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Q3IPL2

- SYE_NATPD

UniProt

Q3IPL2 - SYE_NATPD

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Protein
Glutamate--tRNA ligase
Gene
gltX, NP_3694A
Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-1874-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:gltX
Ordered Locus Names:NP_3694A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
ProteomesiUP000002698: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Glutamate--tRNA ligaseUniRule annotation
PRO_0000237425Add
BLAST

Proteomic databases

PRIDEiQ3IPL2.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP3694A.

Structurei

3D structure databases

ProteinModelPortaliQ3IPL2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 12411"HIGH" regionUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000073585.
KOiK01885.
OMAiYLGWDDP.

Family and domain databases

Gene3Di1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_A. Glu_tRNA_synth_A.
InterProiIPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF50715. SSF50715. 1 hit.
TIGRFAMsiTIGR00463. gltX_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IPL2-1 [UniParc]FASTAAdd to Basket

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MDEDLRERIE REAETAALFN ALKHESDAQV GAILGPMMGE NPDFRPHGDE    50
IPGIISPVIE RVNGLSDEEK RERLEELAPE KVEALAAEDE GDDRPLPELP 100
NADAYDDVRM RLAPNPNGPW HVGHARMPAV IGTYKDRYDG WFCVRFDDTD 150
PETKRPDLDA YGEILDAIDY LGFEPDEVVK ASDRVETYYE YGRKLIKAGG 200
AYTCSCDAES FSELKNNAEA CPHRDKDIET TLSEFEAMID GEYSAGEMVL 250
RVRTDIEHKN PALRDWVAFR MVDTPHPREE AADYRCWPML DFQSGIDDHE 300
FGISHIIRGI DLQDSAKRQQ FVYEYFDWEY PEVIHWGHVQ IDAYDIEMST 350
STIKQLIDDG ELDDWDDPRA PTVASLKRRG IRGQAIVNAM VELGTSTSNV 400
DLAMSSVYAE NREFVDDEAD RRFFVRDGVE KPLAGGPESA SPPLHPNDED 450
RGRREIPVGD AVYVEPDDVP ADGERVWLKG LGPVRHEDGA FVATDDDIEV 500
VRDGAVDVVH WVPAQESVPL RLRTVDGDEA GHAEPGIETY DADDIVQFER 550
IGFARIDRHD DEESVAYFAH P 571
Length:571
Mass (Da):64,418
Last modified:November 8, 2005 - v1
Checksum:i80D88F8AB47E9D12
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49938.1.
RefSeqiWP_011323556.1. NC_007426.1.
YP_327491.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI49938; CAI49938; NP_3694A.
GeneIDi3702761.
KEGGinph:NP3694A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI49938.1 .
RefSeqi WP_011323556.1. NC_007426.1.
YP_327491.1. NC_007426.1.

3D structure databases

ProteinModelPortali Q3IPL2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 348780.NP3694A.

Proteomic databases

PRIDEi Q3IPL2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI49938 ; CAI49938 ; NP_3694A .
GeneIDi 3702761.
KEGGi nph:NP3694A.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000073585.
KOi K01885.
OMAi YLGWDDP.

Enzyme and pathway databases

BioCyci NPHA348780:GJX0-1874-MONOMER.

Family and domain databases

Gene3Di 1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_A. Glu_tRNA_synth_A.
InterProi IPR004526. Glu-tRNA-synth_arc/euk.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR020059. Glu/Gln-tRNA-synth_Ib_codon-bd.
IPR022888. Glu_tRNA_synth_arc.
IPR011035. Ribosomal_L25/Gln-tRNA_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
PF03950. tRNA-synt_1c_C. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF50715. SSF50715. 1 hit.
TIGRFAMsi TIGR00463. gltX_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiSYE_NATPD
AccessioniPrimary (citable) accession number: Q3IPL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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