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Q3IUQ6 (SYR_NATPD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:NP_0066A
OrganismNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis) [Complete proteome] [HAMAP]
Taxonomic identifier348780 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 580580Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242133

Regions

Motif123 – 13311"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q3IUQ6 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: 669BFEFF05D103AD

FASTA58064,494
        10         20         30         40         50         60 
MFIELRREVE TALSEALDAC GYPTDDLGIE EPPEDVDAVF ASSVAFRLAS AAEAPPPAVA 

        70         80         90        100        110        120 
GELAAELDAA GREYVGRIEQ QGPYLNFFPS EAYFEEALEA GQSERFGELD SKDTSVVVEH 

       130        140        150        160        170        180 
TSANPTGPVH VGRARNPIIG DAVANLLSYA GYDVDRHYYV NDAGRQMAVF TWAYETFDES 

       190        200        210        220        230        240 
DLPEPARDRA EYRMVRYYRK GNEYLENADP DAVEAAEAEI QDILQGLEDG DEATYERVGE 

       250        260        270        280        290        300 
VVDTVLDGMK ACLARLPAEF DEFVKETQFM RDGSTDDVVD RLQALDGAVY EDDAWQLAFA 

       310        320        330        340        350        360 
DIDKNLVFLR ADGTSLYTTR DIAHHEWKFD TYDRAVTVLG EDHKLQASQL RETLSLLGND 

       370        380        390        400        410        420 
VDQLDNVIYS YVNLPEGKMS TRRGTGVQLD DLLDEAIDRA REEVETRLGD RLRDDDLDEA 

       430        440        450        460        470        480 
DVERIAEQVG IGAVRYDIVA KQPSKAITFE WDRALDFEAQ SAPYVQYVHA RCCGILDEAD 

       490        500        510        520        530        540 
GLDPEATIAP LDTDAERDLL RTVARLPGVI ESAADDHQPH KIATYTRRLA DRFNTFYREC 

       550        560        570        580 
PVTTADDAEV RRARLALVAA ARHAMANALD ILGVEAPESM 

« Hide

References

[1]"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35678 / DSM 2160.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR936257 Genomic DNA. Translation: CAI48124.1.
RefSeqYP_325696.1. NC_007426.1.

3D structure databases

ProteinModelPortalQ3IUQ6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING348780.NP0066A.

Proteomic databases

PRIDEQ3IUQ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI48124; CAI48124; NP_0066A.
GeneID3702524.
KEGGnph:NP0066A.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247213.
KOK01887.
OMAMEHMGFG.

Enzyme and pathway databases

BioCycNPHA348780:GJX0-34-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_NATPD
AccessionPrimary (citable) accession number: Q3IUQ6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries