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Q3IQW8

- Q3IQW8_NATPD

UniProt

Q3IQW8 - Q3IQW8_NATPD

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Protein

Ribulose bisphosphate carboxylase

Gene
rbcL, NP_2770A
Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the addition of molecular CO2 and H2O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase By similarity.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei153 – 1531Proton acceptor By similarityUniRule annotation
Binding sitei155 – 1551Substrate By similarityUniRule annotation
Metal bindingi179 – 1791Magnesium; via carbamate group By similarityUniRule annotation
Metal bindingi181 – 1811Magnesium By similarityUniRule annotation
Metal bindingi182 – 1821Magnesium By similarityUniRule annotation
Active sitei271 – 2711Proton acceptor By similarityUniRule annotation
Binding sitei272 – 2721Substrate By similarityUniRule annotation
Binding sitei304 – 3041Substrate By similarityUniRule annotation
Sitei312 – 3121Transition state stabilizer By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. ribulose-bisphosphate carboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbon fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, OxidoreductaseUniRule annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-1406-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylaseUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCOUniRule annotation
Gene namesi
Name:rbcLUniRule annotationImported
Ordered Locus Names:NP_2770AImported
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)Imported
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
ProteomesiUP000002698: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791N6-carboxylysine By similarityUniRule annotation

Proteomic databases

PRIDEiQ3IQW8.

Interactioni

Subunit structurei

Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi348780.NP2770A.

Structurei

3D structure databases

ProteinModelPortaliQ3IQW8.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 3423Substrate binding By similarityUniRule annotation
Regioni362 – 3654Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Belongs to the RuBisCO large chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1850.
HOGENOMiHOG000230831.
KOiK01601.
OMAiFTQDWAS.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProiIPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsiTIGR03326. rubisco_III. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IQW8-1 [UniParc]FASTAAdd to Basket

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MEYADFLDES YEPSDDDLVC TFRLVPGEGI SVADAAARVA SESSNGTWAA    50
LSPESDVRQY SALACDIGPE DEHGTQVTVA YPSGLFEDGS LPQILSCIAG 100
NIMGMKAVET IRLLDCEWPA VIARSFPGPQ YGSDVRTELL DAGDRPPLAT 150
VPKPKVGLST EEHVSVAESA WRGGVDLLKD DENLTDQTFN PFEQRVADSF 200
AARDRLEEET GERKDYLVNI TAETDEMVRR AEFVDDHGGS FVMVDIITCG 250
WSGLQTVRRR TEDLDLAIHA HRAMHAAFDR LPQHGVSMRC LAQFARLAGV 300
DHIHTGTAGL GKLENEDTAG INEWLRSDLH GHSDVLPVAS GGLHPGIVDQ 350
LLDALGTNVM VQAGGGIHGH PDGTEAGARA LRAAVDAYAD GESLDSRAES 400
VPALRTALDE WGTQNPR 417
Length:417
Mass (Da):44,911
Last modified:November 8, 2005 - v1
Checksum:i0DF3D4C18F33A6EC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49476.1.
RefSeqiYP_327035.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI49476; CAI49476; NP_2770A.
GeneIDi3703097.
KEGGinph:NP2770A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49476.1 .
RefSeqi YP_327035.1. NC_007426.1.

3D structure databases

ProteinModelPortali Q3IQW8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 348780.NP2770A.

Proteomic databases

PRIDEi Q3IQW8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI49476 ; CAI49476 ; NP_2770A .
GeneIDi 3703097.
KEGGi nph:NP2770A.

Phylogenomic databases

eggNOGi COG1850.
HOGENOMi HOG000230831.
KOi K01601.
OMAi FTQDWAS.

Enzyme and pathway databases

BioCyci NPHA348780:GJX0-1406-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
InterProi IPR017712. RuBisCO_III.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
TIGRFAMsi TIGR03326. rubisco_III. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiQ3IQW8_NATPD
AccessioniPrimary (citable) accession number: Q3IQW8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O2 to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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