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Q3IU43

- MDH_NATPD

UniProt

Q3IU43 - MDH_NATPD

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Protein
Malate dehydrogenase
Gene
mdh, NP_0498A
Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei83 – 831Substrate By similarity
Binding sitei89 – 891Substrate By similarity
Binding sitei96 – 961NAD By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 147NAD By similarity
Nucleotide bindingi119 – 1213NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-258-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:NP_0498A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
ProteomesiUP000002698: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Malate dehydrogenaseUniRule annotation
PRO_0000241972Add
BLAST

Proteomic databases

PRIDEiQ3IU43.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP0498A.

Structurei

3D structure databases

ProteinModelPortaliQ3IU43.
SMRiQ3IU43. Positions 2-304.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213793.
KOiK00024.
OMAiPDILTYV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IU43-1 [UniParc]FASTAAdd to Basket

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MTKVSIIGAA GTVGAAAGYN IALRDIADEL VFVDIPDQRE TTIGQAADAN    50
HGIAYDSNTT VVQGEYEDTA GSDVVVITAG IPRKEGQTRI DLAGDNAPIM 100
EDIGASLDEY NDDYVSITTS NPVDLLNRHL YEAGDRDRHK VIGFGGRLDS 150
ARFRYVLSER FDVPVQNVEA TILGEHGDAQ VPVFSKVRVD GADPEFDGDE 200
KEEILGDLQE SAMDVISRKG ATQWGPATGV AHMVEAVLND TGEVLPGSLV 250
LDGEYGYEDT AFGVPVKLGA NGIEEVVEWD LDDYESELMD DAAEKLSDQY 300
DKIS 304
Length:304
Mass (Da):32,719
Last modified:November 8, 2005 - v1
Checksum:i7F744512FA379A42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI48340.1.
RefSeqiWP_011321976.1. NC_007426.1.
YP_325909.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI48340; CAI48340; NP_0498A.
GeneIDi3702903.
KEGGinph:NP0498A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI48340.1 .
RefSeqi WP_011321976.1. NC_007426.1.
YP_325909.1. NC_007426.1.

3D structure databases

ProteinModelPortali Q3IU43.
SMRi Q3IU43. Positions 2-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 348780.NP0498A.

Proteomic databases

PRIDEi Q3IU43.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI48340 ; CAI48340 ; NP_0498A .
GeneIDi 3702903.
KEGGi nph:NP0498A.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213793.
KOi K00024.
OMAi PDILTYV.

Enzyme and pathway databases

BioCyci NPHA348780:GJX0-258-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiMDH_NATPD
AccessioniPrimary (citable) accession number: Q3IU43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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