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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-2528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PSHAa2473
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Glycine dehydrogenase (decarboxylating)PRO_0000227115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei710 – 7101N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi326442.PSHAa2473.

Structurei

3D structure databases

ProteinModelPortaliQ3IFW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR018247. EF_Hand_1_Ca_BS.
IPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IFW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNAKSLEQL EQTQDFIRRH IGPSPAQVSD MLSALEVSSV EELIGQTVPA
60 70 80 90 100
GIRLEQPLTV GESRTEVETL SYLKSVASKN KVFKSYIGQG YHPTHVPHVI
110 120 130 140 150
LRNVLENPGW YTAYTPYQPE IAQGRLESLL NFQTMTLDLT GLDLASASLL
160 170 180 190 200
DESTAAAEAM GLAKRVSKAK KANAFFIADD VHTQTIDVVS TRAEQFGFEI
210 220 230 240 250
IVGKAADAVN HEIFGALFQY PSTTGEVVDI TDLIAGVQSK KAIACVAADI
260 270 280 290 300
MSLLLLKAPG KLGADVVLGS AQRFGVPMGY GGPHAAFFAT RDAYKRSLPG
310 320 330 340 350
RIIGVSKDRL GNDALRMAMQ TREQHIRRDK ANSNICTAQV LLANMAAFYA
360 370 380 390 400
VYHGPQGLKT IAQRIHRFAD ILAAGLQAKG VSLKHNTWFD TLTVVSDSKA
410 420 430 440 450
DVIARALASG VNFATNRDGE YSIALSETTT RADVAQLFDI VLGEGHGLSV
460 470 480 490 500
DAIAADIENN GSTSIPASLE RDDEVLTHPN FNSYHSETEM LRYIKRLENK
510 520 530 540 550
DLALNHSMIS LGSCTMKLNA TAEMIPITWP EFSNLHPFCP LDQAQGYQIM
560 570 580 590 600
MGELHDWLVN ITGYDAVSLQ PNSGAQGEYA GLIAIRKYHE SRGDAHRNVC
610 620 630 640 650
LIPSSAHGTN PASAQMASMK IVVVDCDKNG NVDMADLKAK AEAVAENLSC
660 670 680 690 700
IMITYPSTHG VYEETIREIC DVIHQHGGQV YMDGANMNAQ VGVTSPGFIG
710 720 730 740 750
SDVSHLNLHK TFCIPHGGGG PGVGPIGVKS HLAPFMPNHS IINVPGTNEG
760 770 780 790 800
NGAVSAAPYG SASILPISWA YITMMGSEGL KQATEMAIVN ANYLTHELSK
810 820 830 840 850
HFPILYRGRN NRVAHECIVD LRPLKELSGI TEMDVAKRLQ DYGFHSPTMS
860 870 880 890 900
FPVAGTLMIE PTESESKVEI DRFIEAMVSI KSEIDKVISG EWSIENNPLV
910 920 930 940 950
FAPHTQGDVL GNEWDRAYDR FYAAFPVPSV AKNKFWPTVT RIDDVYGDRN
960
LVCACPPVET YRD
Length:963
Mass (Da):104,691
Last modified:November 8, 2005 - v1
Checksum:iC732B6F522FF4035
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA. Translation: CAI87521.1.
RefSeqiWP_011329121.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI87521; CAI87521; PSHAa2473.
GeneIDi3708095.
KEGGipha:PSHAa2473.
PATRICi32298531. VBIPseHal105694_2383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR954246 Genomic DNA. Translation: CAI87521.1.
RefSeqiWP_011329121.1. NC_007481.1.

3D structure databases

ProteinModelPortaliQ3IFW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326442.PSHAa2473.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI87521; CAI87521; PSHAa2473.
GeneIDi3708095.
KEGGipha:PSHAa2473.
PATRICi32298531. VBIPseHal105694_2383.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-2528-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR018247. EF_Hand_1_Ca_BS.
IPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiGCSP_PSEHT
AccessioniPrimary (citable) accession number: Q3IFW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.