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Q3IHV1

- UPPP1_PSEHT

UniProt

Q3IHV1 - UPPP1_PSEHT

Protein

Undecaprenyl-diphosphatase 1

Gene

uppP1

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-2357-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 1UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 1UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 1UniRule annotation
    Gene namesi
    Name:uppP1UniRule annotation
    Ordered Locus Names:PSHAa2300
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 266266Undecaprenyl-diphosphatase 1PRO_0000227627Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326442.PSHAa2300.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5921HelicalUniRule annotationAdd
    BLAST
    Transmembranei83 – 10321HelicalUniRule annotationAdd
    BLAST
    Transmembranei113 – 13321HelicalUniRule annotationAdd
    BLAST
    Transmembranei141 – 16121HelicalUniRule annotationAdd
    BLAST
    Transmembranei189 – 20921HelicalUniRule annotationAdd
    BLAST
    Transmembranei218 – 23821HelicalUniRule annotationAdd
    BLAST
    Transmembranei244 – 26421HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiIEGPFRD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3IHV1-1 [UniParc]FASTAAdd to Basket

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    MSIIEIIVLA LIQGFTEFLP ISSSAHLILP SQILGWEDQG LAFDVAVHVG    50
    TLIAVVIYFR KEVSSILSAW FKSFGAQGST DDSKLGWWII LGTIPAAILG 100
    LLLKDMIELY LRSAWVIAVT TIIFGLLLWY ADAKGKQIKT IYQLNWKTAL 150
    IIGLAQAVAM IPGTSRSGIT MTAGLMLGMN KQSAARFSFL LAIPIISMMG 200
    LYYTVELALG DHLVDWSTLL LGVVLSFLSA YVCIYMFLKV IERMGMLPFV 250
    IYRLLLGVGL IVFLTL 266
    Length:266
    Mass (Da):29,257
    Last modified:November 8, 2005 - v1
    Checksum:i3CAC9DA3594F90C3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87356.1.
    RefSeqiYP_340798.1. NC_007481.1.

    Genome annotation databases

    EnsemblBacteriaiCAI87356; CAI87356; PSHAa2300.
    GeneIDi3708342.
    KEGGipha:PSHAa2300.
    PATRICi32298193. VBIPseHal105694_2220.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87356.1 .
    RefSeqi YP_340798.1. NC_007481.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAa2300.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI87356 ; CAI87356 ; PSHAa2300 .
    GeneIDi 3708342.
    KEGGi pha:PSHAa2300.
    PATRICi 32298193. VBIPseHal105694_2220.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi IEGPFRD.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci PHAL326442:GJIU-2357-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiUPPP1_PSEHT
    AccessioniPrimary (citable) accession number: Q3IHV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 21, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3