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Protein

Proteasome subunit beta

Gene

psmB

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

BioCyciNPHA348780:G1GI2-1726-MONOMER

Protein family/group databases

MEROPSiT01.002

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit betaUniRule annotation (EC:3.4.25.1UniRule annotation)
Alternative name(s):
20S proteasome beta subunitUniRule annotation
Proteasome core protein PsmBUniRule annotation
Gene namesi
Name:psmBUniRule annotation
Ordered Locus Names:NP_3472A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00003973841 – 44Removed in mature form; by autocatalysisUniRule annotationAdd BLAST44
ChainiPRO_000039738545 – 239Proteasome subunit betaAdd BLAST195

Keywords - PTMi

Autocatalytic cleavage, Zymogen

Proteomic databases

PRIDEiQ3IPX1

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGi348780.NP3472A

Structurei

3D structure databases

ProteinModelPortaliQ3IPX1
SMRiQ3IPX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00970 Archaea
COG0638 LUCA
HOGENOMiHOG000091083
KOiK03433
OMAiDLCVIRK
OrthoDBiPOG093Z0CM8

Family and domain databases

Gene3Di3.60.20.10, 1 hit
HAMAPiMF_02113_A Proteasome_B_A, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR019983 Pept_T1A_Psome_bsu_arc
IPR000243 Pept_T1A_subB
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PRINTSiPR00141 PROTEASOME
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR03634 arc_protsome_B, 1 hit
PROSITEiView protein in PROSITE
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3IPX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQPDSSLPR TGQDHTLSPY EPELGEVPSN DLSMADLDNV NKTGTTTIGI
60 70 80 90 100
STAEGVVIAT DMRASLGGRF VSNKNVQKVE QIHPSAALTL VGSVGGAQSF
110 120 130 140 150
IRSLRAEVDL YEARRGEDIS INALATLAGN FARGGPFFAI NPILGGVDDE
160 170 180 190 200
GHHVYSIDPA GGVMKDDYTV TGSGLTVAYG TLEREYEDDM TNEEAKRVAA
210 220 230
SGIKAAVERD TGSGNGVFLA TVTDEDVEIK GHKDFDEVL
Length:239
Mass (Da):25,318
Last modified:November 8, 2005 - v1
Checksum:i66FDAE4F09F47A16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA Translation: CAI49827.1
RefSeqiWP_011323447.1, NC_007426.1

Genome annotation databases

GeneIDi3703062
KEGGinph:NP_3472A

Similar proteinsi

Entry informationi

Entry nameiPSB_NATPD
AccessioniPrimary (citable) accession number: Q3IPX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health