Q3IRQ2 (ILVC_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ketol-acid reductoisomerase
EC=1.1.1.86

Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase

Gene names

Name:	ilvC
Ordered Locus Names:	NP2198A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435 (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435
Sequence similarities	Belongs to the ketol-acid reductoisomerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro ketol-acid reductoisomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Ketol-acid reductoisomerase HAMAP MF_00435		PRO_0000226218
Sites
	Active site	109	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3IRQ2 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 9AC1D028799918D9	FASTA	331	35,966
	10 20 30 40 50 60 MTDATIYYDD DAESTVLDDK TVAVLGYGSQ GHAHAQNLDD SGVDVVVGLR EDSSSRSAAE 70 80 90 100 110 120 ADGLDVATPR GAAEQADLVS VLVPDTVQPA VYEQIEDVLQ PGDTLQFAHG FNIHYGQIEP 130 140 150 160 170 180 SEDVNVTMVA PKSPGHLVRR NYENDEGTPG LLAVYQDPSG EAHDLGLAYA KAIGCTRAGV 190 200 210 220 230 240 VETTFREETE TDLFGEQAVL CGGVTSLVKT GYETLVDAGY SPEMAYFECL NELKLIVDLM 250 260 270 280 290 300 YEGGNSEMWD SVSDTAEYGG LTRGDRIVDD HAREKMEEVL EEVQNGTFAR EWISENQAGR 310 320 330 PSYKQLRAAE KNHDIEAVGE DLRALFAWGD D

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI49190.1.
RefSeq	YP_326751.1. NC_007426.1.
3D structure databases
ProteinModelPortal	Q3IRQ2.
SMR	Q3IRQ2. Positions 5-328.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IRQ2.
Proteomic databases
PRIDE	Q3IRQ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3702867.
GenomeReviews	Gene locus NP2198A in contig CR936257_GR.
KEGG	nph:NP2198A.
NMPDR	fig|348780.3.peg.883.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04335.
HOGENOM	HBG286525.
OMA	MAYAKGI.
PhylomeDB	Q3IRQ2.
ProtClustDB	PRK05479.
Enzyme and pathway databases
BioCyc	NPHA348780:NP2198A-MONOMER.
Family and domain databases
HAMAP	MF_00435. IlvC. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013023. AcH_isomrdctse. IPR000506. AcH_isomrdctse_C. IPR013328. DH_multihelical. IPR013116. IlvN. [Graphical view]
Gene3D	G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00053.
PANTHER	PTHR21371. AcH_isomrdctse. 1 hit.
Pfam	PF01450. IlvC. 1 hit. PF07991. IlvN. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00465. IlvC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVC_NATPD

Accession

Primary (citable) accession number: Q3IRQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	November 8, 2005
Last modified:	November 16, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program