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Q3IJ93

- SYL_PSEHT

UniProt

Q3IJ93 - SYL_PSEHT

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Protein
Leucine--tRNA ligase
Gene
leuS, PSHAa1031
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei625 – 6251ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-1038-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PSHAa1031
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligaseUniRule annotation
PRO_1000009400Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAa1031.

Structurei

3D structure databases

ProteinModelPortaliQ3IJ93.
SMRiQ3IJ93. Positions 228-415.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi622 – 6265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q3IJ93-1 [UniParc]FASTAAdd to Basket

« Hide

MQEQYNPQKI ESKIQRYWEE NKVFKVTEDE SKEKYYCLSM FPYPSGRLHM    50
GHVRNYTIGD VVSRFQRLKG KNVMQPMGWD AFGLPAENAA IKNKTAPAKW 100
TYENIDYMRT QLKQLGFGYD WDREIATCHP EYYKWEQWFF TKLYEKGLVY 150
KKMSTVNWDP VDQTVLANEQ VIDGRGWRSG AVVEQKEIPQ WFIKITDYAQ 200
ELLDDLDKLE DWPEQVKTMQ RNWIGRSEGC DIEFKRTDNN ETFSVYTTRP 250
DTFMGVTYVA VAAGHPIAKE AAKNSDSVAL FVEECKNNKV SEADMATMEK 300
KGIATGFFAT HPLTGEQVPI WIANFVLMHY GSGAVMAVPA HDQRDFEFAT 350
AYGLDIKQVI APVTGSDLEV NLNKEAFTDK GVLVNSGEFD GLDFDAAFNA 400
IADKLEALGV GERKVNFRLR DWGVSRQRYW GSPIPMLSDE DGNELAATDD 450
MLPVRLPEDV VMNGVTSPIK ADPNWAKTTM NGAPAFHETD TFDTFMESSW 500
YYARYCSPRH DEGMLDPAAA NYWLPVNQYI GGIEHAILHL LYSRFFHKLL 550
RDFGLVDSDE PFDRLLCQGM VLAETFYRKD EKGADIWISP SDVNTETDDK 600
GRVTKAWHKV DGNPVFSSGM SKMSKSKNNG IDPQHVIAQY GADTVRLFMM 650
FTAPPEQTLE WSDAGVEGAH RFLKRVWKYA VDVKTVGFQP LNKTALNNEQ 700
KVLRRDLHKA IAKVSDDVER RQTFNTAIAA IMELSNKLLK APLNSKQDVA 750
IANEALEAML IMLAPITPHL SHQLWQELGK EGDIVNASWP EVDQSALVED 800
EKLIIIQVNG KLRAKLTVAA DATKEQVEAL AFEQASVTKY TDGVTVRKVI 850
YVPGKLLNVV AN 862
Length:862
Mass (Da):97,721
Last modified:November 8, 2005 - v1
Checksum:i323B8C27F25615BB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI86109.1.
RefSeqiWP_011327720.1. NC_007481.1.
YP_339552.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI86109; CAI86109; PSHAa1031.
GeneIDi3710242.
KEGGipha:PSHAa1031.
PATRICi32295589. VBIPseHal105694_0991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI86109.1 .
RefSeqi WP_011327720.1. NC_007481.1.
YP_339552.1. NC_007481.1.

3D structure databases

ProteinModelPortali Q3IJ93.
SMRi Q3IJ93. Positions 228-415.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAa1031.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI86109 ; CAI86109 ; PSHAa1031 .
GeneIDi 3710242.
KEGGi pha:PSHAa1031.
PATRICi 32295589. VBIPseHal105694_0991.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PHAL326442:GJIU-1038-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiSYL_PSEHT
AccessioniPrimary (citable) accession number: Q3IJ93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi