Q3IP82 (TYPH_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

NP_3958A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas › Natronomonas pharaonis

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000314731

Sequences

	Sequence		Length	Mass (Da)
	Q3IP82 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 7E1341E905A7E241	FASTA	500	52,699
	10 20 30 40 50 60 MELTVEPIDI GTERPVVLLN CADAETLGVH SLDRVEIDWD GTTEVGIVKV TDELVAAGRI 70 80 90 100 110 120 GASHGFPEIT DGTVVAVTPA GQPESVESIR RKLDGRELDS DELGAIVADI EADRLSDLEL 130 140 150 160 170 180 SAYVCASHAN GLSLEETKQL TERMAEVGKQ LSWEQPVVAD KHSIGGVAGN RVTPVVVAIV 190 200 210 220 230 240 AAAGLTIPKT SSRAVTSPAG TADTMEVFCP VEFSREEIRD IVTETGGCLV WGGAVDLSPV 250 260 270 280 290 300 DDKVIRAQRP LSLDPPGQVI ASVLSKKQSA GSSHIVVDIP YGAGAKVTSL SEARDLADDF 310 320 330 340 350 360 RRVGDHLGLT IECALTRGSD PIGHGIGPVL EARDVLAVLE GEGPEPLRIK SLRLADIIFD 370 380 390 400 410 420 MAREAGMPVD DRSAADILDS GAALSKFRDI VAVQGGDPDV SRDDLQPGDR TETVTADTDG 430 440 450 460 470 480 LVVDVDNQAV SQLARRAGAP NDHGAGVVIH RRTGDKAVAG DVLYTIHAES SDRLEAAREY 490 500 AAGDEIVRVG GRDEALVERR

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI50070.1.
RefSeq	YP_327621.1. NC_007426.1.
3D structure databases
ProteinModelPortal	Q3IP82.
ModBase	Search...
Protein-protein interaction databases
STRING	348780.NP3958A.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI50070; CAI50070; NP_3958A.
GeneID	3702662.
KEGG	nph:NP3958A.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	NPHA348780:GJX0-2009-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_NATPD

Accession

Primary (citable) accession number: Q3IP82

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program