Q3INF0 (KHSE_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	NP4524A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Homoserine kinase HAMAP MF_00384		PRO_1000049153
Regions
	Nucleotide binding	80 – 90	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3INF0 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 8F11B745057EE066	FASTA	291	29,485
	10 20 30 40 50 60 MITVRAPATS ANLGSGFDVF GAALERPADI LRIEKANRTT IRVTGVGSKY IPEDPEKNTV 70 80 90 100 110 120 GAVAEALDAP AHIEIDKGVR PASGLGSSAA SAAAAAVGLN ELYDRGLSRE ELVPIAAEGE 130 140 150 160 170 180 AVVSGAAHAD NVAPSIMGGF TVAREDGVTQ VDASIPLVAC LPEIVVSTRD ARGVVPEAAP 190 200 210 220 230 240 MEAVVDVVGN AATLAVGMAR DDPALVGRGM EDSIVTPERA ELINGYETVR SAAENAGATG 250 260 270 280 290 VTISGAGPTV IAACHRGDRT AIASAMLDAF SEAGVEARAY KTEIGRGAEL F

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI50353.1.
RefSeq	YP_330990.1. NC_007426.1.
3D structure databases
HSSP	HSSP built from PDB template 1H72 based on UniProtKB Q58504.
ProteinModelPortal	Q3INF0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3INF0.
Proteomic databases
PRIDE	Q3INF0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3703252.
GenomeReviews	Gene locus NP4524A in contig CR936257_GR.
KEGG	nph:NP4524A.
NMPDR	fig|348780.3.peg.2399.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05905.
HOGENOM	HBG646290.
OMA	GSAHADN.
PhylomeDB	Q3INF0.
ProtClustDB	PRK01212.
Enzyme and pathway databases
BioCyc	NPHA348780:NP4524A-MONOMER.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_NATPD

Accession

Primary (citable) accession number: Q3INF0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	November 16, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program