Q3IMJ0 (HIS3_NATPD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosyl-AMP cyclohydrolase
Short name=PRA-CH
EC=3.5.4.19

Gene names

Name:	hisI
Ordered Locus Names:	NP5154A

Organism

Natronomonas pharaonis (strain DSM 2160 / ATCC 35678) [Complete proteome] [HAMAP]

Taxonomic identifier

348780 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Natronomonas

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01021
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. HAMAP MF_01021
Subcellular location	Cytoplasm By similarity HAMAP MF_01021.
Sequence similarities	Belongs to the PRA-CH family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoribosyl-AMP cyclohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01021		PRO_0000229847

Sequences

	Sequence		Length	Mass (Da)
	Q3IMJ0 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 046A3955DE5D8BF5	FASTA	120	13,357
	10 20 30 40 50 60 MSVDLAFDEQ ELLPAVAQDA ESGDVLMLAY VSEEAVARSR ETGYAHYYSR SREELWKKGG 70 80 90 100 110 120 SSGHTQEIEE IRVDCDGDAI LYLVEQAGGA CHTGYDTCFH RTLDGDIVGE QVFDPEEIYE

References

[1]

"Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis." Falb M., Pfeiffer F., Palm P., Rodewald K., Hickmann V., Tittor J., Oesterhelt D. Genome Res. 15:1336-1343(2005) [PubMed: 16169924] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 2160 / ATCC 35678.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR936257 Genomic DNA. Translation: CAI50668.1.
RefSeq	YP_331300.1. NC_007426.1.
3D structure databases
ProteinModelPortal	Q3IMJ0.
SMR	Q3IMJ0. Positions 3-115.
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IMJ0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3702822.
GenomeReviews	Gene locus NP5154A in contig CR936257_GR.
KEGG	nph:NP5154A.
NMPDR	fig|348780.3.peg.2037.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG12274.
HOGENOM	HBG294308.
OMA	GACHVGY.
PhylomeDB	Q3IMJ0.
ProtClustDB	PRK00051.
Enzyme and pathway databases
BioCyc	NPHA348780:NP5154A-MONOMER.
Family and domain databases
HAMAP	MF_01021. HisI. [Tree]
InterPro	IPR002496. PRib_AMP_CycHydrolase. [Graphical view]
KO	K01496.
Pfam	PF01502. PRA-CH. 1 hit. [Graphical view]
ProDom	PD002610. PRA_CycHdrlase. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

HIS3_NATPD

Accession

Primary (citable) accession number: Q3IMJ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 8, 2005
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program