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Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei186 – 1861S-adenosyl-L-methionineUniRule annotation
Binding sitei238 – 2381S-adenosyl-L-methionineUniRule annotation
Binding sitei258 – 2581S-adenosyl-L-methionineUniRule annotation
Binding sitei275 – 2751S-adenosyl-L-methionineUniRule annotation
Active sitei304 – 3041Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-1081-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:PSHAa1067
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
Proteomesi
  • UP000006843 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Ribosomal RNA large subunit methyltransferase MPRO_0000070415Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi326442.PSHAa1067.

Structurei

3D structure databases

ProteinModelPortaliQ3IKB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni219 – 2224S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiEOG651SSR.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IKB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVVIYCRS GFENDAAAEI TFHAAEQGFA GYVKAKPNTG YVIYECFDAQ
60 70 80 90 100
HGDEIIKKVD FKNMVFARQW FAGTLIENMP VEDRVGAVVE AAKDFTLCSE
110 120 130 140 150
LRVETPDTNE GKELLTFCKK ISTPLKKALE KRNIVLREPK ANRPVMHVLF
160 170 180 190 200
LTNNTAYVGY SYSFNNSPFF MGILRLRMPS DAPSRSTLKL DEAFNVFIPE
210 220 230 240 250
QQRESRVAAG MRSVDLGACP GGWTYQLVRR GMFVSAIDNG PMNDDLMQTG
260 270 280 290 300
QVKHFRADGF KYRPEKRNIT WLVCDMVEKP TKVTSLMIDW AVNAYAKELI
310 320 330 340 350
FNLKLPMKKR FDSVYECLSM IRAELEKYGI SYELQAKHLY HDREEVTVHL
360
NVTKVPQSLY S
Length:361
Mass (Da):41,191
Last modified:November 8, 2005 - v1
Checksum:i62974E54AF2A6290
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA. Translation: CAI86142.1.
RefSeqiWP_011327753.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI86142; CAI86142; PSHAa1067.
GeneIDi3710128.
KEGGipha:PSHAa1067.
PATRICi32295675. VBIPseHal105694_1024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA. Translation: CAI86142.1.
RefSeqiWP_011327753.1. NC_007481.1.

3D structure databases

ProteinModelPortaliQ3IKB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326442.PSHAa1067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI86142; CAI86142; PSHAa1067.
GeneIDi3710128.
KEGGipha:PSHAa1067.
PATRICi32295675. VBIPseHal105694_1024.

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.
OrthoDBiEOG651SSR.

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-1081-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiRLMM_PSEHT
AccessioniPrimary (citable) accession number: Q3IKB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 8, 2005
Last modified: November 11, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.