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Q3IQR5

- HISX_NATPD

UniProt

Q3IQR5 - HISX_NATPD

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NADUniRule annotation
Binding sitei183 – 1831NADUniRule annotation
Binding sitei206 – 2061NADUniRule annotation
Binding sitei229 – 2291SubstrateUniRule annotation
Metal bindingi251 – 2511ZincUniRule annotation
Binding sitei251 – 2511SubstrateUniRule annotation
Metal bindingi254 – 2541ZincUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Active sitei320 – 3201Proton acceptorUniRule annotation
Active sitei321 – 3211Proton acceptorUniRule annotation
Binding sitei321 – 3211SubstrateUniRule annotation
Metal bindingi354 – 3541ZincUniRule annotation
Binding sitei354 – 3541SubstrateUniRule annotation
Binding sitei408 – 4081SubstrateUniRule annotation
Metal bindingi413 – 4131ZincUniRule annotation
Binding sitei413 – 4131SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-1461-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:NP_2876A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
ProteomesiUP000002698: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Histidinol dehydrogenasePRO_0000135900Add
BLAST

Proteomic databases

PRIDEiQ3IQR5.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP2876A.

Structurei

3D structure databases

ProteinModelPortaliQ3IQR5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3IQR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVSAVADLS PEARAALFER DAGIEDARES VRDIIGRVRE EGDVALRSYA
60 70 80 90 100
KEFDDVDIGT LAVTDEAERA YDDLDDDLRD AIETAAENIR TFHERQVPDD
110 120 130 140 150
WREQFDGREL GRRYRPLERV GVYAPGGTAA YPSSVLMGVI PAVVAGVDHV
160 170 180 190 200
AVATPPAEEL PAATLAAAHV AGADAVYQVG GAQAIAALAY GTESVSAVQK
210 220 230 240 250
VVGPGNRWVT AAKAEVRGDV EIDFLAGPSE LLVVCDDTAD PELIAADMVA
260 270 280 290 300
QAEHDPNASV VCVSDDEATA EAVADACERQ ATARERTEAI ESALENDASA
310 320 330 340 350
VLCARSMSEA VLFAEEYAAE HLSIVAADEE ALLDRIDSAG SVFLGGFSPV
360 370 380 390 400
AVGDYASGTN HVLPTGGLAK VAGGLSVDHF VRSTTVQKLD EDALSSLRET
410 420
VTTLARAEGL EAHAESVDKR FD
Length:422
Mass (Da):44,465
Last modified:November 8, 2005 - v1
Checksum:iEDC37AE445D0D7F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI49529.1.
RefSeqiWP_011323154.1. NC_007426.1.
YP_327088.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI49529; CAI49529; NP_2876A.
GeneIDi3702817.
KEGGinph:NP2876A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI49529.1 .
RefSeqi WP_011323154.1. NC_007426.1.
YP_327088.1. NC_007426.1.

3D structure databases

ProteinModelPortali Q3IQR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 348780.NP2876A.

Proteomic databases

PRIDEi Q3IQR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI49529 ; CAI49529 ; NP_2876A .
GeneIDi 3702817.
KEGGi nph:NP2876A.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci NPHA348780:GJX0-1461-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiHISX_NATPD
AccessioniPrimary (citable) accession number: Q3IQR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3