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Protein

Malate dehydrogenase

Gene

mdh

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NADBy similarity
Binding sitei83 – 831SubstrateBy similarity
Binding sitei89 – 891SubstrateBy similarity
Binding sitei96 – 961NADBy similarity
Binding sitei121 – 1211SubstrateBy similarity
Binding sitei152 – 1521SubstrateBy similarity
Active sitei176 – 1761Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 147NADBy similarity
Nucleotide bindingi119 – 1213NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:NP_0498A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Malate dehydrogenasePRO_0000241972Add
BLAST

Proteomic databases

PRIDEiQ3IU43.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP0498A.

Structurei

3D structure databases

ProteinModelPortaliQ3IU43.
SMRiQ3IU43. Positions 2-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
HOGENOMiHOG000213793.
KOiK00024.
OMAiITHYLQN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IU43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKVSIIGAA GTVGAAAGYN IALRDIADEL VFVDIPDQRE TTIGQAADAN
60 70 80 90 100
HGIAYDSNTT VVQGEYEDTA GSDVVVITAG IPRKEGQTRI DLAGDNAPIM
110 120 130 140 150
EDIGASLDEY NDDYVSITTS NPVDLLNRHL YEAGDRDRHK VIGFGGRLDS
160 170 180 190 200
ARFRYVLSER FDVPVQNVEA TILGEHGDAQ VPVFSKVRVD GADPEFDGDE
210 220 230 240 250
KEEILGDLQE SAMDVISRKG ATQWGPATGV AHMVEAVLND TGEVLPGSLV
260 270 280 290 300
LDGEYGYEDT AFGVPVKLGA NGIEEVVEWD LDDYESELMD DAAEKLSDQY

DKIS
Length:304
Mass (Da):32,719
Last modified:November 8, 2005 - v1
Checksum:i7F744512FA379A42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI48340.1.
RefSeqiWP_011321976.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI48340; CAI48340; NP_0498A.
GeneIDi3702903.
KEGGinph:NP_0498A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI48340.1.
RefSeqiWP_011321976.1. NC_007426.1.

3D structure databases

ProteinModelPortaliQ3IU43.
SMRiQ3IU43. Positions 2-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi348780.NP0498A.

Proteomic databases

PRIDEiQ3IU43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI48340; CAI48340; NP_0498A.
GeneIDi3702903.
KEGGinph:NP_0498A.

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
HOGENOMiHOG000213793.
KOiK00024.
OMAiITHYLQN.

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-258-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_NATPD
AccessioniPrimary (citable) accession number: Q3IU43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.