Q3ISJ9 (F16PA_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	NP1592A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364776
Regions
	Region	89 – 92	4	Substrate binding By similarity
Sites
	Metal binding	67	1	Magnesium 1 By similarity
	Metal binding	86	1	Magnesium 1 By similarity
	Metal binding	86	1	Magnesium 2 By similarity
	Metal binding	88	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	89	1	Magnesium 2 By similarity
	Metal binding	231	1	Magnesium 2 By similarity
	Binding site	195	1	Substrate By similarity
	Binding site	225	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q3ISJ9 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: D5797BC01B0F4AB7	FASTA	283	30,157
	10 20 30 40 50 60 MADAIDDIVD VVVSTAPDVR DGLTGRRVYE ADENPSGERQ LEADVYADEL LEARLLDVDA 70 80 90 100 110 120 VGSYASEERE SVIEADEGGR YHVAADPLDG SSNLKSNNTM GTLFGVYEEP LPAAGDALVA 130 140 150 160 170 180 AGYVLYGPIT TLITARDGTV TESVIDEDGT RTVVTDDLTL PSDPVVYGFG GRVPNWTPAF 190 200 210 220 230 240 ADYVESVASE LKLRYGGAMI GDVNQVLTYG GVFGYPGLED RPEGKLRLLF EGHPIAAIVE 250 260 270 280 AAGGASSDGD GSLLKKEPEQ LHERTPLFVG NDEYIERLEA ALP

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI48887.1.
RefSeq	YP_326454.1. NC_007426.1.
3D structure databases
HSSP	HSSP built from PDB template 2GQ1 based on UniProtKB P0A993.
ProteinModelPortal	Q3ISJ9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3ISJ9.
Proteomic databases
PRIDE	Q3ISJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3702693.
GenomeReviews	Gene locus NP1592A in contig CR936257_GR.
KEGG	nph:NP1592A.
NMPDR	fig|348780.3.peg.165.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG06461.
HOGENOM	HBG731261.
OMA	GSYASEE.
PhylomeDB	Q3ISJ9.
ProtClustDB	PRK09293.
Enzyme and pathway databases
BioCyc	NPHA348780:NP1592A-MONOMER.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. IPR020548. Fructose_bisphosphatase_AS. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_NATPD

Accession

Primary (citable) accession number: Q3ISJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	November 8, 2005
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program