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Q3IR96

- NADK_NATPD

UniProt

Q3IR96 - NADK_NATPD

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Protein
NAD kinase
Gene
nadK, NP_2512A
Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei61 – 611Proton acceptor By similarity
Binding sitei144 – 1441NAD By similarity
Binding sitei163 – 1631NAD By similarity
Binding sitei165 – 1651NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 622NAD By similarity
Nucleotide bindingi133 – 1342NAD By similarity
Nucleotide bindingi176 – 1816NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-1274-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:NP_2512A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
ProteomesiUP000002698: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270NAD kinaseUniRule annotation
PRO_0000229720Add
BLAST

Proteomic databases

PRIDEiQ3IR96.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP2512A.

Structurei

3D structure databases

ProteinModelPortaliQ3IR96.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiPRKTKFV.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IR96-1 [UniParc]FASTAAdd to Basket

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MELGIVAKRE TPRAVELADR IRRHVDVPVT LDNLTADELD ANGTDVTSLS    50
ACDLVVSIGG DGTFLFAARE VSPTPVLGVN LGEVGFLNAV SPEECVETVA 100
GVVERMQAGD AELQELPQLQ ATGPGLSLPA AVNEVAVLGP QRGRDNGLDI 150
DVRVNGEGYS SGRADGVLVS TPTGSTAYNL SEGGPIVHPD VSAFVVTEMC 200
AESSMPSLAV PTDRTITVHV DGADHAVVAA DGRTRSQVAP PAEITLAVAA 250
DPVRIAGPKL EFFTALDKLD 270
Length:270
Mass (Da):27,955
Last modified:November 8, 2005 - v1
Checksum:iF4E07BED9F9C3E3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49347.1.
RefSeqiWP_011322973.1. NC_007426.1.
YP_326907.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI49347; CAI49347; NP_2512A.
GeneIDi3703046.
KEGGinph:NP2512A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49347.1 .
RefSeqi WP_011322973.1. NC_007426.1.
YP_326907.1. NC_007426.1.

3D structure databases

ProteinModelPortali Q3IR96.
ModBasei Search...

Protein-protein interaction databases

STRINGi 348780.NP2512A.

Proteomic databases

PRIDEi Q3IR96.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI49347 ; CAI49347 ; NP_2512A .
GeneIDi 3703046.
KEGGi nph:NP2512A.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi PRKTKFV.

Enzyme and pathway databases

BioCyci NPHA348780:GJX0-1274-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiNADK_NATPD
AccessioniPrimary (citable) accession number: Q3IR96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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