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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi372 – 379ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:PSHAa1661
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
Proteomesi
  • UP000006843 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalUniRule annotationAdd BLAST21
Transmembranei65 – 85HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei161 – 181HelicalUniRule annotationAdd BLAST21
Transmembranei246 – 266HelicalUniRule annotationAdd BLAST21
Transmembranei271 – 291HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716391 – 581Lipid A export ATP-binding/permease protein MsbAAdd BLAST581

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi326442.PSHAa1661.

Structurei

3D structure databases

ProteinModelPortaliQ3IGX5.
SMRiQ3IGX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 306ABC transmembrane type-1UniRule annotationAdd BLAST284
Domaini338 – 575ABC transporterUniRule annotationAdd BLAST238

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.
OrthoDBiPOG091H00DB.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IGX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQSTTQIYK RLISYVGAYR TVAIVAIIGM IGYSGMDALF IQLMKPFIDE
60 70 80 90 100
GLNERNADVL KYAPFVVIAL VIGRGVFNFM SSYCLSYVGS QVVRSLRQEL
110 120 130 140 150
FEHILHLPVS FHDKNSTGDL ISKITFDTEQ VQQAITKALL IVVREGAFVV
160 170 180 190 200
FLLAVMFYTS WQLSLIFLVI IPLVAVIVTV VSKRFRHISK SIQSAMGQVT
210 220 230 240 250
RSSEQMLSGH KVIHGFGGQN QEIDQFSKVN NHNRQQRIKM DATKALSVSI
260 270 280 290 300
IQVLAASAMA VILWVVSMPS MIDTISSGDF VVLISSMMML LRPLKQLANV
310 320 330 340 350
NSDMQRGVSA AQSVFLILDE EVEKDTGTVS VDKVKGLIEV KNVTFKYPTK
360 370 380 390 400
DEPVLNNLSL TIKAGESIAL VGRSGSGKST ISNLLPRYYD LEAPSEILLD
410 420 430 440 450
GIALHDYKLT DLRRQFALVS QQVVLFNDSI ANNICYGLQR EISQQELEKV
460 470 480 490 500
AKQAHVWEFV KDLPEQLNTM VGENGVMLSG GQRQRIAIAR AILKDAPILI
510 520 530 540 550
LDEATSALDT ESEKLIQQAL EALMKDKTSI VIAHRLSTIE NSDRIYVIDN
560 570 580
GSVIESGDHL SLLANNGTYS ALCKMQFGEQ G
Length:581
Mass (Da):64,303
Last modified:November 8, 2005 - v1
Checksum:iAC8A498C4AF40B10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA. Translation: CAI86734.1.
RefSeqiWP_011328339.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI86734; CAI86734; PSHAa1661.
KEGGipha:PSHAa1661.
PATRICifig|326442.8.peg.1606.

Similar proteinsi

Entry informationi

Entry nameiMSBA_PSEHT
AccessioniPrimary (citable) accession number: Q3IGX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 8, 2005
Last modified: June 7, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families