Q3IN28 (GCST_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	NP4774A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Probable aminomethyltransferase HAMAP MF_00259		PRO_1000047681

Sequences

	Sequence		Length	Mass (Da)
	Q3IN28 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 0BB8413B93E05142	FASTA	358	38,159
	10 20 30 40 50 60 MSLRTPPLFD AHTDAGAKLT EFGGWEMPVE FDSIRTEHDA VRESAGKFDI SHMGEIEVSG 70 80 90 100 110 120 PDAAALTNRL TTNDVASLAP GEATYAGITD DDGVLLDDTV VYRLPDGATY LFVPNAGNDE 130 140 150 160 170 180 LMAERWRSFA DRWDLAATVD NATDDYAMVA LQGPDALELL SSLDVDVFDL SRFEAAERTV 190 200 210 220 230 240 AGVDCLVSRT GYTGEDGVEL LFETAAAETV WSALDCQPCG LGARDTLRLE AGFLLGGNEF 250 260 270 280 290 300 DPETNPRTPY EANIGFAVDL GTEFVGSDAL AAQREAGPDE RLVGLRLQDR GIARHGHDIV 310 320 330 340 350 AAGDVVGEVT SGTMSPTLGA AIALGYVPVE YTEPGTELAV VVRGDEKDAV VEALPFYE

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI50478.1.
RefSeq	YP_331112.1. NC_007426.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLO based on UniProtKB P27248.
ProteinModelPortal	Q3IN28.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IN28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3702746.
GenomeReviews	Gene locus NP4774A in contig CR936257_GR.
KEGG	nph:NP4774A.
NMPDR	fig|348780.3.peg.2633.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG06551.
HOGENOM	HBG299834.
OMA	DAIANDC.
PhylomeDB	Q3IN28.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	NPHA348780:NP4774A-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_NATPD

Accession

Primary (citable) accession number: Q3IN28

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 8, 2005
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program