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Q3IP73

- PROB_NATPD

UniProt

Q3IP73 - PROB_NATPD

Protein

Glutamate 5-kinase

Gene

proB

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPUniRule annotation
    Binding sitei73 – 731SubstrateUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation
    Binding sitei170 – 1701Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi190 – 1912ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNPHA348780:GJX0-2018-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:NP_3976A
    OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
    Taxonomic identifieri348780 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
    ProteomesiUP000002698: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Glutamate 5-kinasePRO_0000230077Add
    BLAST

    Proteomic databases

    PRIDEiQ3IP73.

    Interactioni

    Protein-protein interaction databases

    STRINGi348780.NP3976A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IP73.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiDIHYRQA.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3IP73-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSETIADELG SVPQSVVEAA REDAANAKRV VVKAGTNSLT DEESNLDDDK    50
    LDKLVDDIAD LLERDKDVLL VSSGAVGAGI GRVGYGSRTV EESQALSTVG 100
    QSHLMRRYTE SFERYDRKVA QILLTQQDLE NPERFTNFCN TVETLLEWDI 150
    VPIINENDAV ATQEIRIGDN DMLSSSVAVG VDADLLVTLT DVDAVYTGNP 200
    KEDPDAERIE AVGENYDQIQ GLVEESSSSD FGGIRTKVEG ARNVSEYGIP 250
    AIIAGSAEPD VLQQIATGKS VGTLFVPING ETDD 284
    Length:284
    Mass (Da):30,584
    Last modified:November 8, 2005 - v1
    Checksum:i8E755E552D667BB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936257 Genomic DNA. Translation: CAI50079.2.
    RefSeqiYP_327630.1. NC_007426.1.

    Genome annotation databases

    EnsemblBacteriaiCAI50079; CAI50079; NP_3976A.
    GeneIDi3703055.
    KEGGinph:NP3976A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR936257 Genomic DNA. Translation: CAI50079.2 .
    RefSeqi YP_327630.1. NC_007426.1.

    3D structure databases

    ProteinModelPortali Q3IP73.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 348780.NP3976A.

    Proteomic databases

    PRIDEi Q3IP73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI50079 ; CAI50079 ; NP_3976A .
    GeneIDi 3703055.
    KEGGi nph:NP3976A.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi DIHYRQA.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci NPHA348780:GJX0-2018-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
      Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
      Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35678 / DSM 2160.

    Entry informationi

    Entry nameiPROB_NATPD
    AccessioniPrimary (citable) accession number: Q3IP73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3