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Q3IP73

- PROB_NATPD

UniProt

Q3IP73 - PROB_NATPD

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Protein
Glutamate 5-kinase
Gene
proB, NP_3976A
Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATP By similarity
Binding sitei73 – 731Substrate By similarity
Binding sitei158 – 1581Substrate By similarity
Binding sitei170 – 1701Substrate; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi190 – 1912ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate 5-kinase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-2018-MONOMER.
UniPathwayiUPA00098; UER00359.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinase (EC:2.7.2.11)
Alternative name(s):
Gamma-glutamyl kinase
Short name:
GK
Gene namesi
Name:proB
Ordered Locus Names:NP_3976A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
ProteomesiUP000002698: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Glutamate 5-kinaseUniRule annotation
PRO_0000230077Add
BLAST

Proteomic databases

PRIDEiQ3IP73.

Interactioni

Protein-protein interaction databases

STRINGi348780.NP3976A.

Structurei

3D structure databases

ProteinModelPortaliQ3IP73.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0263.
HOGENOMiHOG000246368.
KOiK00931.
OMAiDIHYRQA.

Family and domain databases

Gene3Di3.40.1160.10. 1 hit.
HAMAPiMF_00456. ProB.
InterProiIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000729. GK. 1 hit.
PRINTSiPR00474. GLU5KINASE.
SUPFAMiSSF53633. SSF53633. 1 hit.
TIGRFAMsiTIGR01027. proB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IP73-1 [UniParc]FASTAAdd to Basket

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MSETIADELG SVPQSVVEAA REDAANAKRV VVKAGTNSLT DEESNLDDDK    50
LDKLVDDIAD LLERDKDVLL VSSGAVGAGI GRVGYGSRTV EESQALSTVG 100
QSHLMRRYTE SFERYDRKVA QILLTQQDLE NPERFTNFCN TVETLLEWDI 150
VPIINENDAV ATQEIRIGDN DMLSSSVAVG VDADLLVTLT DVDAVYTGNP 200
KEDPDAERIE AVGENYDQIQ GLVEESSSSD FGGIRTKVEG ARNVSEYGIP 250
AIIAGSAEPD VLQQIATGKS VGTLFVPING ETDD 284
Length:284
Mass (Da):30,584
Last modified:November 8, 2005 - v1
Checksum:i8E755E552D667BB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI50079.2.
RefSeqiYP_327630.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI50079; CAI50079; NP_3976A.
GeneIDi3703055.
KEGGinph:NP3976A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR936257 Genomic DNA. Translation: CAI50079.2 .
RefSeqi YP_327630.1. NC_007426.1.

3D structure databases

ProteinModelPortali Q3IP73.
ModBasei Search...

Protein-protein interaction databases

STRINGi 348780.NP3976A.

Proteomic databases

PRIDEi Q3IP73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI50079 ; CAI50079 ; NP_3976A .
GeneIDi 3703055.
KEGGi nph:NP3976A.

Phylogenomic databases

eggNOGi COG0263.
HOGENOMi HOG000246368.
KOi K00931.
OMAi DIHYRQA.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00359 .
BioCyci NPHA348780:GJX0-2018-MONOMER.

Family and domain databases

Gene3Di 3.40.1160.10. 1 hit.
HAMAPi MF_00456. ProB.
InterProi IPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
[Graphical view ]
Pfami PF00696. AA_kinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000729. GK. 1 hit.
PRINTSi PR00474. GLU5KINASE.
SUPFAMi SSF53633. SSF53633. 1 hit.
TIGRFAMsi TIGR01027. proB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiPROB_NATPD
AccessioniPrimary (citable) accession number: Q3IP73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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