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Protein

DNA polymerase II large subunit

Gene

polC

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation
Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-247-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase II large subunitUniRule annotation (EC:2.7.7.7UniRule annotation)
Short name:
Pol IIUniRule annotation
Gene namesi
Name:polCUniRule annotation
Synonyms:polA2
Ordered Locus Names:NP_0476A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11981198DNA polymerase II large subunitPRO_0000294698Add
BLAST

Interactioni

Subunit structurei

Heterodimer of a large subunit and a small subunit.UniRule annotation

Protein-protein interaction databases

STRINGi348780.NP0476A.

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal DNA polymerase II family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IU54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREDDEQYFR RLESDLDTAL SVAREARKRG GDPTEDIEIP IAKDMADRVE
60 70 80 90 100
NILGIDGVAE RVREMEADPD LSREEAALEL AADFANDEVG DYETRAGKVE
110 120 130 140 150
GAVRTAVALL TEGVVAAPIE GIDRVELLEN DDGTEFINIY YAGPIRSAGG
160 170 180 190 200
TAQALSVLVA DYTRTLIGID EYKARNDETE RYAEELSLYD DETGLQYAPK
210 220 230 240 250
DEETKFIAEH MPIMLDGEAT GDEEVSGFRD LERVDTNSAR GGMCLVLGEG
260 270 280 290 300
IAQKAPKIQR YTSQLDEVDW PWLQDLIDGT YKTGEDTDEA DADSDDGTDE
310 320 330 340 350
DAADDSDIDD SSAGDEEADA PSGPPRPDPQ KKFLRDLIAG RPVFGHPSEP
360 370 380 390 400
GGFRLRYGRA RNHGFATAGV HPAAMHLIDD FLATGTQIKT ERPGKAAGVV
410 420 430 440 450
PVDTIEGPTV KLANGDVRRV DDPEEALEIR NGVEAILDLG EYLVNYGEFV
460 470 480 490 500
ENNHPLSPAA YAPEWWTQDL AAAGADVQAL ADSPRVDLEH PSAEQALEWA
510 520 530 540 550
ERYDAPLHPE YTYLWHDLDV ERFEALAAAA SEGHWAETDG AQQTRPPDGA
560 570 580 590 600
AESTLVVPRS EPVREALEVL LVEHTQGEET LTVPDAEPLV RSLGLTEGLE
610 620 630 640 650
RTWDELSTAA RSYDDGDNAV RAVNEVAPFE VRERAPTRIG CRMGRPEKSE
660 670 680 690 700
KRDLSPAVHT LFPIGEAGGS QRDIAEAATH AESMQDTPGE VEVQVGRRQC
710 720 730 740 750
PACDTETFRA RCPDCESVTD PRYVCYDCNI DVDPDESGRA ICPNCEREAD
760 770 780 790 800
AVQNRTVNVH EEYRSALSNV GERENAFDVL KGVKGLSSEH KVPEPIEKGV
810 820 830 840 850
LRAKHGVSAF KDGTVRYDMT DLPVTSVRAA ELDVTADQLR SLGYETDIHG
860 870 880 890 900
EPLTHEDQLV ELRVQDVVLS NGAAEHMLRT ADFVDDLLEQ YYGLEPFYDA
910 920 930 940 950
EDRDDIVGEL VFGMAPHTSA AVVGRVIGFT SAAVGYAHPY FHAAKRRNCD
960 970 980 990 1000
GDEDCVMLLL DGLLNFSKTF LPDQRGGRMD APLVMSSRID PAEIDDEAHN
1010 1020 1030 1040 1050
MDIVSSYPRA FFEATREMAD PGEVESLIQL GEDTLGTADE YRGFEHTHDT
1060 1070 1080 1090 1100
VDLAAGPDLS AYKTLGDMME KMDAQLELSR KLRSVDETDV AERVIEYHFL
1110 1120 1130 1140 1150
PDIIGNLRAF SRQETRCLDC GEKYRRVPLT GDCRECGGRV NLTVHQGSVN
1160 1170 1180 1190
KYIDTAIQVA EEYGCREYTK QRLRILDRAV ESIFEDDTNK QSGIADFM
Length:1,198
Mass (Da):132,156
Last modified:November 8, 2005 - v1
Checksum:i0F886B4A2B484FFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI48329.1.
RefSeqiWP_011321965.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI48329; CAI48329; NP_0476A.
GeneIDi3703041.
KEGGinph:NP_0476A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI48329.1.
RefSeqiWP_011321965.1. NC_007426.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi348780.NP0476A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI48329; CAI48329; NP_0476A.
GeneIDi3703041.
KEGGinph:NP_0476A.

Phylogenomic databases

eggNOGiarCOG04447. Archaea.
COG1933. LUCA.
HOGENOMiHOG000286435.
KOiK02322.
OMAiRNCDGDE.

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-247-MONOMER.

Family and domain databases

HAMAPiMF_00324. DNApol_II_L_arch. 1 hit.
InterProiIPR004475. PolC_DP2.
IPR016033. PolC_DP2_N.
[Graphical view]
PfamiPF03833. PolC_DP2. 1 hit.
[Graphical view]
PIRSFiPIRSF016275. PolC_DP2. 1 hit.
TIGRFAMsiTIGR00354. polC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDP2L_NATPD
AccessioniPrimary (citable) accession number: Q3IU54
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.