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Q3IQR5

- HISX_NATPD

UniProt

Q3IQR5 - HISX_NATPD

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei123 – 1231NADUniRule annotation
    Binding sitei183 – 1831NADUniRule annotation
    Binding sitei206 – 2061NADUniRule annotation
    Binding sitei229 – 2291SubstrateUniRule annotation
    Metal bindingi251 – 2511ZincUniRule annotation
    Binding sitei251 – 2511SubstrateUniRule annotation
    Metal bindingi254 – 2541ZincUniRule annotation
    Binding sitei254 – 2541SubstrateUniRule annotation
    Active sitei320 – 3201Proton acceptorUniRule annotation
    Active sitei321 – 3211Proton acceptorUniRule annotation
    Binding sitei321 – 3211SubstrateUniRule annotation
    Metal bindingi354 – 3541ZincUniRule annotation
    Binding sitei354 – 3541SubstrateUniRule annotation
    Binding sitei408 – 4081SubstrateUniRule annotation
    Metal bindingi413 – 4131ZincUniRule annotation
    Binding sitei413 – 4131SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciNPHA348780:GJX0-1461-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:NP_2876A
    OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
    Taxonomic identifieri348780 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
    ProteomesiUP000002698: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Histidinol dehydrogenasePRO_0000135900Add
    BLAST

    Proteomic databases

    PRIDEiQ3IQR5.

    Interactioni

    Protein-protein interaction databases

    STRINGi348780.NP2876A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IQR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiYAAKLCG.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3IQR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVSAVADLS PEARAALFER DAGIEDARES VRDIIGRVRE EGDVALRSYA    50
    KEFDDVDIGT LAVTDEAERA YDDLDDDLRD AIETAAENIR TFHERQVPDD 100
    WREQFDGREL GRRYRPLERV GVYAPGGTAA YPSSVLMGVI PAVVAGVDHV 150
    AVATPPAEEL PAATLAAAHV AGADAVYQVG GAQAIAALAY GTESVSAVQK 200
    VVGPGNRWVT AAKAEVRGDV EIDFLAGPSE LLVVCDDTAD PELIAADMVA 250
    QAEHDPNASV VCVSDDEATA EAVADACERQ ATARERTEAI ESALENDASA 300
    VLCARSMSEA VLFAEEYAAE HLSIVAADEE ALLDRIDSAG SVFLGGFSPV 350
    AVGDYASGTN HVLPTGGLAK VAGGLSVDHF VRSTTVQKLD EDALSSLRET 400
    VTTLARAEGL EAHAESVDKR FD 422
    Length:422
    Mass (Da):44,465
    Last modified:November 8, 2005 - v1
    Checksum:iEDC37AE445D0D7F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936257 Genomic DNA. Translation: CAI49529.1.
    RefSeqiWP_011323154.1. NC_007426.1.
    YP_327088.1. NC_007426.1.

    Genome annotation databases

    EnsemblBacteriaiCAI49529; CAI49529; NP_2876A.
    GeneIDi3702817.
    KEGGinph:NP2876A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936257 Genomic DNA. Translation: CAI49529.1 .
    RefSeqi WP_011323154.1. NC_007426.1.
    YP_327088.1. NC_007426.1.

    3D structure databases

    ProteinModelPortali Q3IQR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 348780.NP2876A.

    Proteomic databases

    PRIDEi Q3IQR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI49529 ; CAI49529 ; NP_2876A .
    GeneIDi 3702817.
    KEGGi nph:NP2876A.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi YAAKLCG.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci NPHA348780:GJX0-1461-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
      Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
      Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35678 / DSM 2160.

    Entry informationi

    Entry nameiHISX_NATPD
    AccessioniPrimary (citable) accession number: Q3IQR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3