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Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

NP_4470A

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciNPHA348780:GJX0-2268-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.42UniRule annotation)
Short name:
DGGGP synthaseUniRule annotation
Short name:
DGGGPSUniRule annotation
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Geranylgeranylglycerol-phosphate geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:NP_4470A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalUniRule annotationAdd
BLAST
Transmembranei40 – 6021HelicalUniRule annotationAdd
BLAST
Transmembranei89 – 10921HelicalUniRule annotationAdd
BLAST
Transmembranei143 – 16321HelicalUniRule annotationAdd
BLAST
Transmembranei199 – 21921HelicalUniRule annotationAdd
BLAST
Transmembranei220 – 24021HelicalUniRule annotationAdd
BLAST
Transmembranei256 – 27621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 277277Digeranylgeranylglyceryl phosphate synthasePRO_0000350714Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi348780.NP4470A.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiNCITASF.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3INH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERVRGLVEL LRPGNAVAAG GLTFIGAFVA GGLSSPQSMA FAVVATVLAT
60 70 80 90 100
GAGNAINDYF DRDIDAINEP DRPIPRGAVS PRGALVYSVA LFAVAVVLTL
110 120 130 140 150
LLPWLAIAIA AINLVALVAY TEVFKGLPGV GNALVAYLTG STFLYGGAAV
160 170 180 190 200
GGDLAAVVVL FALAACATMA REIVKDVEDI DGDRAEGLRT LPIVIGERRS
210 220 230 240 250
LYVAAGFVVV AVLSSPLPYL LGLFGWVYLV VLVPALCGLA AATWRSFSDP
260 270
TTGQAWLKAS MFAAAVAFVI GRLAVVA
Length:277
Mass (Da):28,508
Last modified:November 8, 2005 - v1
Checksum:i4097BBBE8CBCE568
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI50326.1.
RefSeqiWP_011323941.1. NC_007426.1.

Genome annotation databases

EnsemblBacteriaiCAI50326; CAI50326; NP_4470A.
GeneIDi3703434.
KEGGinph:NP_4470A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA. Translation: CAI50326.1.
RefSeqiWP_011323941.1. NC_007426.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi348780.NP4470A.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI50326; CAI50326; NP_4470A.
GeneIDi3703434.
KEGGinph:NP_4470A.

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiNCITASF.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciNPHA348780:GJX0-2268-MONOMER.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis."
    Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D.
    Genome Res. 15:1336-1343(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35678 / DSM 2160.

Entry informationi

Entry nameiDGGGP_NATPD
AccessioniPrimary (citable) accession number: Q3INH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: November 8, 2005
Last modified: November 11, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.