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Q3IQR5

- HISX_NATPD

UniProt

Q3IQR5 - HISX_NATPD

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Protein

Histidinol dehydrogenase

Gene
hisD, NP_2876A
Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei123 – 1231NAD By similarity
Binding sitei183 – 1831NAD By similarity
Binding sitei206 – 2061NAD By similarity
Binding sitei229 – 2291Substrate By similarity
Metal bindingi251 – 2511Zinc By similarity
Binding sitei251 – 2511Substrate By similarity
Metal bindingi254 – 2541Zinc By similarity
Binding sitei254 – 2541Substrate By similarity
Active sitei320 – 3201Proton acceptor By similarity
Active sitei321 – 3211Proton acceptor By similarity
Binding sitei321 – 3211Substrate By similarity
Metal bindingi354 – 3541Zinc By similarity
Binding sitei354 – 3541Substrate By similarity
Binding sitei408 – 4081Substrate By similarity
Metal bindingi413 – 4131Zinc By similarity
Binding sitei413 – 4131Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-1461-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:NP_2876A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
ProteomesiUP000002698: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Histidinol dehydrogenaseUniRule annotationPRO_0000135900Add
BLAST

Proteomic databases

PRIDEiQ3IQR5.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP2876A.

Structurei

3D structure databases

ProteinModelPortaliQ3IQR5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3IQR5-1 [UniParc]FASTAAdd to Basket

« Hide

MNVSAVADLS PEARAALFER DAGIEDARES VRDIIGRVRE EGDVALRSYA    50
KEFDDVDIGT LAVTDEAERA YDDLDDDLRD AIETAAENIR TFHERQVPDD 100
WREQFDGREL GRRYRPLERV GVYAPGGTAA YPSSVLMGVI PAVVAGVDHV 150
AVATPPAEEL PAATLAAAHV AGADAVYQVG GAQAIAALAY GTESVSAVQK 200
VVGPGNRWVT AAKAEVRGDV EIDFLAGPSE LLVVCDDTAD PELIAADMVA 250
QAEHDPNASV VCVSDDEATA EAVADACERQ ATARERTEAI ESALENDASA 300
VLCARSMSEA VLFAEEYAAE HLSIVAADEE ALLDRIDSAG SVFLGGFSPV 350
AVGDYASGTN HVLPTGGLAK VAGGLSVDHF VRSTTVQKLD EDALSSLRET 400
VTTLARAEGL EAHAESVDKR FD 422
Length:422
Mass (Da):44,465
Last modified:November 8, 2005 - v1
Checksum:iEDC37AE445D0D7F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49529.1.
RefSeqiWP_011323154.1. NC_007426.1.
YP_327088.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI49529; CAI49529; NP_2876A.
GeneIDi3702817.
KEGGinph:NP2876A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49529.1 .
RefSeqi WP_011323154.1. NC_007426.1.
YP_327088.1. NC_007426.1.

3D structure databases

ProteinModelPortali Q3IQR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 348780.NP2876A.

Proteomic databases

PRIDEi Q3IQR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI49529 ; CAI49529 ; NP_2876A .
GeneIDi 3702817.
KEGGi nph:NP2876A.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci NPHA348780:GJX0-1461-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiHISX_NATPD
AccessioniPrimary (citable) accession number: Q3IQR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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