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Q3IFW1

- GCSP_PSEHT

UniProt

Q3IFW1 - GCSP_PSEHT

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPHAL326442:GJIU-2528-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PSHAa2473
    OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
    Taxonomic identifieri326442 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
    ProteomesiUP000006843: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 963963Glycine dehydrogenase (decarboxylating)PRO_0000227115Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei710 – 7101N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi326442.PSHAa2473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ3IFW1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR018247. EF_Hand_1_Ca_BS.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q3IFW1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNAKSLEQL EQTQDFIRRH IGPSPAQVSD MLSALEVSSV EELIGQTVPA    50
    GIRLEQPLTV GESRTEVETL SYLKSVASKN KVFKSYIGQG YHPTHVPHVI 100
    LRNVLENPGW YTAYTPYQPE IAQGRLESLL NFQTMTLDLT GLDLASASLL 150
    DESTAAAEAM GLAKRVSKAK KANAFFIADD VHTQTIDVVS TRAEQFGFEI 200
    IVGKAADAVN HEIFGALFQY PSTTGEVVDI TDLIAGVQSK KAIACVAADI 250
    MSLLLLKAPG KLGADVVLGS AQRFGVPMGY GGPHAAFFAT RDAYKRSLPG 300
    RIIGVSKDRL GNDALRMAMQ TREQHIRRDK ANSNICTAQV LLANMAAFYA 350
    VYHGPQGLKT IAQRIHRFAD ILAAGLQAKG VSLKHNTWFD TLTVVSDSKA 400
    DVIARALASG VNFATNRDGE YSIALSETTT RADVAQLFDI VLGEGHGLSV 450
    DAIAADIENN GSTSIPASLE RDDEVLTHPN FNSYHSETEM LRYIKRLENK 500
    DLALNHSMIS LGSCTMKLNA TAEMIPITWP EFSNLHPFCP LDQAQGYQIM 550
    MGELHDWLVN ITGYDAVSLQ PNSGAQGEYA GLIAIRKYHE SRGDAHRNVC 600
    LIPSSAHGTN PASAQMASMK IVVVDCDKNG NVDMADLKAK AEAVAENLSC 650
    IMITYPSTHG VYEETIREIC DVIHQHGGQV YMDGANMNAQ VGVTSPGFIG 700
    SDVSHLNLHK TFCIPHGGGG PGVGPIGVKS HLAPFMPNHS IINVPGTNEG 750
    NGAVSAAPYG SASILPISWA YITMMGSEGL KQATEMAIVN ANYLTHELSK 800
    HFPILYRGRN NRVAHECIVD LRPLKELSGI TEMDVAKRLQ DYGFHSPTMS 850
    FPVAGTLMIE PTESESKVEI DRFIEAMVSI KSEIDKVISG EWSIENNPLV 900
    FAPHTQGDVL GNEWDRAYDR FYAAFPVPSV AKNKFWPTVT RIDDVYGDRN 950
    LVCACPPVET YRD 963
    Length:963
    Mass (Da):104,691
    Last modified:November 8, 2005 - v1
    Checksum:iC732B6F522FF4035
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87521.1.
    RefSeqiYP_340963.1. NC_007481.1.

    Genome annotation databases

    EnsemblBacteriaiCAI87521; CAI87521; PSHAa2473.
    GeneIDi3708095.
    KEGGipha:PSHAa2473.
    PATRICi32298531. VBIPseHal105694_2383.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR954246 Genomic DNA. Translation: CAI87521.1 .
    RefSeqi YP_340963.1. NC_007481.1.

    3D structure databases

    ProteinModelPortali Q3IFW1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326442.PSHAa2473.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI87521 ; CAI87521 ; PSHAa2473 .
    GeneIDi 3708095.
    KEGGi pha:PSHAa2473.
    PATRICi 32298531. VBIPseHal105694_2383.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PHAL326442:GJIU-2528-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR018247. EF_Hand_1_Ca_BS.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TAC 125.

    Entry informationi

    Entry nameiGCSP_PSEHT
    AccessioniPrimary (citable) accession number: Q3IFW1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3