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Protein

Catalase-peroxidase

Gene

katG

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei74 – 741Transition state stabilizerUniRule annotation
Active sitei78 – 781Proton acceptorUniRule annotation
Metal bindingi241 – 2411Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-1374-MONOMER.

Protein family/group databases

PeroxiBasei2515. NpCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:NP_2708A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 713713Catalase-peroxidasePRO_0000354970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki77 ↔ 200Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-226)UniRule annotation
Cross-linki200 ↔ 226Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-77)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiQ3IQZ9.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi348780.NP2708A.

Structurei

3D structure databases

ProteinModelPortaliQ3IQZ9.
SMRiQ3IQZ9. Positions 9-713.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04487. Archaea.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3IQZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDYKKLWP EALDFESLDQ NAQHVDPKDE DFDYAEAFQE LDLEEVKQDI
60 70 80 90 100
ESVMTDSQEW WPADYGHYGP LFIRMAWHSA GTYRTTDGRG GASGGYQRLP
110 120 130 140 150
PVDSWPDNAN LDKARRVLWP VKQKYGQNLS WADLIVLAGN VALESMGFET
160 170 180 190 200
FGFAGGREDD FAPDESVDWG PEEEMEASDR YDEAGELPEP LGATVMGLIY
210 220 230 240 250
VNPEGPDGEP DLEGSAANIR ESFGRMAMND EETVALIAGG HTFGKVHGAD
260 270 280 290 300
DPDEHVGGPP ADAPIDLQGL GWENDFGEGK GPDTITSGIE GPWNTTPTQW
310 320 330 340 350
DMSYIDNLLD YEWWPEKGPG GAWQWTTESG ELDAAAPSVD GSSEKEDVMM
360 370 380 390 400
LTTDVALKRD PDYREVLERF QENPDEFQEA FAKAWYKLIH RDMGPPERFL
410 420 430 440 450
GPEVPEETLI WQDPLPDADY DSIGDEEVAE LKEALLDSEL SVAQLVKTAW
460 470 480 490 500
ASASTYRDSD KRGGANGARI RLEPQRSWEV NEPAALADAL ETYEAIQEEF
510 520 530 540 550
NSARSDAVRV SLADLIVLGG NAAVEQAAAD AGYDVTVPFE PGRTDATPEQ
560 570 580 590 600
TDVESFEALK PKADGFRNYL SDEAERKPEE LLVDKADLLN LTPPEMTVLV
610 620 630 640 650
GGMRALGATY QDTDRGVFTD EPGTLTNDFF VNILDMDYEW EPVSEDREVF
660 670 680 690 700
ELRDRETGEV EWEGTRFDLI FGSDSRLRAI SEVYGADDGE AEFVEDFVDT
710
WSKVMKLDRF DLE
Length:713
Mass (Da):79,455
Last modified:November 8, 2005 - v1
Checksum:i90FA3F659414A865
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI49445.1.
RefSeqiWP_011323070.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI49445; CAI49445; NP_2708A.
GeneIDi3703016.
KEGGinph:NP_2708A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI49445.1.
RefSeqiWP_011323070.1. NC_007426.1.

3D structure databases

ProteinModelPortaliQ3IQZ9.
SMRiQ3IQZ9. Positions 9-713.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi348780.NP2708A.

Protein family/group databases

PeroxiBasei2515. NpCP01.

Proteomic databases

PRIDEiQ3IQZ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI49445; CAI49445; NP_2708A.
GeneIDi3703016.
KEGGinph:NP_2708A.

Phylogenomic databases

eggNOGiarCOG04487. Archaea.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiTESKCPF.

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-1374-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiKATG_NATPD
AccessioniPrimary (citable) accession number: Q3IQZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 8, 2005
Last modified: December 9, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.