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Q3ILJ5

- GCH4_PSEHT

UniProt

Q3ILJ5 - GCH4_PSEHT

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 2 (05 May 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei151 – 1511May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-557-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:PSHAa0549
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302GTP cyclohydrolase FolE2PRO_0000289506Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326442.PSHAa0549.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000247517.
    KOiK09007.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3ILJ5-1 [UniParc]FASTAAdd to Basket

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    MPDIANTAPA LQTGTLDWVG MGEIELPFIF ESHGITPVTV NAKARAFVNL    50
    HKEDAKGIHM SRLFLALDTL STEQQVNPQT LAQALDFFIS SHEGLSDKAL 100
    IEFKFELPLR RKSLLSDKAG WKSYPVILTS TIEQGVINYE LSVDVTYSST 150
    CPCSAALARQ LIQNAFAEKF SQETLSQKEA LEWLGTTQGI VATPHSQRSI 200
    ANVKVKLDSN ITQFDVVNLI NTIEDELKTP VQAAVKREDE QEFARLNGQN 250
    LMFCEDAARK IKALLETQQY SDYWLQINHY ESLHAHDALA IAVKGVAGGY 300
    RA 302
    Length:302
    Mass (Da):33,539
    Last modified:May 5, 2009 - v2
    Checksum:iFEDB0E3EC8D88873
    GO

    Sequence cautioni

    The sequence CAI85637.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI85637.1. Different initiation.
    RefSeqiYP_339080.1. NC_007481.1.

    Genome annotation databases

    EnsemblBacteriaiCAI85637; CAI85637; PSHAa0549.
    GeneIDi3708697.
    KEGGipha:PSHAa0549.
    PATRICi32294625. VBIPseHal105694_0518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI85637.1 . Different initiation.
    RefSeqi YP_339080.1. NC_007481.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAa0549.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI85637 ; CAI85637 ; PSHAa0549 .
    GeneIDi 3708697.
    KEGGi pha:PSHAa0549.
    PATRICi 32294625. VBIPseHal105694_0518.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000247517.
    KOi K09007.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci PHAL326442:GJIU-557-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiGCH4_PSEHT
    AccessioniPrimary (citable) accession number: Q3ILJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 5, 2009
    Last modified: October 1, 2014
    This is version 55 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3