Q3IQG6 (AROA_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	NP3078A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	438 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 438	438	Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000071738

Sequences

	Sequence		Length	Mass (Da)
	Q3IQG6 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 21E5FC32FF60BEE8	FASTA	438	44,955
	10 20 30 40 50 60 MDAHITPSTV NGTVRAPPSK SYTHRAILAA GYGDGATVKN PLFSADTRAT ARAVEAYGGT 70 80 90 100 110 120 TEQADDDLEV TGFDGTPGTP KDVINCANSG TTMRLTTATG ALVDGLAVLT GDESLRSRPQ 130 140 150 160 170 180 GPLLDALDQL GARAESTREN GQAPLVVGGD IDGGELAIRG DVSSQYITGL LMAGAVTESG 190 200 210 220 230 240 IDIELTTALK SAPYVDITLE VLADFGVDAE VIGGDDSEVR SAGADGFRVD GGQSYAPTDG 250 260 270 280 290 300 TYHVPGDFSS MSYLLAAGAL AADEEVVVAG AHPSAQGDAA IVSILESMGA DIEWNRDDGR 310 320 330 340 350 360 ITVRQSSLSG VEVGVADTPD LLPTIAVLGA AADGETRITD CEHVRLKETD RVAAMATELE 370 380 390 400 410 420 RLGVETDEYE DELVVYGGGI DGGTVAGHDD HRIVMSLAVA GLVADGEVTI KNADHVDVSF 430 PSFFETLADL GVGVETGA

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI49630.1.
RefSeq	YP_327187.1. NC_007426.1.
3D structure databases
HSSP	HSSP built from PDB template 2AA9 based on UniProtKB P0A6D3.
ProteinModelPortal	Q3IQG6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IQG6.
Proteomic databases
PRIDE	Q3IQG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3702526.
GenomeReviews	Gene locus NP3078A in contig CR936257_GR.
KEGG	nph:NP3078A.
NMPDR	fig|348780.3.peg.1524.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05032.
HOGENOM	HBG646626.
OMA	RLRIKEC.
PhylomeDB	Q3IQG6.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	NPHA348780:NP3078A-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_NATPD

Accession

Primary (citable) accession number: Q3IQG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	November 8, 2005
Last modified:	November 16, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program