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Protein

AMP phosphorylase

Gene

deoA

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166AMP; via amide nitrogenUniRule annotation1
Binding sitei201AMP; via amide nitrogenUniRule annotation1
Active sitei254Proton donorUniRule annotation1
Binding sitei262AMPUniRule annotation1
Binding sitei286AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi192 – 197AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciNPHA348780:G1GI2-1970-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Name:deoA
Ordered Locus Names:NP_3958A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147311 – 500AMP phosphorylaseAdd BLAST500

Proteomic databases

PRIDEiQ3IP82

Interactioni

Protein-protein interaction databases

STRINGi348780.NP3958A

Structurei

3D structure databases

ProteinModelPortaliQ3IP82
SMRiQ3IP82
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q3IP82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELTVEPIDI GTERPVVLLN CADAETLGVH SLDRVEIDWD GTTEVGIVKV
60 70 80 90 100
TDELVAAGRI GASHGFPEIT DGTVVAVTPA GQPESVESIR RKLDGRELDS
110 120 130 140 150
DELGAIVADI EADRLSDLEL SAYVCASHAN GLSLEETKQL TERMAEVGKQ
160 170 180 190 200
LSWEQPVVAD KHSIGGVAGN RVTPVVVAIV AAAGLTIPKT SSRAVTSPAG
210 220 230 240 250
TADTMEVFCP VEFSREEIRD IVTETGGCLV WGGAVDLSPV DDKVIRAQRP
260 270 280 290 300
LSLDPPGQVI ASVLSKKQSA GSSHIVVDIP YGAGAKVTSL SEARDLADDF
310 320 330 340 350
RRVGDHLGLT IECALTRGSD PIGHGIGPVL EARDVLAVLE GEGPEPLRIK
360 370 380 390 400
SLRLADIIFD MAREAGMPVD DRSAADILDS GAALSKFRDI VAVQGGDPDV
410 420 430 440 450
SRDDLQPGDR TETVTADTDG LVVDVDNQAV SQLARRAGAP NDHGAGVVIH
460 470 480 490 500
RRTGDKAVAG DVLYTIHAES SDRLEAAREY AAGDEIVRVG GRDEALVERR
Length:500
Mass (Da):52,699
Last modified:November 8, 2005 - v1
Checksum:i7E1341E905A7E241
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA Translation: CAI50070.1
RefSeqiWP_011323686.1, NC_007426.1

Genome annotation databases

EnsemblBacteriaiCAI50070; CAI50070; NP_3958A
GeneIDi3702662
KEGGinph:NP_3958A

Similar proteinsi

Entry informationi

Entry nameiAMPPA_NATPD
AccessioniPrimary (citable) accession number: Q3IP82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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