Q3IHV1 (UPPP1_PSEHT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 1
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1

Gene names

Name:	uppP1
Ordered Locus Names:	PSHAa2300

Organism

Pseudoalteromonas haloplanktis (strain TAC 125) [Complete proteome] [HAMAP]

Taxonomic identifier

326442 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Pseudoalteromonadaceae › Pseudoalteromonas

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 266	266	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000227627
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	141 – 161	21	Helical; Potential
	Transmembrane	189 – 209	21	Helical; Potential
	Transmembrane	218 – 238	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q3IHV1 [UniParc]. Last modified November 8, 2005. Version 1. Checksum: 3CAC9DA3594F90C3	FASTA	266	29,257
	10 20 30 40 50 60 MSIIEIIVLA LIQGFTEFLP ISSSAHLILP SQILGWEDQG LAFDVAVHVG TLIAVVIYFR 70 80 90 100 110 120 KEVSSILSAW FKSFGAQGST DDSKLGWWII LGTIPAAILG LLLKDMIELY LRSAWVIAVT 130 140 150 160 170 180 TIIFGLLLWY ADAKGKQIKT IYQLNWKTAL IIGLAQAVAM IPGTSRSGIT MTAGLMLGMN 190 200 210 220 230 240 KQSAARFSFL LAIPIISMMG LYYTVELALG DHLVDWSTLL LGVVLSFLSA YVCIYMFLKV 250 260 IERMGMLPFV IYRLLLGVGL IVFLTL

References

[1]

"Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125." Medigue C., Krin E., Pascal G., Barbe V., Bernsel A., Bertin P.N., Cheung F., Cruveiller S., D'Amico S., Duilio A., Fang G., Feller G., Ho C., Mangenot S., Marino G., Nilsson J., Parrilli E., Rocha E.P.C. , Rouy Z., Sekowska A., Tutino M.L., Vallenet D., von Heijne G., Danchin A. Genome Res. 15:1325-1335(2005) [PubMed: 16169927] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TAC 125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR954246 Genomic DNA. Translation: CAI87356.1.
RefSeq	YP_340798.1. NC_007481.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q3IHV1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3708342.
GenomeReviews	Gene locus PSHAa2300 in contig CR954246_GR.
KEGG	pha:PSHAa2300.
NMPDR	fig|326442.4.peg.2313.
PATRIC	32298193. VBIPseHal105694_2220.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HBG391969.
OMA	ITITTAR.
PhylomeDB	Q3IHV1.
ProtClustDB	PRK00281.
Enzyme and pathway databases
BioCyc	PHAL326442:PSHAA2300-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. Undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP1_PSEHT

Accession

Primary (citable) accession number: Q3IHV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	November 8, 2005
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program