NC_007494.2.

    3D structure databases

    ProteinModelPortali Q3IW88.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272943.RSP_3593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABA81196 ; ABA81196 ; RSP_3593 .
    GeneIDi 3722110.
    KEGGi rsp:RSP_3593.
    PATRICi 23157369. VBIRhoSph57909_4029.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073969.
    KOi K03439.
    OMAi YLTFIKK.
    OrthoDBi EOG6K6VBC.
    PhylomeDBi Q3IW88.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci RSPH272943:GJAS-3722-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome 2 of Rhodobacter sphaeroides 2.4.1."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Richardson P., Mackenzie C., Choudhary M., Larimer F., Hauser L.J., Land M., Donohue T.J., Kaplan S.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158.

    Entry informationi

    Entry nameiTRMB_RHOS4
    AccessioniPrimary (citable) accession number: Q3IW88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3