ID   G3P_NATPD               Reviewed;         338 AA.
AC   Q3IUT3;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase;
DE            Short=GAPDH;
DE            EC=1.2.1.59;
DE   AltName: Full=NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase;
GN   Name=gap; OrderedLocusNames=NP0012A;
OS   Natronomonas pharaonis (strain DSM 2160 / ATCC 35678).
OC   Archaea; Euryarchaeota; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Natronomonas.
OX   NCBI_TaxID=348780;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16169924; DOI=10.1101/gr.3952905;
RA   Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J.,
RA   Oesterhelt D.;
RT   "Living with two extremes: conclusions from the genome sequence of
RT   Natronomonas pharaonis.";
RL   Genome Res. 15:1336-1343(2005).
CC   -!- CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate + phosphate +
CC       NAD(P)(+) = 3-phospho-D-glyceroyl phosphate + NAD(P)H.
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 1/5.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate
CC       dehydrogenase family.
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DR   EMBL; CR936257; CAI48097.1; -; Genomic_DNA.
DR   RefSeq; YP_325669.1; -.
DR   GeneID; 3702737; -.
DR   GenomeReviews; CR936257_GR; NP0012A.
DR   KEGG; nph:NP0012A; -.
DR   NMPDR; fig|348780.3.peg.621; -.
DR   HOGENOM; Q3IUT3; -.
DR   OMA; Q3IUT3; AIFQGGE.
DR   BioCyc; NPHA348780:NP0012A-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043891; F:glyceraldehyde-3-phosphate dehydrogenase (N...; IEA:EC.
DR   GO; GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (p...; IEA:HAMAP.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0006096; P:glycolysis; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00559; -; 1.
DR   InterPro; IPR000173; GlycerAld_3-P_DH.
DR   InterPro; IPR006436; Glyceraldehyde-3-P_DH_2_arc.
DR   Pfam; PF02800; Gp_dh_C; 1.
DR   Pfam; PF00044; Gp_dh_N; 1.
DR   PIRSF; PIRSF000149; GAP_DH; 1.
DR   ProDom; PD007761; GAPDH_like; 1.
DR   TIGRFAMs; TIGR01546; GAPDH-II_archae; 1.
DR   PROSITE; PS00071; GAPDH; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
FT   CHAIN         1    338       Glyceraldehyde-3-phosphate dehydrogenase.
FT                                /FTId=PRO_0000232393.
FT   NP_BIND      12     13       NAD (By similarity).
FT   REGION      140    142       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   REGION      195    196       Glyceraldehyde 3-phosphate binding (By
FT                                similarity).
FT   ACT_SITE    141    141       Nucleophile (By similarity).
FT   BINDING     111    111       NAD; via amide nitrogen (By similarity).
FT   BINDING     169    169       NAD (By similarity).
FT   BINDING     302    302       NAD; via carbonyl oxygen (By similarity).
SQ   SEQUENCE   338 AA;  36122 MW;  9B67D5F6B9C526E7 CRC64;
     MSIQVAVNGY GTIGKRVADA VTLQPDMELV GVAKTSPNHE AELAVENDYP LYAAIEDRID
     DFEAAGIDLA GTVDELVEAA DIVVDACPSG IGADNKSLYE AHDTPALYQG GESADLVDVS
     FNARSNFEAA ADADHVRVVS CNTTGLSRLL APLQEEYGVE KARVTLVRRG GDPGQTGRGP
     INDILPNPVS LPSHHGPDVN TIFPDLDIDT LGLKVPATLM HTHSVNVTLE STPDAEAVAD
     LLDEQDRTFL IPESYGIDGA GKLKEFAMDR GRPRADIWEN CIWAESVSME GSDLYLFQAI
     HQESDVVPEN IDAIRAVLGT ADADESRETT NETLGVGL
//