Q3ISP9 (DAPB_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	NP1492A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228408

Sequences

	Sequence		Length	Mass (Da)
	Q3ISP9 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: AA1E41CDC11BAEC3	FASTA	246	26,301
	10 20 30 40 50 60 MNVVVVGATG RTGSEIVAEA SERGHDVSGV ARSQTSVGDV RVYPTEEFPE LLDNADAVID 70 80 90 100 110 120 FTVPEATREH VQAAAAAGVP YVIGTTGFDD DGMAALRTAS ESTAVLKASN FARGVQALLR 130 140 150 160 170 180 VVEAGVEALP EYDIELTETH HNGKRDAPSG TANTILDVVD ETRDEALDRT HGREGEHRRG 190 200 210 220 230 240 DDEVGVHVRR AGTVRGEHEL LLAGNDEVLS LTHRAESRRV FAAGAVDAAE WLADRSAGWY DFEDTV

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI48837.1.
RefSeq	YP_326404.1. NC_007426.1.
3D structure databases
ProteinModelPortal	Q3ISP9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ISP9.
Proteomic databases
PRIDE	Q3ISP9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3702657.
GenomeReviews	Gene locus NP1492A in contig CR936257_GR.
KEGG	nph:NP1492A.
NMPDR	fig|348780.3.peg.81.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05038.
HOGENOM	HBG594002.
OMA	IEISHKS.
PhylomeDB	Q3ISP9.
ProtClustDB	CLSK758622.
Enzyme and pathway databases
BioCyc	NPHA348780:NP1492A-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_NATPD

Accession

Primary (citable) accession number: Q3ISP9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 8, 2005
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program