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Protein

NAD kinase

Gene

nadK

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei61Proton acceptorUniRule annotation1
Binding sitei144NADUniRule annotation1
Binding sitei163NADUniRule annotation1
Binding sitei165NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi61 – 62NADUniRule annotation2
Nucleotide bindingi133 – 134NADUniRule annotation2
Nucleotide bindingi176 – 181NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:NP_2512A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297201 – 270NAD kinaseAdd BLAST270

Proteomic databases

PRIDEiQ3IR96.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP2512A.

Structurei

3D structure databases

ProteinModelPortaliQ3IR96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348. Archaea.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiETFFAIN.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IR96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELGIVAKRE TPRAVELADR IRRHVDVPVT LDNLTADELD ANGTDVTSLS
60 70 80 90 100
ACDLVVSIGG DGTFLFAARE VSPTPVLGVN LGEVGFLNAV SPEECVETVA
110 120 130 140 150
GVVERMQAGD AELQELPQLQ ATGPGLSLPA AVNEVAVLGP QRGRDNGLDI
160 170 180 190 200
DVRVNGEGYS SGRADGVLVS TPTGSTAYNL SEGGPIVHPD VSAFVVTEMC
210 220 230 240 250
AESSMPSLAV PTDRTITVHV DGADHAVVAA DGRTRSQVAP PAEITLAVAA
260 270
DPVRIAGPKL EFFTALDKLD
Length:270
Mass (Da):27,955
Last modified:November 8, 2005 - v1
Checksum:iF4E07BED9F9C3E3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI49347.1.
RefSeqiWP_011322973.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI49347; CAI49347; NP_2512A.
GeneIDi3703046.
KEGGinph:NP_2512A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI49347.1.
RefSeqiWP_011322973.1. NC_007426.1.

3D structure databases

ProteinModelPortaliQ3IR96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi348780.NP2512A.

Proteomic databases

PRIDEiQ3IR96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI49347; CAI49347; NP_2512A.
GeneIDi3703046.
KEGGinph:NP_2512A.

Phylogenomic databases

eggNOGiarCOG01348. Archaea.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiETFFAIN.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_NATPD
AccessioniPrimary (citable) accession number: Q3IR96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.