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Q3IFW1

- GCSP_PSEHT

UniProt

Q3IFW1 - GCSP_PSEHT

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, PSHAa2473
Organism
Pseudoalteromonas haloplanktis (strain TAC 125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPHAL326442:GJIU-2528-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PSHAa2473
OrganismiPseudoalteromonas haloplanktis (strain TAC 125)
Taxonomic identifieri326442 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesPseudoalteromonadaceaePseudoalteromonas
ProteomesiUP000006843: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 963963Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000227115Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei710 – 7101N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi326442.PSHAa2473.

Structurei

3D structure databases

ProteinModelPortaliQ3IFW1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR018247. EF_Hand_1_Ca_BS.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q3IFW1-1 [UniParc]FASTAAdd to Basket

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MSNAKSLEQL EQTQDFIRRH IGPSPAQVSD MLSALEVSSV EELIGQTVPA    50
GIRLEQPLTV GESRTEVETL SYLKSVASKN KVFKSYIGQG YHPTHVPHVI 100
LRNVLENPGW YTAYTPYQPE IAQGRLESLL NFQTMTLDLT GLDLASASLL 150
DESTAAAEAM GLAKRVSKAK KANAFFIADD VHTQTIDVVS TRAEQFGFEI 200
IVGKAADAVN HEIFGALFQY PSTTGEVVDI TDLIAGVQSK KAIACVAADI 250
MSLLLLKAPG KLGADVVLGS AQRFGVPMGY GGPHAAFFAT RDAYKRSLPG 300
RIIGVSKDRL GNDALRMAMQ TREQHIRRDK ANSNICTAQV LLANMAAFYA 350
VYHGPQGLKT IAQRIHRFAD ILAAGLQAKG VSLKHNTWFD TLTVVSDSKA 400
DVIARALASG VNFATNRDGE YSIALSETTT RADVAQLFDI VLGEGHGLSV 450
DAIAADIENN GSTSIPASLE RDDEVLTHPN FNSYHSETEM LRYIKRLENK 500
DLALNHSMIS LGSCTMKLNA TAEMIPITWP EFSNLHPFCP LDQAQGYQIM 550
MGELHDWLVN ITGYDAVSLQ PNSGAQGEYA GLIAIRKYHE SRGDAHRNVC 600
LIPSSAHGTN PASAQMASMK IVVVDCDKNG NVDMADLKAK AEAVAENLSC 650
IMITYPSTHG VYEETIREIC DVIHQHGGQV YMDGANMNAQ VGVTSPGFIG 700
SDVSHLNLHK TFCIPHGGGG PGVGPIGVKS HLAPFMPNHS IINVPGTNEG 750
NGAVSAAPYG SASILPISWA YITMMGSEGL KQATEMAIVN ANYLTHELSK 800
HFPILYRGRN NRVAHECIVD LRPLKELSGI TEMDVAKRLQ DYGFHSPTMS 850
FPVAGTLMIE PTESESKVEI DRFIEAMVSI KSEIDKVISG EWSIENNPLV 900
FAPHTQGDVL GNEWDRAYDR FYAAFPVPSV AKNKFWPTVT RIDDVYGDRN 950
LVCACPPVET YRD 963
Length:963
Mass (Da):104,691
Last modified:November 8, 2005 - v1
Checksum:iC732B6F522FF4035
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI87521.1.
RefSeqiYP_340963.1. NC_007481.1.

Genome annotation databases

EnsemblBacteriaiCAI87521; CAI87521; PSHAa2473.
GeneIDi3708095.
KEGGipha:PSHAa2473.
PATRICi32298531. VBIPseHal105694_2383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR954246 Genomic DNA. Translation: CAI87521.1 .
RefSeqi YP_340963.1. NC_007481.1.

3D structure databases

ProteinModelPortali Q3IFW1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326442.PSHAa2473.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI87521 ; CAI87521 ; PSHAa2473 .
GeneIDi 3708095.
KEGGi pha:PSHAa2473.
PATRICi 32298531. VBIPseHal105694_2383.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PHAL326442:GJIU-2528-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR018247. EF_Hand_1_Ca_BS.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TAC 125.

Entry informationi

Entry nameiGCSP_PSEHT
AccessioniPrimary (citable) accession number: Q3IFW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 8, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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