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Q3IIC3

- PUR9_PSEHT

UniProt

Q3IIC3 - PUR9_PSEHT

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-350-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:PSHAa0345
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 528528Bifunctional purine biosynthesis protein PurHPRO_1000018939Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326442.PSHAa0345.

Structurei

3D structure databases

ProteinModelPortaliQ3IIC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IIC3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTHRPIRRA LLSVSDKTGI VEFARALEAQ GVDILSTGGT CKLLADNGIK
60 70 80 90 100
VTEVSDHTGH PEIMDGRVKT LHPKIHGGIL ARRGQDESVM AENNISAIDI
110 120 130 140 150
VVVNLYPFAN TVAQENCSLE DAIENIDIGG PTMVRAAAKN HKDVTIVVNA
160 170 180 190 200
SDYDRVISEM QSNKGSTTYK TRFDLAIAAY EHTAQYDGMI ANYFGKMVPD
210 220 230 240 250
YTEEAAEDTK FPRTINMQFT KKQDMRYGEN SHQDAAFYVE NDIVEASVAT
260 270 280 290 300
ATQLQGKALS FNNIADTDAA LECVKEFDVP ACVIVKHANP CGVSIGSNIL
310 320 330 340 350
EAYERAFKTD PTSAFGGIIA FNQELDAATA EAIVERQFVE VIIAPSVSDA
360 370 380 390 400
AAKIVSAKQN VRLLVCGQWT DKAAGQDIKR VNGGILVQDR DLGMVTQGDL
410 420 430 440 450
KVVSKRQPTE QELKDLLFCW KVAKFVKSNA IVYARDGMTI GVGAGQMSRV
460 470 480 490 500
YSAKIAGIKA ADENLEVKGS VMASDAFFPF RDGIDAAAAA GITAVIQPGG
510 520
SMRDAEVIAA ADEAGMAMVL TGMRHFRH
Length:528
Mass (Da):56,965
Last modified:November 8, 2005 - v1
Checksum:i21997ADC1AD995BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA. Translation: CAI85443.1.
RefSeqiWP_011327057.1. NC_007481.1.
YP_338886.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI85443; CAI85443; PSHAa0345.
GeneIDi3709937.
KEGGipha:PSHAa0345.
PATRICi32294221. VBIPseHal105694_0328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA. Translation: CAI85443.1 .
RefSeqi WP_011327057.1. NC_007481.1.
YP_338886.1. NC_007481.1.

3D structure databases

ProteinModelPortali Q3IIC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAa0345.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI85443 ; CAI85443 ; PSHAa0345 .
GeneIDi 3709937.
KEGGi pha:PSHAa0345.
PATRICi 32294221. VBIPseHal105694_0328.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PHAL326442:GJIU-350-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiPUR9_PSEHT
AccessioniPrimary (citable) accession number: Q3IIC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3