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Protein

dCTP deaminase

Gene

dcd

Organism
Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the deamination of dCTP to dUTP.UniRule annotation

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123dCTPUniRule annotation1
Active sitei133Proton donor/acceptorUniRule annotation1
Binding sitei152dCTPUniRule annotation1
Binding sitei166dCTPUniRule annotation1
Binding sitei173dCTPUniRule annotation1
Binding sitei177dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 110dCTP bindingUniRule annotation6
Nucleotide bindingi131 – 133dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciNPHA348780:G1GI2-2565-MONOMER
UniPathwayiUPA00610; UER00665

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:NP_5166A
OrganismiNatronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / NBRC 14720 / NCIMB 2260 / Gabara) (Halobacterium pharaonis)
Taxonomic identifieri348780 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHaloarculaceaeNatronomonas
Proteomesi
  • UP000002698 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000097661 – 195dCTP deaminaseAdd BLAST195

Proteomic databases

PRIDEiQ3IMI4

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi348780.NP5166A

Structurei

3D structure databases

ProteinModelPortaliQ3IMI4
SMRiQ3IMI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04048 Archaea
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiGQLCLFR
OrthoDBiPOG093Z0C6C

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR011962 dCTP_deaminase
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q3IMI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSDADIRR RLDEGDLAIE PLDDPELQVQ PASVDLRLGR EFLEFQRANI
60 70 80 90 100
SCIHPTSERE VDEYVDETYV EEGEEFVLHP GDFVLGTTKE RVEIPPDLIA
110 120 130 140 150
HVEGRSSLGR LAIVVHATAG LCDPGYQGQI TLELSNLGTA PVALSPGMRI
160 170 180 190
SQLTFTELKS PAERPYGAER GSKYQGQTGP QASRIQGDRE FGGDQ
Length:195
Mass (Da):21,446
Last modified:November 8, 2005 - v1
Checksum:iD33EC4A1AEFCDA7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR936257 Genomic DNA Translation: CAI50674.1
RefSeqiWP_011324284.1, NC_007426.1

Genome annotation databases

EnsemblBacteriaiCAI50674; CAI50674; NP_5166A
GeneIDi3702659
KEGGinph:NP_5166A

Similar proteinsi

Entry informationi

Entry nameiDCD_NATPD
AccessioniPrimary (citable) accession number: Q3IMI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health