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Q3IP82

- AMPPA_NATPD

UniProt

Q3IP82 - AMPPA_NATPD

Protein

AMP phosphorylase

Gene

NP_3958A

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

    Catalytic activityi

    AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
    UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei166 – 1661AMP; via amide nitrogenUniRule annotation
    Binding sitei201 – 2011AMP; via amide nitrogenUniRule annotation
    Active sitei254 – 2541Proton donorUniRule annotation
    Binding sitei262 – 2621AMPUniRule annotation
    Binding sitei286 – 2861AMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi192 – 1976AMPUniRule annotation

    GO - Molecular functioni

    1. AMP binding Source: UniProtKB-HAMAP
    2. phosphorylase activity Source: InterPro
    3. thymidine phosphorylase activity Source: InterPro

    GO - Biological processi

    1. AMP catabolic process Source: UniProtKB-HAMAP
    2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
    3. pyrimidine nucleobase metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciNPHA348780:GJX0-2009-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
    Short name:
    AMPpaseUniRule annotation
    Alternative name(s):
    Nucleoside monophosphate phosphorylaseUniRule annotation
    Short name:
    NMP phosphorylaseUniRule annotation
    Gene namesi
    Ordered Locus Names:NP_3958A
    OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
    Taxonomic identifieri348780 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
    ProteomesiUP000002698: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500AMP phosphorylasePRO_0000314731Add
    BLAST

    Proteomic databases

    PRIDEiQ3IP82.

    Interactioni

    Protein-protein interaction databases

    STRINGi348780.NP3958A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IP82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0213.
    HOGENOMiHOG000252767.
    KOiK00758.
    OMAiFINGVRD.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPiMF_02132. AMP_phosphorylase.
    InterProiIPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000478. TP_PyNP. 1 hit.
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3IP82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELTVEPIDI GTERPVVLLN CADAETLGVH SLDRVEIDWD GTTEVGIVKV    50
    TDELVAAGRI GASHGFPEIT DGTVVAVTPA GQPESVESIR RKLDGRELDS 100
    DELGAIVADI EADRLSDLEL SAYVCASHAN GLSLEETKQL TERMAEVGKQ 150
    LSWEQPVVAD KHSIGGVAGN RVTPVVVAIV AAAGLTIPKT SSRAVTSPAG 200
    TADTMEVFCP VEFSREEIRD IVTETGGCLV WGGAVDLSPV DDKVIRAQRP 250
    LSLDPPGQVI ASVLSKKQSA GSSHIVVDIP YGAGAKVTSL SEARDLADDF 300
    RRVGDHLGLT IECALTRGSD PIGHGIGPVL EARDVLAVLE GEGPEPLRIK 350
    SLRLADIIFD MAREAGMPVD DRSAADILDS GAALSKFRDI VAVQGGDPDV 400
    SRDDLQPGDR TETVTADTDG LVVDVDNQAV SQLARRAGAP NDHGAGVVIH 450
    RRTGDKAVAG DVLYTIHAES SDRLEAAREY AAGDEIVRVG GRDEALVERR 500
    Length:500
    Mass (Da):52,699
    Last modified:November 8, 2005 - v1
    Checksum:i7E1341E905A7E241
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936257 Genomic DNA. Translation: CAI50070.1.
    RefSeqiYP_327621.1. NC_007426.1.

    Genome annotation databases

    EnsemblBacteriaiCAI50070; CAI50070; NP_3958A.
    GeneIDi3702662.
    KEGGinph:NP3958A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936257 Genomic DNA. Translation: CAI50070.1 .
    RefSeqi YP_327621.1. NC_007426.1.

    3D structure databases

    ProteinModelPortali Q3IP82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 348780.NP3958A.

    Proteomic databases

    PRIDEi Q3IP82.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI50070 ; CAI50070 ; NP_3958A .
    GeneIDi 3702662.
    KEGGi nph:NP3958A.

    Phylogenomic databases

    eggNOGi COG0213.
    HOGENOMi HOG000252767.
    KOi K00758.
    OMAi FINGVRD.

    Enzyme and pathway databases

    BioCyci NPHA348780:GJX0-2009-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    HAMAPi MF_02132. AMP_phosphorylase.
    InterProi IPR017713. AMP_phosphorylase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    IPR017872. Pyrmidine_PPase_CS.
    IPR013466. Thymidine/AMP_Pase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000478. TP_PyNP. 1 hit.
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
    TIGR02645. ARCH_P_rylase. 1 hit.
    PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
      Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
      Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35678 / DSM 2160.

    Entry informationi

    Entry nameiAMPPA_NATPD
    AccessioniPrimary (citable) accession number: Q3IP82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3