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Q3IIW8

- LPXB_PSEHT

UniProt

Q3IIW8 - LPXB_PSEHT

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-2069-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:PSHAa2017
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 385385Lipid-A-disaccharide synthasePRO_0000255206Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326442.PSHAa2017.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IIW8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3IIW8-1 [UniParc]FASTAAdd to Basket

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    MNKDQKQLRI GIVAGELSGD ILGEGLIKAL KKHFPDAIFE GIAGPKMQAQ    50
    GCNTLYDMDE LSVMGLVEVL GRLPRLLKIR KQLVQHFIDN PPDVFIGIDA 100
    PDFNLRVEKP LKDAGIKTVQ YVSPSVWAWR EKRIHTISAA TNLVLALLPF 150
    EKEFYDKHQV PCTFVGHTLA DDIALEHDDS KARKELGLSP DDKVLALLPG 200
    SRGSEVGLLS ETYIKTAVQL QAQNPALKIV VPLVNAKRKA QFTEILNATA 250
    PTLKISLLDG QSKQAMQAAD AILLASGTAT LEGMLYKKPM VVGYKIKPLS 300
    YWIFKTLFTF NIKYFSLPNL LADEELVPEF LQSECNVANL TQALTPMLNT 350
    DNQALKARFL AIHKKIRLNA SEQAANAVAE LINAN 385
    Length:385
    Mass (Da):42,491
    Last modified:November 8, 2005 - v1
    Checksum:i5EB17FDA1F34F8B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87073.1.
    RefSeqiWP_011328675.1. NC_007481.1.
    YP_340516.1. NC_007481.1.

    Genome annotation databases

    EnsemblBacteriaiCAI87073; CAI87073; PSHAa2017.
    GeneIDi3710256.
    KEGGipha:PSHAa2017.
    PATRICi32297631. VBIPseHal105694_1944.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87073.1 .
    RefSeqi WP_011328675.1. NC_007481.1.
    YP_340516.1. NC_007481.1.

    3D structure databases

    ProteinModelPortali Q3IIW8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAa2017.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI87073 ; CAI87073 ; PSHAa2017 .
    GeneIDi 3710256.
    KEGGi pha:PSHAa2017.
    PATRICi 32297631. VBIPseHal105694_1944.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PHAL326442:GJIU-2069-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiLPXB_PSEHT
    AccessioniPrimary (citable) accession number: Q3IIW8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3