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Q3IP35 (THIM_NATPD) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:NP_4052A
OrganismNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis) [Complete proteome] [HAMAP]
Taxonomic identifier348780 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383922

Sites

Binding site491Substrate; via amide nitrogen By similarity
Binding site1251ATP By similarity
Binding site1711ATP By similarity
Binding site1981Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q3IP35 [UniParc].

Last modified November 8, 2005. Version 1.
Checksum: A3923D1647630C7C

FASTA27828,228
        10         20         30         40         50         60 
MSDVDAAVDL AAALGDIDTA TPLVNSVTNN VTVNDVANIT LHWGGLPVMS DDAREVDDMV 

        70         80         90        100        110        120 
ATADGCLINM GTVDEDGEES MVVAGTAANE GDKPLVVDPV GVGATPTRTR VANRLLDELD 

       130        140        150        160        170        180 
VTILNGNHGE ITALAGDDAD VRGVESVGEY ADIAETALSC ARTHDTVVVA SGETDIVASP 

       190        200        210        220        230        240 
EEAYEITAGH PLMAQIVGTG CMLGVTLATF AAGMENATPL DAALAGTVGF GLAGEKAAEE 

       250        260        270 
GEYNGPASYK TAFLDTVAGL EAAPDDPAGR IERVLSVT 

« Hide

References

[1]"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35678 / DSM 2160.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR936257 Genomic DNA. Translation: CAI50117.1.
RefSeqYP_330755.1. NC_007426.1.

3D structure databases

ProteinModelPortalQ3IP35.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING348780.NP4052A.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI50117; CAI50117; NP_4052A.
GeneID3703251.
KEGGnph:NP4052A.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.

Enzyme and pathway databases

BioCycNPHA348780:GJX0-2057-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_NATPD
AccessionPrimary (citable) accession number: Q3IP35
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 8, 2005
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways