Q3ITI2 (Q3ITI2_NATPD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL CAI48551.1
Ordered Locus Names:	NP0920A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515 PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515 EMBL CAI48551.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	199	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	252	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	117	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	119	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	127	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	237	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	209	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	221	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	278	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	317	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q3ITI2 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 8B2E21C21080768C	FASTA	326	35,787
	10 20 30 40 50 60 MDLTDRPRRL RADGVRDLVS ETELHASDLI APIFVDATTD ERVEIESMPG HERVPVEEAV 70 80 90 100 110 120 PRTEEVLSTG VESVIVFGVP ESKDSEGSRA WADDGVVQRA VRAITDETDA YVITDVCFCE 130 140 150 160 170 180 YTDHGHCGIL ESDAAEDPHL TMDNDATLEL LRRTAVSHAE AGADMVAPSG MVDGMVGAIR 190 200 210 220 230 240 NALDAAGYEQ IPVMSYAAKY ESAFYGPFRD AADGAPSFGD RRHYQMDPAN AREARREVRL 250 260 270 280 290 300 DVEQGADVLM VKPALPYLDI VSELRREFDR PVAAYNVSGE YAMLHAAADR GWLDRQSVAH 310 320 ESLLSIKRAG ADLILTYFAE SVAERL

References

[1]	"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI48551.1.
RefSeq	YP_326120.1. NC_007426.1.
3D structure databases
ProteinModelPortal	Q3ITI2.
SMR	Q3ITI2. Positions 2-325.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ITI2.
Proteomic databases
PRIDE	Q3ITI2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3702806.
GenomeReviews	Gene locus NP0920A in contig CR936257_GR.
KEGG	nph:NP0920A.
NMPDR	fig|348780.3.peg.514.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05029.
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	Q3ITI2.
ProtClustDB	PRK09283.
Enzyme and pathway databases
BioCyc	NPHA348780:NP0920A-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q3ITI2_NATPD

Accession

Primary (citable) accession number: Q3ITI2

Entry history

Integrated into UniProtKB/TrEMBL:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)