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Q3IJ93

- SYL_PSEHT

UniProt

Q3IJ93 - SYL_PSEHT

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei625 – 6251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-1038-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PSHAa1031
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Leucine--tRNA ligasePRO_1000009400Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326442.PSHAa1031.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IJ93.
    SMRiQ3IJ93. Positions 228-415.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi622 – 6265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q3IJ93-1 [UniParc]FASTAAdd to Basket

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    MQEQYNPQKI ESKIQRYWEE NKVFKVTEDE SKEKYYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVSRFQRLKG KNVMQPMGWD AFGLPAENAA IKNKTAPAKW 100
    TYENIDYMRT QLKQLGFGYD WDREIATCHP EYYKWEQWFF TKLYEKGLVY 150
    KKMSTVNWDP VDQTVLANEQ VIDGRGWRSG AVVEQKEIPQ WFIKITDYAQ 200
    ELLDDLDKLE DWPEQVKTMQ RNWIGRSEGC DIEFKRTDNN ETFSVYTTRP 250
    DTFMGVTYVA VAAGHPIAKE AAKNSDSVAL FVEECKNNKV SEADMATMEK 300
    KGIATGFFAT HPLTGEQVPI WIANFVLMHY GSGAVMAVPA HDQRDFEFAT 350
    AYGLDIKQVI APVTGSDLEV NLNKEAFTDK GVLVNSGEFD GLDFDAAFNA 400
    IADKLEALGV GERKVNFRLR DWGVSRQRYW GSPIPMLSDE DGNELAATDD 450
    MLPVRLPEDV VMNGVTSPIK ADPNWAKTTM NGAPAFHETD TFDTFMESSW 500
    YYARYCSPRH DEGMLDPAAA NYWLPVNQYI GGIEHAILHL LYSRFFHKLL 550
    RDFGLVDSDE PFDRLLCQGM VLAETFYRKD EKGADIWISP SDVNTETDDK 600
    GRVTKAWHKV DGNPVFSSGM SKMSKSKNNG IDPQHVIAQY GADTVRLFMM 650
    FTAPPEQTLE WSDAGVEGAH RFLKRVWKYA VDVKTVGFQP LNKTALNNEQ 700
    KVLRRDLHKA IAKVSDDVER RQTFNTAIAA IMELSNKLLK APLNSKQDVA 750
    IANEALEAML IMLAPITPHL SHQLWQELGK EGDIVNASWP EVDQSALVED 800
    EKLIIIQVNG KLRAKLTVAA DATKEQVEAL AFEQASVTKY TDGVTVRKVI 850
    YVPGKLLNVV AN 862
    Length:862
    Mass (Da):97,721
    Last modified:November 8, 2005 - v1
    Checksum:i323B8C27F25615BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI86109.1.
    RefSeqiWP_011327720.1. NC_007481.1.
    YP_339552.1. NC_007481.1.

    Genome annotation databases

    EnsemblBacteriaiCAI86109; CAI86109; PSHAa1031.
    GeneIDi3710242.
    KEGGipha:PSHAa1031.
    PATRICi32295589. VBIPseHal105694_0991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI86109.1 .
    RefSeqi WP_011327720.1. NC_007481.1.
    YP_339552.1. NC_007481.1.

    3D structure databases

    ProteinModelPortali Q3IJ93.
    SMRi Q3IJ93. Positions 228-415.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAa1031.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI86109 ; CAI86109 ; PSHAa1031 .
    GeneIDi 3710242.
    KEGGi pha:PSHAa1031.
    PATRICi 32295589. VBIPseHal105694_0991.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PHAL326442:GJIU-1038-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiSYL_PSEHT
    AccessioniPrimary (citable) accession number: Q3IJ93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3